Proteins 2
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Questions and Answers

What are the three major steps involved in post-transcriptional modification of RNA?

  • Addition of a 3' cap, splicing, removal of exons
  • Addition of a 5' cap, splicing, removal of exons (correct)
  • Addition of a 3' cap, removal of introns, joining of exons
  • Addition of a 5' cap, removal of introns, splicing

Which bases pair together in DNA according to the text?

  • Guanine - Adenine
  • Adenine - Thymine (correct)
  • Cytosine - Thymine
  • Adenine - Cytosine

What does the universal characteristic of the genetic code imply according to the text?

  • It varies across different species
  • It is conserved from early evolution stages (correct)
  • It has different triplet coding based on the organism
  • It is only conserved in mammals

What is the main function of a messenger RNA (mRNA)?

<p>Protein synthesis (B)</p> Signup and view all the answers

Which nucleotides pair together in RNA according to the text?

<p>Adenine - Uracil (D)</p> Signup and view all the answers

What is the term for the process that removes non-coding sequences from pre-mRNA in post-transcriptional modification?

<p>Splicing (C)</p> Signup and view all the answers

What is the main role of cytosolic ribosomes in protein synthesis?

<p>Synthesizing proteins for the nucleus, mitochondria, or peroxisomes (D)</p> Signup and view all the answers

Which organelle is responsible for synthesizing proteins that are to be exported from the cell or placed in cell membranes?

<p>Endoplasmic reticulum (ER) (B)</p> Signup and view all the answers

What is the main function of the Golgi apparatus in protein synthesis?

<p>Protein phosphorylation (C)</p> Signup and view all the answers

Which post-translational modification can affect protein stability and protein-protein interactions?

<p>Hydroxylation (C)</p> Signup and view all the answers

What is the role of O-glycosylation in the Golgi apparatus during protein synthesis?

<p>Repacking proteins for delivery (A)</p> Signup and view all the answers

Which organelle is associated with synthesizing proteins that are to be exported out of the cell?

<p>Endoplasmic reticulum (ER) (D)</p> Signup and view all the answers

What is the function of targeting signals in protein synthesis?

<p>Help transport proteins to their correct destinations (A)</p> Signup and view all the answers

Which protein synthesis mutation results in a change of the amino acid coded by a specific codon?

<p>Missense mutation (A)</p> Signup and view all the answers

What is the main cause of sickle cell anemia in humans?

<p>Single nucleotide substitution (C)</p> Signup and view all the answers

In which population does sickle cell anemia occur more frequently?

<p>African American (A)</p> Signup and view all the answers

What are the characteristic symptoms of sickle cell anemia?

<p>Episodes of pain, chronic hemolytic anemia, &amp; infections (A)</p> Signup and view all the answers

What is the consequence of a nonsense mutation in protein synthesis?

<p>Termination of translation prematurely (A)</p> Signup and view all the answers

What is the role of GTP in protein synthesis?

<p>Aids in the movement of the ribosome along the mRNA (A)</p> Signup and view all the answers

Which site of the ribosome is responsible for binding an incoming Aminoacyl-tRNA according to the codon?

<p>A site (A)</p> Signup and view all the answers

What happens in Step 2 of protein synthesis?

<p>Generation of the peptide bond in P-site (D)</p> Signup and view all the answers

What is needed for each peptide bond to guarantee translation during protein synthesis?

<p>High-energy phosphate equivalents from GTP (C)</p> Signup and view all the answers

Which type of codons moves into the ribosome A site during termination in protein synthesis?

<p>Stop codons (C)</p> Signup and view all the answers

What is the process by which proteins are transported to appropriate destinations?

<p>Protein Sorting (A)</p> Signup and view all the answers

Which type of modification involves adding a lipid to proteins to increase their binding affinity to biological membranes?

<p>Protein Lipidation (A)</p> Signup and view all the answers

What post-translational modification involves adding a glycan group to proteins?

<p>Glycosylation (B)</p> Signup and view all the answers

Which modification is responsible for the activation of trypsinogen into trypsin?

<p>Acetylation (D)</p> Signup and view all the answers

What can errors in protein sorting lead to?

<p>Disease (B)</p> Signup and view all the answers

Which post-translational modification involves the addition of a methyl group to proteins?

<p>Methylation (D)</p> Signup and view all the answers

What is the main function of the A-site of the ribosome during protein synthesis?

<p>Binding of the aminoacyl-tRNA according to the codon (A)</p> Signup and view all the answers

What is the primary role of GTP in protein synthesis?

<p>Providing high-energy phosphate equivalents for each peptide bond (D)</p> Signup and view all the answers

During protein synthesis, what happens in the E-site of the ribosome?

<p>Occupation by empty tRNA about to exit the ribosome (B)</p> Signup and view all the answers

What is the purpose of post-translational modifications in protein synthesis?

<p>To fold polypeptides into active 3-dimensional forms (C)</p> Signup and view all the answers

In protein biosynthesis, what role do aminoacyl-tRNA synthetases play?

<p>Activating amino acids for tRNA binding (B)</p> Signup and view all the answers

What are the consequences of STOP codons moving into the ribosomal A-site during protein synthesis termination?

<p>Requiring high-energy phosphate equivalents for translation (D)</p> Signup and view all the answers

Where does the addition of a 3 poly-adenylation tail occur in eukaryote genomes?

<p>In the nucleus (C)</p> Signup and view all the answers

Which component recognizes specific signal sequences in mRNA for regulating gene expression?

<p>snRNP (D)</p> Signup and view all the answers

What is the main role of a 5 cap on mRNA molecules?

<p>Preventing mRNA degradation (A)</p> Signup and view all the answers

During protein biosynthesis, which step involves the addition of amino acids to the carboxyl end of the growing peptide chain?

<p>Elongation (B)</p> Signup and view all the answers

What is the function of aminoacyl-tRNA synthetases in protein biosynthesis?

<p>Activate tRNA with specific amino acids (B)</p> Signup and view all the answers

What type of mutation involves the deletion or insertion of 1 or 2 nucleotides in a codon?

<p>Frame-shift mutations (C)</p> Signup and view all the answers

Which type of mutation involves the removal of 'introns' from pre-mRNA?

<p>Splice site mutations (C)</p> Signup and view all the answers

What is the consequence of errors during DNA replication, such as those occurring during meiosis?

<p>Protein and protein synthesis (D)</p> Signup and view all the answers

Which factor is responsible for causing damage to DNA, leading to spontaneous mutations?

<p>Carcinogens &amp; other toxins (B)</p> Signup and view all the answers

What specific amino acid change occurs in the β-globin protein due to a mutation (E22V)?

<p>Glutamic acid to valine (C)</p> Signup and view all the answers

What type of mutation occurs when the codon containing the changed base may code for a different amino acid?

<p>Missense mutation (B)</p> Signup and view all the answers

What is the main function of the Golgi apparatus in relation to protein synthesis?

<p>Performing O-Glycosylation (C)</p> Signup and view all the answers

What is the primary symptom of sickle cell anemia as described in the text?

<p>Episodes of pain (D)</p> Signup and view all the answers

Which organelle is primarily associated with synthesizing proteins meant for export from the cell?

<p>Rough endoplasmic reticulum (A)</p> Signup and view all the answers

Which protein synthesis mutation leads to the codon containing the changed base becoming a termination codon?

<p>Nonsense mutation (C)</p> Signup and view all the answers

What is the role of phosphorylation in post-translational modifications of proteins?

<p>Affecting protein-protein interactions (D)</p> Signup and view all the answers

Which process contributes to protein maturation by promoting folding and stabilizing proteins?

<p>O-glycosylation (B)</p> Signup and view all the answers

In humans, what is the main cause of sickle cell anemia?

<p>Single nucleotide substitution in the gene for beta-globin (B)</p> Signup and view all the answers

What is the impact of a nonsense mutation in protein synthesis?

<p>Altering the amino acid sequence (A)</p> Signup and view all the answers

What is the role of the signal recognition particle (SRP) in eukaryotic cells during protein synthesis?

<p>Transfers ribosomes with polypeptides to the ER (B)</p> Signup and view all the answers

What is the primary function of targeting signals in protein synthesis?

<p>Direct cellular transport for protein destination (A)</p> Signup and view all the answers

How does hydroxylation contribute to post-translational modifications of proteins?

<p>Increases protein stability (A)</p> Signup and view all the answers

What is the role of GTP in the process of protein synthesis?

<p>Provides energy for the movement of the ribosome along the mRNA (D)</p> Signup and view all the answers

In protein translation, what does the P site of the ribosome primarily do?

<p>Generates the peptide bond between amino acids (A)</p> Signup and view all the answers

Which component guarantees translation during protein synthesis by helping form each peptide bond?

<p>High-energy phosphate equivalents from CTP (C)</p> Signup and view all the answers

What is the primary role of the E site of the ribosome during protein synthesis?

<p>Occupying the empty tRNA about to exit (B)</p> Signup and view all the answers

What is the purpose of folding and post-translational modifications (PTM) in protein synthesis?

<p>Ensure polypeptides fold into active, 3-dimensional forms (D)</p> Signup and view all the answers

Which component is responsible for binding an incoming Aminoacyl-tRNA according to the codon in the ribosome?

<p>Aminoacyl-tRNA synthetases (A)</p> Signup and view all the answers

What is the main role of the Golgi apparatus in protein synthesis?

<p>Facilitating protein folding (B)</p> Signup and view all the answers

Which organelle is associated with synthesizing proteins intended for export from the cell?

<p>Endoplasmic reticulum (A)</p> Signup and view all the answers

What is the consequence of phosphorylation as a post-translational modification of proteins?

<p>Promotes protein folding (D)</p> Signup and view all the answers

In protein biosynthesis, what is the function of hydroxylation as a post-translational modification?

<p>Increases protein stability (A)</p> Signup and view all the answers

What is the primary consequence of a nonsense mutation during protein synthesis?

<p>Premature termination of translation (A)</p> Signup and view all the answers

What is the primary function of N-glycosylation in post-translational modifications?

<p>Enhancing protein folding (D)</p> Signup and view all the answers

What type of mutation involves a change in one amino acid of the β-globin protein from glutamic acid to valine (E22V)?

<p>Point mutation (A)</p> Signup and view all the answers

What type of mutation causes large-scale changes to proteins by either deleting or inserting 1 or 2 nucleotides?

<p>Frame-shift mutation (D)</p> Signup and view all the answers

Which mutation type involves changes in 'introns' removal from pre-mRNA, resulting in aberrant protein production?

<p>Splice site mutation (D)</p> Signup and view all the answers

What process is responsible for errors during DNA replication and damage to DNA by mutagens like radiation and carcinogens?

<p>DNA mutation (B)</p> Signup and view all the answers

Which factor is likely to lead to spontaneous mutations by causing DNA damage and mutations?

<p>Errors during DNA replication (B)</p> Signup and view all the answers

What is the outcome of a newly synthesized protein?

<p>Addition of a 5 cap (C)</p> Signup and view all the answers

Which characteristic describes the genetic code as being nonoverlapping and commaless?

<p>Nonoverlapping &amp; commaless (D)</p> Signup and view all the answers

What is the main cause of sickle cell anemia in humans?

<p>Replacement of adenine with guanine in DNA (A)</p> Signup and view all the answers

What is the primary function of the 3 poly-adenylation tail in eukaryote genomes?

<p>Enhancing stability during transcription (D)</p> Signup and view all the answers

In protein synthesis, what role does the splicing step during post-transcriptional modification involve?

<p>Removal of non-coding sequences (B)</p> Signup and view all the answers

What type of nucleotides pair together in RNA?

<p>Adenine-Uracil &amp; Cytosine-Guanine (A)</p> Signup and view all the answers

What is the main purpose of protein sorting in the context of cell biology?

<p>Targeting proteins to their appropriate destinations inside or outside of the cell (B)</p> Signup and view all the answers

Which post-translational modification involves adding an acetyl group to proteins as described in the text?

<p>Methylation (A)</p> Signup and view all the answers

In the context of protein synthesis, how does lipidation impact proteins?

<p>Enhances binding affinity to biological membranes (C)</p> Signup and view all the answers

What is a significant consequence of errors in protein sorting within a cell?

<p>Development of certain diseases (A)</p> Signup and view all the answers

Which process contributes to protein maturation by promoting proper folding and stability?

<p>Trimming (B)</p> Signup and view all the answers

What is the primary function of acetylation in post-translational modifications of proteins?

<p>Regulates gene expression (D)</p> Signup and view all the answers

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