18 Questions
What type of cells contain all the necessary genetic information to generate a whole organism?
Differentiated somatic cells
Which process involves the egg cell reprogramming somatic cell nuclei?
Cell reprogramming
What is the main purpose of using Integrating systems or Non-integrating systems in generating iPSCs?
Delivery of transcription factors
Which of the following transcription factors was NOT part of the pool of 24 factors used for generating iPSCs?
Antennapedia
What was the year when the discovery of 'master' Transcription Factors that determine and restrict cell fate to a specific lineage was made?
1987
What is the key process that differentiates iPSCs from other cell types?
Cell differentiation
Which specific genes are involved in determining morphological and functional specialization of differentiated cells?
Oct3/4, Sox2, Klf4, c-Myc
What is the key information needed to differentiate stem cells into specific cell types in the laboratory?
Expression of master transcription factors
Which process involves the expression of genes associated with specific functions of each cell, like actin and myosin?
Cell reprogramming
What does silencing of pluripotency genes expression contribute to in the context of stem cell differentiation?
Differentiation potential
Which factor is essential for skeletal muscle differentiation?
MyoD
What dictates the cellular morphology and function based on the combination of activated or repressed genes?
Waddington's epigenetic landscape
Which type of stem cells are derived from the inner cell mass of the blastocyst?
Embryonic stem cells (ESCs)
What is the key feature of induced pluripotent stem cells (iPSCs)?
Pluripotency after reprogramming
Which scientific discovery contributed to the development of induced pluripotent stem cells (iPSCs)?
Identification of master transcription factors in 1987
What is the significance of the 'Yamanaka factors' in stem cell research?
Responsible for maintaining ESC pluripotency
What did studies on reprogramming by nuclear transfer or somatic cell cloning demonstrate?
Differentiated cells contain required genetic information
Which type of stem cells are sourced from a variety of tissues and organs, including fetal and adult sources?
Non-embryonic stem cells
Test your knowledge on reprogramming techniques such as somatic cell nuclear transfer, induced pluripotent stem cells (iPSCs), and culture conditions for maintaining pluripotency in mouse and human embryonic stem cells. Learn about key milestones like Ian Wilmut's work on Dolly the sheep and the reprogramming studies related to Antennapedia.
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