12 Questions
What is one of the features induced by specific Bcl-2 proteins during apoptosis?
Loss of mitochondrial function
Which process follows the activation of initial caspases during apoptosis?
Activation of a cascade of other caspases
What contributes to the shrinkage of nuclear and cell volumes during apoptosis?
Destruction of the cytoskeleton and chromatin
How are apoptotic cells identified histochemically?
By the presence of labeled nucleotides at new DNA ends
What role does apoptosis play in the final development of the central nervous system?
Elimination of excess nerve cells
Which protein triggers apoptosis for eliminating cells blocked by lack of nutrients or damage?
p53 and other tumor suppressor proteins
What is the process of cell suicide called?
Apoptosis
How do apoptotic bodies get eliminated?
Undergoing phagocytosis
Why is the release of cellular components avoided during apoptosis?
To prevent local inflammatory reaction
In cancer cells, which genes are often deactivated to prevent elimination through apoptosis?
Genes controlling apoptosis
What family of proteins controls the onset of apoptosis?
Bcl-2 family
What triggers the local inflammatory reaction and immigration of leukocytes in injured cells?
Necrosis
Learn about the process of cell suicide known as apoptosis, which is important for eliminating defective and unneeded cells in the body. Explore how apoptosis is a rapid and highly regulated cellular activity that results in the formation of membrane-enclosed apoptotic bodies.
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