Lecture 7: Cell Migration

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What is the role of Type I INF stimulated genes in inhibiting viral replication?

Accelerate viral infection by facilitating transcription and translation

Enhance viral replication by increasing viral gene expression

Promote transcription and translation of viral genes

Block transcription and translation of viral genes (correct)

Which process involves the recruitment of monocytes and neutrophils to the site of infection?

Transcription

Migration (correct)

Costimulation

Diapedesis

What causes the process of diapedesis to occur?

Conformation change in adhesion molecules of leukocytes (correct)

Migration of dendritic cells

Translocation of transcription factors into the nucleus

Increased expression of adhesion molecules

Which molecule triggers migration and targeting of dendritic cells to lymphoid tissue?

PAMP Signup and view all the answers

What is the first step in the recruitment of leukocytes to the site of infection?

Migration along the vascular endothelium Signup and view all the answers

Which family of molecules are absolutely necessary for the recruitment of monocytes to the site of infection?

Selectins Signup and view all the answers

What causes cells to cross from the lumen of a vessel into the surrounding tissue?

Diapedesis Signup and view all the answers

What leads to the activation of transcription factors like IRF3 in the cytoplasm?

Binding of PAMP to intracellular TLR Signup and view all the answers

What leads to a tight binding between leukocytes and adhesion molecules?

Conformation change in adhesion molecules Signup and view all the answers

What causes heat, redness, swelling, and pain at the site of infection?

Vasodilation due to chemokine binding Signup and view all the answers

Which molecules provide Signal 2 for T cells in lymphoid tissue?

Costimulatory molecules Signup and view all the answers

What is the difference between CC and CXC chemokines?

The location of two cysteine residues Signup and view all the answers

Which cytokines help induce inflammation and are considered pro-inflammatory?

IL-6 and TNF-a Signup and view all the answers

In T cell activation, how many signals are required?

3 signals Signup and view all the answers

What do Type I IFN bind to for triggering another signaling cascade?

Their own receptors Signup and view all the answers

Which molecules are secreted out of the cell from PRR signaling?

Chemokines and cytokines Signup and view all the answers

Lecture 7: Cell Migration

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Questions and Answers

What is the role of Type I INF stimulated genes in inhibiting viral replication?

Which process involves the recruitment of monocytes and neutrophils to the site of infection?

What causes the process of diapedesis to occur?

Which molecule triggers migration and targeting of dendritic cells to lymphoid tissue?

What is the first step in the recruitment of leukocytes to the site of infection?

Which family of molecules are absolutely necessary for the recruitment of monocytes to the site of infection?

What causes cells to cross from the lumen of a vessel into the surrounding tissue?

What leads to the activation of transcription factors like IRF3 in the cytoplasm?

What leads to a tight binding between leukocytes and adhesion molecules?

What causes heat, redness, swelling, and pain at the site of infection?

Which molecules provide Signal 2 for T cells in lymphoid tissue?

What is the difference between CC and CXC chemokines?

Which cytokines help induce inflammation and are considered pro-inflammatory?

In T cell activation, how many signals are required?

What do Type I IFN bind to for triggering another signaling cascade?

Which molecules are secreted out of the cell from PRR signaling?

Where are costimulatory molecules B7.1 and B7.2 found to provide Signal 2 for T cells?

Which chemokine is an example of CC chemokines?

What is the role of Type I IFN?

Which molecules help in enhanced migration to secondary lymphoid organs?

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