Cell Suicide: Apoptosis
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Questions and Answers

What is one of the features induced by specific Bcl-2 proteins during apoptosis?

  • Increase in cell volume
  • Loss of mitochondrial function (correct)
  • Enhanced mitochondrial function
  • Caspase deactivation
  • Which process follows the activation of initial caspases during apoptosis?

  • Decrease in membrane permeability
  • Release of cytochrome c into the nucleus
  • Inhibition of DNA fragmentation
  • Activation of a cascade of other caspases (correct)
  • What contributes to the shrinkage of nuclear and cell volumes during apoptosis?

  • Increased lipid mobility
  • Destruction of the cytoskeleton and chromatin (correct)
  • Mitochondrial fusion
  • Enhanced cytoskeleton integrity
  • How are apoptotic cells identified histochemically?

    <p>By the presence of labeled nucleotides at new DNA ends</p> Signup and view all the answers

    What role does apoptosis play in the final development of the central nervous system?

    <p>Elimination of excess nerve cells</p> Signup and view all the answers

    Which protein triggers apoptosis for eliminating cells blocked by lack of nutrients or damage?

    <p>p53 and other tumor suppressor proteins</p> Signup and view all the answers

    What is the process of cell suicide called?

    <p>Apoptosis</p> Signup and view all the answers

    How do apoptotic bodies get eliminated?

    <p>Undergoing phagocytosis</p> Signup and view all the answers

    Why is the release of cellular components avoided during apoptosis?

    <p>To prevent local inflammatory reaction</p> Signup and view all the answers

    In cancer cells, which genes are often deactivated to prevent elimination through apoptosis?

    <p>Genes controlling apoptosis</p> Signup and view all the answers

    What family of proteins controls the onset of apoptosis?

    <p>Bcl-2 family</p> Signup and view all the answers

    What triggers the local inflammatory reaction and immigration of leukocytes in injured cells?

    <p>Necrosis</p> Signup and view all the answers

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