Podcast
Questions and Answers
What type of blood cells are primarily involved in the innate immune response?
What type of blood cells are primarily involved in the innate immune response?
Which statement about neutrophils is true?
Which statement about neutrophils is true?
What is the process by which all leukocytes are generated?
What is the process by which all leukocytes are generated?
Which of the following is NOT a type of myeloid cell?
Which of the following is NOT a type of myeloid cell?
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What defines the staining characteristics of neutrophils?
What defines the staining characteristics of neutrophils?
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Study Notes
Cells of the Immune System
- Leukocytes are the main cells of the immune system
- Lymphocytes are part of the lymphoid lineage
- Several types of lymphocytes exist
- Myeloid lineage contains:
- Dendritic cells
- Monocytes/Macrophages
- Granulocytes
- Lymphocytes are part of the lymphoid lineage
Haematopoiesis
- All leukocytes are generated in primary lymphoid tissue by the process of haematopoiesis
- Lymphoid and myeloid cells follow different differentiation pathways
- Haematopoietic stem cell (HSC) is the origin of both lymphoid and myeloid cells
Granulocytes
- Front line of attack during an immune response, part of the innate immune system
- Identified by characteristic staining patterns of “granules”
- Released in contact with pathogens
- Contain proteins with distinct functions: killing, regulation of other cells, tissue remodeling
- All have multilobed nuclei
Neutrophils
- One of the main effector cells in the innate immune system
- Constitutes 50-70% of white blood cells
- Released from bone marrow, circulate for 7-10 hours, enter tissues, live only a few days
- Numbers and recruitment increase during infections, called "leukocytosis"
- Identified by phagocytosis of microorganisms
- Main cellular component of pus
Neutrophil Characteristics
- Named based on staining qualities of granules
- Multilobed nucleus is called a polymorphonuclear leukocyte (PMN)
- Neutrophilic granules stain lightly blue to pink
- Spend 7-10 hours in the blood before migrating into tissues
- First responders, motile and phagocytic
- "Leukocytosis" indicates infection
- Release extracellular "traps"
Basophils
- Basophils are part of the granulocyte lineage
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Description
Test your knowledge on the different cells of the immune system, including leukocytes, lymphocytes, and granulocytes. This quiz covers their functions, origins, and the process of haematopoiesis. Perfect for students studying immunology or related subjects.
