Cell Membrane Transport Quiz

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Questions and Answers

Which factor does NOT affect the magnitude of diffusion across the cell membrane?

  • Concentration gradient
  • Surface area for diffusion
  • Membrane thickness
  • Temperature of the cytoplasm (correct)

What is the correct equation representing the net rate of diffusion (J) across the cell membrane?

  • J = A * D * X / Ac
  • J = D * A * Ac / X (correct)
  • J = D / (A * Ac * X)
  • J = D * (A + Ac) / X

Which is NOT a mechanism of passive transport across the cell membrane?

  • Osmosis
  • Facilitated diffusion
  • Primary active transport (correct)
  • Simple diffusion

What term describes the movement of molecules from a region of lower concentration to a region of higher concentration?

<p>Active transport (C)</p> Signup and view all the answers

Which type of diffusion does NOT involve the assistance of a carrier protein?

<p>Simple diffusion (B)</p> Signup and view all the answers

Which statement about osmosis is incorrect?

<p>It involves the movement of solute molecules. (D)</p> Signup and view all the answers

In which type of active transport is energy directly consumed to move substances across the membrane?

<p>Primary active transport (C)</p> Signup and view all the answers

What is the purpose of endocytosis in cell membrane transport?

<p>To absorb substances into the cell (C)</p> Signup and view all the answers

What factor does NOT influence the net rate of diffusion of oxygen across the pulmonary membrane?

<p>Temperature of the inspired air (B)</p> Signup and view all the answers

Which substances primarily require transport proteins to cross the lipid bilayer?

<p>Large uncharged molecules (C)</p> Signup and view all the answers

Which statement best describes facilitated diffusion?

<p>It involves structural changes in transport proteins. (A)</p> Signup and view all the answers

What process describes the diffusion of ions through ion channels?

<p>Simple diffusion (A)</p> Signup and view all the answers

In the context of diffusion, what is the significance of the Donnan effect?

<p>It explains the unequal distribution of diffusible ions. (D)</p> Signup and view all the answers

Which of the following substances can diffuse rapidly across the lipid bilayer?

<p>Lipid soluble molecules (A)</p> Signup and view all the answers

What happens to oxygen diffusion if the area available for diffusion decreases?

<p>Oxygen diffusion will decrease significantly. (C)</p> Signup and view all the answers

Which type of molecules utilizes aquaporins for transport across cell membranes?

<p>Water molecules (B)</p> Signup and view all the answers

What is the primary function of the sodium-potassium pump in cellular transport?

<p>It extrudes 3 Na+ out of the cell while bringing 2 K+ in. (B)</p> Signup and view all the answers

Which characteristic is NOT associated with primary active transport mechanisms?

<p>Passive movement of solutes. (B)</p> Signup and view all the answers

How does the sodium-potassium pump contribute to the electrogenic nature of the cell membrane?

<p>By creating a charge imbalance due to the different number of Na+ and K+ transported. (C)</p> Signup and view all the answers

In which scenario is solvent drag most appreciable?

<p>Across the kidney glomeruli. (B)</p> Signup and view all the answers

What defines the coupling ratio of the sodium-potassium pump?

<p>3 Na+ for every 2 K+ transported. (C)</p> Signup and view all the answers

What role does Ca-ATPase play in muscle cells?

<p>It pumps Ca2+ out of the cytoplasm leading to muscle relaxation. (D)</p> Signup and view all the answers

What is solvent drag primarily associated with in the context of filtration?

<p>The high surface area and permeability of the filtering membrane. (D)</p> Signup and view all the answers

What effect does phosphorylation have in the operation of the sodium-potassium pump?

<p>It facilitates the binding of Na+ ions to the alpha subunit. (B)</p> Signup and view all the answers

What characterizes the process of nonionic diffusion?

<p>It involves the diffusion of undissociated weak acids and bases. (B)</p> Signup and view all the answers

What is the definition of osmotic pressure?

<p>The pressure necessary to prevent the movement of water across a membrane. (A)</p> Signup and view all the answers

Why does a hyperosmolar solution of NaCl exert osmotic effects on cells?

<p>Sodium is not able to diffuse easily across the cell membrane. (A)</p> Signup and view all the answers

How does osmosis occur in relation to solute concentration?

<p>Water flows from areas of low solute concentration to high solute concentration. (B)</p> Signup and view all the answers

What is true regarding ultrafiltration in capillary walls?

<p>Pressure differences between capillary and interstitial fluid drive the process. (D)</p> Signup and view all the answers

In which scenario would urea not exert an osmotic effect?

<p>If it is in equilibrium with cell interior concentrations. (C)</p> Signup and view all the answers

What prevents the diffusion of weak acids and bases in their ionic forms?

<p>The membrane's permeability to ionic particles. (A)</p> Signup and view all the answers

What best describes oncotic pressure?

<p>The drawing force exerted by plasma proteins alone. (C)</p> Signup and view all the answers

What role do V-ATPases play in cellular function?

<p>They transport protons out of the cytoplasm into organelles such as lysosomes. (C)</p> Signup and view all the answers

Which of the following best describes secondary active transport?

<p>Couples the transport of a substance with Na+ driven by the Na-K pump. (A)</p> Signup and view all the answers

What process is characterized by the cell membrane folding inward to form a vesicle?

<p>Endocytosis (A)</p> Signup and view all the answers

What is the primary purpose of the sodium-dependent glucose transport in intestinal cells?

<p>To facilitate the uptake of glucose into cells using Na+ concentration gradient. (B)</p> Signup and view all the answers

Which statement regarding the sodium-calcium exchange mechanism is correct?

<p>Na+ moves down its electrochemical gradient while Ca²+ moves against its gradient. (D)</p> Signup and view all the answers

What is lost during the process of endocytosis?

<p>Membrane material surrounding the cell (B)</p> Signup and view all the answers

Which transport system directly influences the electrochemical gradient of sodium in cells?

<p>Na-K pump (A)</p> Signup and view all the answers

What is the function of sodium-dependent amino acid transporters in renal cells?

<p>They co-transport amino acids into renal cells when Na+ binds. (B)</p> Signup and view all the answers

Which of the following correctly describes the process of phagocytosis?

<p>It is the engulfment of large particulate matter by certain cells. (B)</p> Signup and view all the answers

What is immediately formed after the invagination of the cell membrane during pinocytosis?

<p>Pinocytic vacuole (C)</p> Signup and view all the answers

Which statement about exocytosis is true?

<p>It results in the expulsion of cellular secretions. (D)</p> Signup and view all the answers

Which of the following components plays a crucial role in the docking of secretory vesicles during exocytosis?

<p>Calcium ions (Ca2+) (D)</p> Signup and view all the answers

In which process are the contents of vacuoles expelled from the cell after digestion?

<p>Exocytosis (A)</p> Signup and view all the answers

What type of cells are primarily responsible for phagocytosis?

<p>Macrophages and certain white blood cells (C)</p> Signup and view all the answers

During which process can pinocytic vacuoles either remain unaltered or fuse with lysosomes?

<p>Pinocytosis (A)</p> Signup and view all the answers

What occurs during the process of cellular defaecation?

<p>Undigestible materials are expelled from the cell. (A)</p> Signup and view all the answers

Flashcards

Diffusion

The movement of molecules from a region of higher concentration to a region of lower concentration, driven by the concentration gradient.

Simple Diffusion

Diffusion that occurs directly across the cell membrane without the help of any membrane proteins.

Facilitated Diffusion

Diffusion that requires the assistance of membrane proteins, such as carrier proteins or channel proteins.

Osmosis

The movement of water across a semi-permeable membrane from a region of higher water concentration (lower solute concentration) to a region of lower water concentration (higher solute concentration).

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Active Transport

The net movement of a substance across a membrane against its concentration gradient, requiring energy input.

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Primary Active Transport

Active transport that directly uses energy from ATP hydrolysis.

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Secondary Active Transport

Active transport that uses the electrochemical gradient created by primary active transport to move other substances.

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Endocytosis

The process by which cells engulf large particles or fluids by forming vesicles.

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Fick's law of diffusion

The net rate of diffusion is proportional to the concentration gradient, surface area, and permeability, and inversely proportional to the thickness of the membrane.

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Selective Permeability of Cell Membrane

Cell membranes are selectively permeable, meaning they allow some substances to pass through while blocking others.

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Concentration Gradient

The difference in concentration of a substance across a membrane, driving diffusion from higher to lower concentrations.

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Donnan effect

A special case of diffusion where the presence of a non-diffusible ion on one side of the membrane affects the distribution of diffusible ions.

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Nondiffusible Ions

Proteins and other organic anions that cannot cross the cell membrane.

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Lipid Soluble Molecules

Lipophilic molecules like oxygen and nitrogen that easily dissolve in the lipid bilayer and cross cell membranes.

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Filtration

The movement of fluid across a membrane due to a pressure difference. It is directly proportional to the pressure gradient and the filtration coefficient.

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Filtration Coefficient (Kf)

The area of the membrane multiplied by its permeability to water. It represents the ease with which fluid can pass through the membrane.

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Solvent Drag

The tendency of solvent to drag along solutes as it moves across a membrane due to pressure difference.

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Sodium-Potassium Pump

A protein pump in the cell membrane that uses ATP to move sodium out of the cell and potassium into the cell, creating an electrochemical gradient.

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H+ - K+ ATPase

A protein pump that uses ATP to pump hydrogen ions (H+) out of the cell, found in acid-secreting cells like those in the stomach.

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Ca2+ - ATPase

A protein pump that uses ATP to pump calcium ions (Ca2+) out of the cytoplasm into the endoplasmic reticulum, important for muscle relaxation.

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V-ATPases

Proton pumps found in organelles like lysosomes and Golgi, responsible for pumping protons (H+) out of the cytoplasm into these compartments.

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F-ATPases

Proton pumps located in mitochondria, responsible for pumping protons from the matrix into the intermembrane space, establishing the proton gradient for ATP synthesis.

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SGLT (Sodium-Glucose Linked Transporter)

A co-transporter protein that facilitates the simultaneous movement of glucose and sodium ions into intestinal and renal cells.

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Sodium-Dependent Calcium Transport

A type of secondary active transport that uses the sodium gradient to move calcium out of cardiac and smooth muscle cells, contributing to muscle relaxation.

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Phagocytosis

A type of endocytosis where the cell takes in large particles, such as bacteria or cellular debris.

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Nonionic Diffusion

Diffusion of weak acids and bases in their undissociated (nonionic) form. This form allows them to cross cell membranes more easily, while the ionic form struggles.

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Osmotic Pressure

The pressure needed to prevent the movement of water across a semi-permeable membrane when there's a difference in solute concentration. It's a measure of how strongly a solution draws water.

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Oncotic Pressure

The osmotic pressure exerted specifically by plasma proteins. These large molecules can't easily cross the membrane, creating a drawing force for water.

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Hypertonic Solution

A solution with a higher concentration of solutes compared to plasma. A hypertonic solution can cause cells to shrink as water moves out.

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Hypotonic Solution

A solution with a lower concentration of solutes compared to plasma. A hypotonic solution can cause cells to swell as water moves in.

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Ultrafiltration

Filtration across the capillary wall. It's a specialized type of filtration where even colloids like proteins are retained.

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What is phagocytosis?

Process where cells engulf large particles like bacteria, dead tissue, or visible debris.

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Which cells are phagocytic?

Specialized cells like macrophages and some white blood cells are able to perform phagocytosis.

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How does phagocytosis work?

The cell membrane surrounds the particle, forming a vacuole that fuses with lysosomes for digestion.

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What is pinocytosis?

Process where cells take in large dissolved molecules like proteins.

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How does pinocytosis work?

The cell membrane invaginates, forming a vesicle that carries the molecules inside.

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What is exocytosis?

Process where cells release substances like proteins or large molecules to the outside.

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How does exocytosis work?

Secretory granules or vesicles containing the substances fuse with the cell membrane, releasing their contents.

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What is needed for exocytosis?

Exocytosis requires calcium ions (Ca2+) and energy, and special docking proteins.

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Study Notes

Chapter 3: Membrane Physiology

  • Transport across cell membranes is crucial for multicellular organisms
  • The internal environment (ECF) composition differs from intracellular fluid (ICF)
  • Differences are due to the cell membrane, which regulates the exchange of materials
  • Transport occurs via passive and active mechanisms

Passive Transport Mechanisms

  • Diffusion:

    • Simple diffusion: Molecules move down their concentration gradient
    • Facilitated diffusion: Carrier proteins aid movement down the gradient
    • Nonionic diffusion: Movement of uncharged molecules
  • Osmosis: Movement of water across a selectively permeable membrane from an area of higher water concentration to an area of lower concentration

  • Filtration: Movement of small molecules through a membrane due to pressure differences

Active Transport Mechanisms

  • Primary active transport: Uses energy (ATP) directly to move molecules against their concentration gradient, exemplified by the sodium-potassium pump.
    • The sodium-potassium pump extrudes sodium (3 Na+) and brings in potassium (2 K+)
  • Secondary active transport: Uses the electrochemical gradient of one molecule (often Na+) to move another molecule against its gradient.
    • Examples include glucose transport
  • Endocytosis: Cellular uptake of materials by engulfing them in vesicles
    • Types include phagocytosis (engulfing large particles) and pinocytosis (engulfing fluids or dissolved substances)
  • Exocytosis: Cellular release of materials by fusing vesicles with the cell membrane

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