5 Questions
What is the term for the phenomenon where repeated administration of a drug results in a diminished effect?
Tachyphylaxis
How do spare receptors contribute to signal duration and intensity?
A single ligand receptor complex can interact with many G proteins
What happens to receptors when they undergo endocytosis?
They are sequestered from further agonist interaction
What characterizes systems that exhibit spare receptors behavior?
They have the ability to amplify signal duration & intensity
What is one of the mechanisms evolved to protect a cell from excessive stimulation?
The receptors may be still & become unresponsive to the ligand.
This quiz covers the different mechanisms that cells employ to protect themselves from excessive stimulation by down-regulating and making receptors unresponsive to ligands. It also discusses the molecular changes that lead to receptor endocytosis and sequestration.
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