Lecture 7: Cell Migration
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Questions and Answers

What is the role of Type I INF stimulated genes in inhibiting viral replication?

  • Accelerate viral infection by facilitating transcription and translation
  • Enhance viral replication by increasing viral gene expression
  • Promote transcription and translation of viral genes
  • Block transcription and translation of viral genes (correct)
  • Which process involves the recruitment of monocytes and neutrophils to the site of infection?

  • Transcription
  • Migration (correct)
  • Costimulation
  • Diapedesis
  • What causes the process of diapedesis to occur?

  • Conformation change in adhesion molecules of leukocytes (correct)
  • Migration of dendritic cells
  • Translocation of transcription factors into the nucleus
  • Increased expression of adhesion molecules
  • Which molecule triggers migration and targeting of dendritic cells to lymphoid tissue?

    <p>PAMP</p> Signup and view all the answers

    What is the first step in the recruitment of leukocytes to the site of infection?

    <p>Migration along the vascular endothelium</p> Signup and view all the answers

    Which family of molecules are absolutely necessary for the recruitment of monocytes to the site of infection?

    <p>Selectins</p> Signup and view all the answers

    What causes cells to cross from the lumen of a vessel into the surrounding tissue?

    <p>Diapedesis</p> Signup and view all the answers

    What leads to the activation of transcription factors like IRF3 in the cytoplasm?

    <p>Binding of PAMP to intracellular TLR</p> Signup and view all the answers

    What leads to a tight binding between leukocytes and adhesion molecules?

    <p>Conformation change in adhesion molecules</p> Signup and view all the answers

    What causes heat, redness, swelling, and pain at the site of infection?

    <p>Vasodilation due to chemokine binding</p> Signup and view all the answers

    Which molecules provide Signal 2 for T cells in lymphoid tissue?

    <p>Costimulatory molecules</p> Signup and view all the answers

    What is the difference between CC and CXC chemokines?

    <p>The location of two cysteine residues</p> Signup and view all the answers

    Which cytokines help induce inflammation and are considered pro-inflammatory?

    <p>IL-6 and TNF-a</p> Signup and view all the answers

    In T cell activation, how many signals are required?

    <p>3 signals</p> Signup and view all the answers

    What do Type I IFN bind to for triggering another signaling cascade?

    <p>Their own receptors</p> Signup and view all the answers

    Which molecules are secreted out of the cell from PRR signaling?

    <p>Chemokines and cytokines</p> Signup and view all the answers

    Where are costimulatory molecules B7.1 and B7.2 found to provide Signal 2 for T cells?

    <p>Everywhere in the body</p> Signup and view all the answers

    Which chemokine is an example of CC chemokines?

    <p>(CCL2)</p> Signup and view all the answers

    What is the role of Type I IFN?

    <p>Act as an anti-viral cytokine</p> Signup and view all the answers

    Which molecules help in enhanced migration to secondary lymphoid organs?

    <p>Adhesion molecules</p> Signup and view all the answers

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