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12 Questions

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Cell Suicide: Apoptosis

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Questions and Answers

What is one of the features induced by specific Bcl-2 proteins during apoptosis?

Increase in cell volume

Loss of mitochondrial function (correct)

Enhanced mitochondrial function

Caspase deactivation

Which process follows the activation of initial caspases during apoptosis?

Decrease in membrane permeability

Release of cytochrome c into the nucleus

Inhibition of DNA fragmentation

Activation of a cascade of other caspases (correct)

What contributes to the shrinkage of nuclear and cell volumes during apoptosis?

Increased lipid mobility

Destruction of the cytoskeleton and chromatin (correct)

Mitochondrial fusion

Enhanced cytoskeleton integrity

How are apoptotic cells identified histochemically?

By the presence of labeled nucleotides at new DNA ends Signup and view all the answers

What role does apoptosis play in the final development of the central nervous system?

Elimination of excess nerve cells Signup and view all the answers

Which protein triggers apoptosis for eliminating cells blocked by lack of nutrients or damage?

p53 and other tumor suppressor proteins Signup and view all the answers

What is the process of cell suicide called?

Apoptosis Signup and view all the answers

How do apoptotic bodies get eliminated?

Undergoing phagocytosis Signup and view all the answers

Why is the release of cellular components avoided during apoptosis?

To prevent local inflammatory reaction Signup and view all the answers

In cancer cells, which genes are often deactivated to prevent elimination through apoptosis?

Genes controlling apoptosis Signup and view all the answers

What family of proteins controls the onset of apoptosis?

Bcl-2 family Signup and view all the answers

What triggers the local inflammatory reaction and immigration of leukocytes in injured cells?

Necrosis Signup and view all the answers