Lecture 7: Cell Migration
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Questions and Answers

What is the role of Type I INF stimulated genes in inhibiting viral replication?

  • Accelerate viral infection by facilitating transcription and translation
  • Enhance viral replication by increasing viral gene expression
  • Promote transcription and translation of viral genes
  • Block transcription and translation of viral genes (correct)

Which process involves the recruitment of monocytes and neutrophils to the site of infection?

  • Transcription
  • Migration (correct)
  • Costimulation
  • Diapedesis

What causes the process of diapedesis to occur?

  • Conformation change in adhesion molecules of leukocytes (correct)
  • Migration of dendritic cells
  • Translocation of transcription factors into the nucleus
  • Increased expression of adhesion molecules

Which molecule triggers migration and targeting of dendritic cells to lymphoid tissue?

<p>PAMP (C)</p> Signup and view all the answers

What is the first step in the recruitment of leukocytes to the site of infection?

<p>Migration along the vascular endothelium (C)</p> Signup and view all the answers

Which family of molecules are absolutely necessary for the recruitment of monocytes to the site of infection?

<p>Selectins (C)</p> Signup and view all the answers

What causes cells to cross from the lumen of a vessel into the surrounding tissue?

<p>Diapedesis (A)</p> Signup and view all the answers

What leads to the activation of transcription factors like IRF3 in the cytoplasm?

<p>Binding of PAMP to intracellular TLR (B)</p> Signup and view all the answers

What leads to a tight binding between leukocytes and adhesion molecules?

<p>Conformation change in adhesion molecules (C)</p> Signup and view all the answers

What causes heat, redness, swelling, and pain at the site of infection?

<p>Vasodilation due to chemokine binding (C)</p> Signup and view all the answers

Which molecules provide Signal 2 for T cells in lymphoid tissue?

<p>Costimulatory molecules (C)</p> Signup and view all the answers

What is the difference between CC and CXC chemokines?

<p>The location of two cysteine residues (B)</p> Signup and view all the answers

Which cytokines help induce inflammation and are considered pro-inflammatory?

<p>IL-6 and TNF-a (B)</p> Signup and view all the answers

In T cell activation, how many signals are required?

<p>3 signals (C)</p> Signup and view all the answers

What do Type I IFN bind to for triggering another signaling cascade?

<p>Their own receptors (C)</p> Signup and view all the answers

Which molecules are secreted out of the cell from PRR signaling?

<p>Chemokines and cytokines (B)</p> Signup and view all the answers

Where are costimulatory molecules B7.1 and B7.2 found to provide Signal 2 for T cells?

<p>Everywhere in the body (A)</p> Signup and view all the answers

Which chemokine is an example of CC chemokines?

<p>(CCL2) (D)</p> Signup and view all the answers

What is the role of Type I IFN?

<p>Act as an anti-viral cytokine (B)</p> Signup and view all the answers

Which molecules help in enhanced migration to secondary lymphoid organs?

<p>Adhesion molecules (C)</p> Signup and view all the answers

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