Cell Suicide: Apoptosis

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Questions and Answers

What is one of the features induced by specific Bcl-2 proteins during apoptosis?

  • Increase in cell volume
  • Loss of mitochondrial function (correct)
  • Enhanced mitochondrial function
  • Caspase deactivation

Which process follows the activation of initial caspases during apoptosis?

  • Decrease in membrane permeability
  • Release of cytochrome c into the nucleus
  • Inhibition of DNA fragmentation
  • Activation of a cascade of other caspases (correct)

What contributes to the shrinkage of nuclear and cell volumes during apoptosis?

  • Increased lipid mobility
  • Destruction of the cytoskeleton and chromatin (correct)
  • Mitochondrial fusion
  • Enhanced cytoskeleton integrity

How are apoptotic cells identified histochemically?

<p>By the presence of labeled nucleotides at new DNA ends (D)</p> Signup and view all the answers

What role does apoptosis play in the final development of the central nervous system?

<p>Elimination of excess nerve cells (C)</p> Signup and view all the answers

Which protein triggers apoptosis for eliminating cells blocked by lack of nutrients or damage?

<p>p53 and other tumor suppressor proteins (D)</p> Signup and view all the answers

What is the process of cell suicide called?

<p>Apoptosis (B)</p> Signup and view all the answers

How do apoptotic bodies get eliminated?

<p>Undergoing phagocytosis (B)</p> Signup and view all the answers

Why is the release of cellular components avoided during apoptosis?

<p>To prevent local inflammatory reaction (A)</p> Signup and view all the answers

In cancer cells, which genes are often deactivated to prevent elimination through apoptosis?

<p>Genes controlling apoptosis (A)</p> Signup and view all the answers

What family of proteins controls the onset of apoptosis?

<p>Bcl-2 family (C)</p> Signup and view all the answers

What triggers the local inflammatory reaction and immigration of leukocytes in injured cells?

<p>Necrosis (A)</p> Signup and view all the answers

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