Cellular Adaptation and Injury Quiz
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Questions and Answers

Causes of cell injury can be divided into:

  • Hereditary causes
  • Acquired causes
  • Both A and B (correct)
  • None of the above
  • What is hypoxia?

    Shortage of oxygen

    Which of the following are physical agents that can cause cell injury?

  • Trauma
  • Burns
  • Deep cold
  • Radiation
  • All of the above (correct)
  • What do you think injured cells do?

    <p>All of the above (D)</p> Signup and view all the answers

    Cells encounter physiologic stress or pathologic stimuli and undergo adaptation (homeostasis).

    <p>True (A)</p> Signup and view all the answers

    Reversible injury is characterized by the ability of the cell to return to its normal state.

    <p>True (A)</p> Signup and view all the answers

    Which of the following can lead to cell death?

    <p>Necrosis or apoptosis (B)</p> Signup and view all the answers

    Cell death is the ultimate result of cell injury: Necrosis, Apoptosis, Pyroptosis, Autophagy..etc.

    <p>True (A)</p> Signup and view all the answers

    What are the two forms of cell death?

    <p>Both A and B (C)</p> Signup and view all the answers

    Which type of cell death marked by the blue arrow?

    <p>Necrosis (B)</p> Signup and view all the answers

    What is necrosis?

    <p>Local death of cells or tissues within the living body</p> Signup and view all the answers

    Match the stages of necrosis in the correct order:

    <p>Normal = 1 Pyknosis = 2 Karyohexis = 3 Karyolysis = 4</p> Signup and view all the answers

    Apoptosis: cytoplasmic blebs --> apoptotic bodies --> phagocytosis

    <p>True (A)</p> Signup and view all the answers

    The main difference between apoptosis & necrosis is that apoptosis occurs in an organized fashion and necrosis occurs without a nuclear signal/order.

    <p>True (A)</p> Signup and view all the answers

    Which of the following is a type of cellular adaptation?

    <p>All of the above (E)</p> Signup and view all the answers

    What is Hyperplasia?

    <p>Increase in cell number in specific tissue or organ leading to tissue or organ enlargement</p> Signup and view all the answers

    Physiologic hyperplasia includes:

    <p>Both A and B (A)</p> Signup and view all the answers

    What is Hypertrophy?

    <p>Increase in the cell size leading to enlargement of the tissue or organ</p> Signup and view all the answers

    Physiologic hypertrophy includes:

    <p>Both A and B (D)</p> Signup and view all the answers

    This lady has thyroid problem due to less iodine intake, which hypertrophy type you guess?

    <p>Pathologic (B)</p> Signup and view all the answers

    Causes of atrophy may include which of the following?

    <p>All of the above (E)</p> Signup and view all the answers

    Flashcards

    Causes of Cell Injury

    Factors that lead to damage in cells, can be hereditary or acquired.

    Hypoxia

    A condition where there is not enough oxygen for cells.

    Necrosis

    Pathologic cell death that causes inflammation in tissues.

    Apoptosis

    Controlled, programmed cell death that does not elicit inflammation.

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    Irreversible Cell Injury

    Injury that leads to cell death due to severe or persistent stimuli.

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    Reversible Cell Injury

    Cell injury that can be repaired and return to normal function.

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    Hyperplasia

    Increase in the number of cells, leading to tissue enlargement.

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    Hypertrophy

    Increase in cell size resulting in tissue enlargement.

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    Atrophy

    Decreased cell size due to reduced trophic influences or disuse.

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    Metaplasia

    Replacement of one cell type with another as an adaptive response.

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    Necrosis Types

    Forms of necrosis include coagulative, liquefactive, caseous, and fat necrosis.

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    Caseation Necrosis

    Type of necrosis that appears granular and is usually associated with TB.

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    Liquefactive Necrosis

    Necrosis where tissue become liquid due to neutrophil activity, often in CNS.

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    Coagulative Necrosis

    Type of necrosis where tissues maintain structure but cell outlines are ghostly.

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    Fat Necrosis

    Necrosis that leads to shadowy outlines of fat cells.

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    Pyroptosis

    A form of cell death associated with inflammation, distinct from apoptosis.

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    Cellular Adaptation

    Process by which cells adjust to changes to maintain function and viability.

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    Physiologic Hyperplasia

    Increase in cell number due to normal physiological conditions.

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    Pathologic Hyperplasia

    Abnormal increase in cell numbers due to disease processes.

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    Physiologic Hypertrophy

    Increase in cell size due to normal processes like exercise or pregnancy.

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    Pathologic Hypertrophy

    Abnormal increase in cell size due to disease, such as heart failure.

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    Atrophy Causes

    Causes of atrophy include aging, disuse, and decreased blood supply.

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    Brain Atrophy

    Progressive decrease in brain size, often seen with aging or diseases like Alzheimer's.

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    Neurogenic Atrophy

    Atrophy caused by nerve damage affecting muscle function.

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    Dysplasia

    Abnormal changes in cell size, shape, and organization, which can precede cancer.

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    Relationship of Metaplasia and Cancer

    Metaplasia can lead to dysplasia and may progress to cancer.

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    Cell Death Impact

    Cell death can lead to dysfunction and elicit inflammation or not, based on type.

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    Difference between Apoptosis and Necrosis

    Apoptosis is controlled and organized; necrosis is chaotic and unregulated.

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    Study Notes

    Cellular Adaptation

    • Cellular adaptation describes how cells respond to various stimuli, maintaining homeostasis or altering their structure and function.
    • Adaptation can be reversible, if the stimulus ceases, or irreversible, leading to cell death.

    Causes of Cell Injury

    • Cell injury can be caused by a variety of factors grouped as hereditary or acquired.
    • Hypoxia (oxygen deprivation) is a common cause.
    • Physical agents like trauma, burns, radiation, and extreme temperatures.
    • Chemicals, including high concentrations of specific substances, alcohol, and smoke.
    • Infectious agents, such as bacteria and viruses.
    • Immunological reactions, for example, eczema or systemic lupus erythematosus (SLE).
    • Genetic mutations.

    Morphogenesis of Cell and Intercellular Matrix Injury

    • Infiltration: Excessive accumulation of metabolites in cells and the surrounding matrix.
    • Decomposition (phanerosis): Breakdown of cellular and extracellular membranes.
    • Perverted synthesis: Production of abnormal substances incompatible with normal cellular/tissue function.
    • Transformation of initial metabolites to atypical end products.

    Cell Injury

    • Cells encounter physiologic or pathologic stimuli adapting to preserve viability and function.
    • Reversible cell injury is when cells can revert to their normal state after the stimulus ceases, including processes like hyperplasia, hypertrophy, atrophy, and metaplasia.
    • Irreversible injury means the cell can't recover, resulting in cell death (necrosis or apoptosis).
    • The outcome of cell injury depends on the type, severity, and duration of the injury, and the specific cell type.

    Irreversible Cell Injury

    • Severe or persistent stimuli result in irreversible cell injury.
    • Ultimate cell death can occur through necrosis, apoptosis, pyroptosis, or autophagy.
    • Necrosis is a pathological process associated with inflammation.
    • Apoptosis is a programmed cell death regulated by specific biochemical processes.
    • Necrosis vs. Apoptosis: Necrosis is unorganized/chaotic and inflammatory, whereas apoptosis is ordered/regulated and doesn’t evoke inflammation. Necrosis causes cells and their contents to spill out into the tissue.

    Necrosis

    • Necrosis is a form of cell death characterized by the breakdown of cellular components.
    • It leads to the disruption of cell membranes and the release of cellular contents causing inflammation.
    • Necrosis is a pathological process and associated with various types including coagulative, liquefactive, caseous, and fat necrosis.

    Apoptosis

    • Apoptosis is a programmed cell death process crucial for development and homeostasis.
    • It involves cytoplasmic blebbing, formation of apoptotic bodies, resulting in phagocytosis.
    • It's a regulated process and does not cause inflammation.
    • Apoptosis might indicate DNA damage and apoptosis failure may lead to cancerous phenotypes.

    Cell Adaptation Processes

    • Hyperplasia is an increase in the number of cells.
      • Physiological: Occurs during normal development or in response to specific physiological stimuli (hormonal hyperplasia, compensatory hyperplasia)
      • Pathological: Occurs due to aberrant signals (hormonal hyperplasia, viral infections)
    • Hypertrophy is an increase in the size of cells.
      • Physiological: Skeletal muscle hypertrophy due to exercise
      • Pathologic: Cardiac hypertrophy due to hypertension
    • Atrophy: Reduction in cell size.
      • Physiological: Normal aging
      • Pathological: Loss of trophic hormones, diminished blood supply, nerve injury, or disuse
    • Metaplasia: Replacing one cell type with another as an adaptive strategy.
      • Pathological (often): Replacement of respiratory columnar cells to squamous cells when exposed to irritants

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    Description

    This quiz explores the concepts of cellular adaptation, causes of cell injury, and the morphogenesis of cell and intercellular matrix injury. Learn how cells respond to various stimuli and the factors that can lead to their injury. Test your knowledge about cellular responses and mechanisms underlying injury.

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