Cellular Adaptations: Atrophy and Hypertrophy
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Questions and Answers

Which test is preferred for diagnosing Myocardial Infarction?

  • ESR
  • Troponin T & I (correct)
  • CK-MB
  • CRP
  • What symptom is commonly associated with inflammation?

  • Decreased WBCs
  • Decreased HR
  • Increased ESR (correct)
  • Decreased CRP
  • What is the normal range of WBC count in a complete blood count?

  • 5000 to 10000 cells/mmm (correct)
  • 1000 to 5000 cells/mmm
  • 7000 to 12000 cells/mmm
  • 3000 to 7000 cells/mmm
  • Which inflammatory marker is elevated in tissue necrosis?

    <p>ESR</p> Signup and view all the answers

    Which of these is NOT a symptom of inflammation?

    <p>Increased WBCs</p> Signup and view all the answers

    Which enzyme level is elevated due to pancreatic damage?

    <p>Amylase</p> Signup and view all the answers

    Which key is situated between the 'A' key and the 'D' key on the keyboard?

    <p>S</p> Signup and view all the answers

    Which key is used to exit the current screen or function on a laptop?

    <p>Escape</p> Signup and view all the answers

    Which inflammatory marker is associated with tissue necrosis?

    <p>CRP</p> Signup and view all the answers

    What is the role of the CK-MB test in diagnosing myocardial infarction?

    <p>Measures enzyme levels that indicate heart muscle damage</p> Signup and view all the answers

    Study Notes

    Cellular Adaptations

    • Atrophy: cell shrinkage resulting from decreased functional demands or chronic ischemia
      • Causes: disuse, ischemia, infarction, nutrient starvation, denervation, and interruption of endocrine glands
    • Hypertrophy: increase in cell mass accompanied by augmented functional capacity
      • Often accompanied by hyperplasia (increase in cell numbers)
      • Results from net increase in cellular protein content due to increased functional demands
      • Important for cells that cannot undergo mitosis (e.g., muscle cells)

    Hyperplasia

    • Increase in cell numbers
      • Usually occurs in cells that can undergo mitosis
      • Results from increased physical demands and hormonal stimulations

    Metaplasia

    • Replacement of one normal differentiated cell type with another normal differentiated cell type
      • Cause/results from adaptation to persistent injury
      • Can progress to cancer (e.g., in cigarette smokers)
      • Fully reversible when stimulation is removed

    Dysplasia

    • Disorganized appearance of cells due to abnormal variations in size, shape, and arrangements
      • Adaptive effort gone astray
      • Significant potential to transform to cancer cells (pre-neoplastic lesions)
      • Severe dysplasia are called carcinoma in situ

    Necrosis

    • Infarction (cell death)
      • Results from ischemia or toxic injuries
      • Tissue unable to perform normal cellular function, inflammatory in nature
    • Types of necrosis: 4 (not specified)

    Inflammation

    • Symptoms: general malaise, fever, increased HR, increased WBCs, and loss of appetite
    • Markers: elevated ESR, CRP when there is tissue necrosis
    • Other markers: elevated amylase level (pancreatic damage), elevated creatine kinase (MB isoenzyme), and cardiac troponin (myocardial infarction)

    Diagnostic Tests

    • Troponin T & I (preferred test for myocardial infarction)
    • CK-MB (elevated when MI), levels fall after 24 hours

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    Description

    Learn about the causes of atrophy, a type of cell shrinkage, and hypertrophy, an increase in cell mass, including factors like disuse, ischemia, and nutrient starvation.

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