1.3 Cell Membrane Transport Overview

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Questions and Answers

Which substance is found in higher concentration in extracellular fluid compared to intracellular fluid?

  • Phosphates
  • Sodium (correct)
  • Amino acids
  • Potassium

What is the primary structural component of the cell membrane?

  • A single layer of proteins
  • A lipid bilayer (correct)
  • A lipid monolayer
  • A carbohydrate matrix

What type of substances can readily diffuse directly through the lipid bilayer of a cell membrane?

  • Large polar molecules
  • Lipid-soluble substances (correct)
  • Charged ions
  • Hydrophilic molecules

What is the role of carrier proteins in cell membrane transport?

<p>To bind with molecules and facilitate movement through conformational changes (D)</p> Signup and view all the answers

Which of the following best describes active transport?

<p>Movement of ions against the concentration gradient, requiring additional energy (A)</p> Signup and view all the answers

What is the underlying principle of the constant motion of molecules?

<p>Heat or Entropy (D)</p> Signup and view all the answers

What is the result of increasing temperature on the rate of diffusion?

<p>The rate of diffusion increases. (D)</p> Signup and view all the answers

Which of the following describes the characteristic of the cell's lipid bilayer?

<p>Polar exterior, non-polar interior (D)</p> Signup and view all the answers

What is the primary function of sodium in the co-transport mechanism with glucose and amino acids?

<p>To utilize energy to transport other substances against their gradient (C)</p> Signup and view all the answers

In which part of the body does the active transport of sodium ions primarily facilitate absorption?

<p>Epithelial cells of the intestines and renal tubules (D)</p> Signup and view all the answers

What occurs when sodium ions are actively transported into the extracellular fluid?

<p>It leads to the osmosis of water due to high sodium concentration (A)</p> Signup and view all the answers

What role do transport proteins play in sodium-glucose co-transport?

<p>They require glucose binding to transport sodium across the membrane (B)</p> Signup and view all the answers

How does the brush border on the luminal surfaces of the cell contribute to sodium and water transport?

<p>It is permeable to both sodium ions and water, facilitating diffusion (C)</p> Signup and view all the answers

What is the primary mechanism by which lipid-soluble substances traverse a cell membrane?

<p>Directly through the lipid bilayer. (B)</p> Signup and view all the answers

What characteristic of aquaporins allows for rapid passage of water through the cell membrane?

<p>They have a narrow pore that permits water to pass single file. (A)</p> Signup and view all the answers

How do protein channels differ from pores in cell membranes?

<p>Protein channels can be gated, whereas pores are always open. (C)</p> Signup and view all the answers

Which factor does NOT affect molecule diffusion through a lipid bilayer?

<p>The presence of carrier proteins. (B)</p> Signup and view all the answers

What mechanism do voltage-gated channels in a cell membrane use to control ion permeability?

<p>Changes in electrical potential across the membrane. (A)</p> Signup and view all the answers

What is the role of carbonyl oxygens within a potassium channel?

<p>They dehydrate potassium ions, allowing them to pass through the channel. (A)</p> Signup and view all the answers

In facilitated diffusion, what limits the maximum rate of substance transport?

<p>The rate at which carrier proteins can change states. (B)</p> Signup and view all the answers

Which of the following is TRUE about the movement of molecules during simple diffusion?

<p>Molecular movement is constant, even at equilibrium. (A)</p> Signup and view all the answers

What happens when a strong electrical gradient opposes the concentration gradient across a cell membrane?

<p>An equilibrium will be reached, balancing both gradients. (A)</p> Signup and view all the answers

What is the basis of osmotic pressure?

<p>The number of particles in a solution, regardless of their mass. (D)</p> Signup and view all the answers

How does pressure affect net diffusion across a selectively permeable membrane?

<p>Molecules move from areas of higher pressure to lower pressure. (B)</p> Signup and view all the answers

Which of these best describes the role of acetylcholine in ligand-gated channels?

<p>It alters the shape of the receptor and opens a negatively charged pore. (B)</p> Signup and view all the answers

Why is water, a lipid-insoluble molecule, able to move into the cell?

<p>It moves through protein channels called aquaporins. (C)</p> Signup and view all the answers

What distinguishes a ligand-gated channel from a voltage-gated channel?

<p>Ligand-gated channels are regulated by chemical substances, whereas voltage-gated channels are controlled by electric signals. (B)</p> Signup and view all the answers

In what way do potassium channels exhibit selectivity for potassium ions over sodium ions?

<p>Their carbonyl oxygens are too far apart to dehydrate the smaller hydrated sodium ions. (D)</p> Signup and view all the answers

What is the primary function of the sodium-potassium pump?

<p>To maintain concentration differences of sodium and potassium across the cell membrane (B)</p> Signup and view all the answers

Which statement accurately describes osmolality?

<p>It measures the total number of particles in a solution per kilogram. (B)</p> Signup and view all the answers

What happens to sodium ions during the operation of the sodium-potassium pump?

<p>They are expelled outside the cell in a ratio of three sodium to two potassium. (B)</p> Signup and view all the answers

What is the primary energy source for primary active transport?

<p>The breakdown of ATP and high-energy phosphate compounds (B)</p> Signup and view all the answers

What role does calcium play in muscle function?

<p>Calcium is transported into the sarcoplasmic reticulum for muscle contraction. (B)</p> Signup and view all the answers

How is secondary active transport different from primary active transport?

<p>Secondary active transport relies on ionic gradients established by primary transport. (A)</p> Signup and view all the answers

What is the intracellular concentration of potassium?

<p>140 mM (C)</p> Signup and view all the answers

Which of the following correctly identifies the condition of the intracellular environment?

<p>It is rich in negatively charged proteins. (D)</p> Signup and view all the answers

What effect does the sodium-potassium pump have on cell volume?

<p>It controls cell volume by expelling sodium and bringing in potassium. (A)</p> Signup and view all the answers

What condition can prompt the activation of the sodium-potassium pump?

<p>When the cell begins to swell. (B)</p> Signup and view all the answers

Which of the following statements about osmosis is true?

<p>It depends on the number of solute particles in a solution. (D)</p> Signup and view all the answers

In which organ is the primary active transport of hydrogen especially significant?

<p>Kidney (D)</p> Signup and view all the answers

What happens to the sodium concentration when sodium is transported out of the cell?

<p>A sodium gradient is created across the cellular membrane. (A)</p> Signup and view all the answers

What is one of the key roles of ATP in cellular processes?

<p>To provide energy for active transport mechanisms (C)</p> Signup and view all the answers

Flashcards

Intracellular & Extracellular Fluid Concentration Differences

The difference in concentration of substances between the interior and exterior of a cell.

Lipid Bilayer

A double layer of lipids (fats) that forms the outer boundary of a cell, acting as a selective barrier.

Diffusion

The process where molecules move from areas of high concentration to areas of low concentration, following the concentration gradient.

Facilitated Diffusion

Type of diffusion where a carrier protein helps a molecule cross the cell membrane.

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Active Transport

The process of molecules moving against their concentration gradient, requiring energy.

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Sodium-Potassium Pump

A transporter protein that moves sodium (Na+) ions out of the cell and potassium (K+) ions into the cell. Requires energy (ATP).

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Lipid-Soluble

The state where a molecule can easily pass through the cell membrane because it is similar in structure to the membrane's lipid content.

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Transport Proteins

Proteins embedded within the cell membrane that assist in the movement of various molecules across the membrane.

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Secondary Active Transport

A process where the movement of one substance down its concentration gradient provides energy for another substance to move against its gradient.

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Sodium-Glucose Co-transport

A type of secondary active transport where the movement of sodium ions down their concentration gradient powers the transport of glucose into the cell.

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Transcellular Transport

A mechanism of moving substances across a sheet of cells, involving transport through the cell membrane on one side and either simple or facilitated diffusion on the other.

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Sodium-Driven Water Transport

The active transport of sodium ions across the cell membrane creates a high concentration gradient, causing water to move by osmosis.

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Sodium Transport and Water Movement

The active transport of sodium ions across the cell membrane leads to the simultaneous movement of water, due to the osmotic gradient created.

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Simple Diffusion

Movement of molecules across a cell membrane without the help of carrier proteins. It can occur through the lipid bilayer (for lipid-soluble substances) or through water-filled channels (for some water-soluble substances).

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Lipid Solubility and Diffusion

The rate of diffusion is directly proportional to the molecule's lipid solubility. This means lipid-soluble molecules move more easily across the membrane.

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Aquaporins

Water-filled channels in cell membranes that specifically transport water. These channels are known as aquaporins.

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Pores

These are open tubules formed by integral membrane proteins, providing a pathway for molecules to pass through the cell membrane.

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Protein Channels

These are specialized proteins that allow only specific molecules to pass through the cell membrane. They are highly selective and can be open or closed by gates.

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Ligand-gated Channels

Protein channels regulated by the binding of a specific chemical substance, or ligand, to the channel.

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Voltage-gated Channels

Protein channels regulated by changes in the electrical potential across the cell membrane.

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Concentration Gradient

The movement of molecules across a membrane due to a difference in concentration. Molecules move from an area of high concentration to low concentration. (Think of a drop of ink spreading in water.)

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Electrical Gradient

The movement of ions across a membrane due to a difference in electrical potential. Opposites attract, so positive ions move to areas with a negative charge, and vice versa.

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Electrochemical Equilibrium

This is a state of equilibrium. The concentration gradient and electrical gradient balance each other out and there is no net movement of ions across the membrane.

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Osmotic Pressure

The pressure required to stop the movement of water across a selectively permeable membrane. This pressure is created by the concentration of solute particles on one side of the membrane.

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Osmosis

This is the movement of water across a selectively permeable membrane from a region of high water concentration to a region of low water concentration.

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Endocytosis

The process by which a cell takes in molecules from the surrounding environment. This is a type of active transport that requires energy.

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Exocytosis

The process by which a cell releases molecules to the surrounding environment. This is a type of active transport that requires energy.

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Osmolarity

The concentration of a solution expressed as the number of particles per unit volume, often measured in osmoles per liter (Osm/L).

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Osmolality

The concentration of a solution expressed as the number of particles per unit mass of solvent, often measured in osmoles per kilogram (Osm/kg).

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Primary Active Transport

Active transport that directly utilizes energy released from ATP hydrolysis.

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Electrogenic Nature of the Sodium-Potassium Pump

A process where the sodium-potassium pump moves three sodium ions out of the cell for every two potassium ions pumped in, contributing to the membrane potential.

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Membrane Potential

The difference in electrical potential across a cell membrane, typically negative inside the cell due to the active transport of ions.

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Role of Sodium-Potassium Pump in Cell Volume Regulation

A process that controls cell volume by regulating the movement of ions and water across the cell membrane.

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Cotransport

The transport of molecules or ions across a membrane in the same direction, driven by the concentration gradient of one of the substances.

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Countertransport

The transport of molecules or ions across a membrane in opposite directions, driven by the concentration gradient of one of the substances.

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Calcium Transport Systems

The process of maintaining low intracellular calcium concentrations through active transport, essential for muscle function.

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Hydrogen Ion Transport

The active transport of hydrogen ions, important for maintaining acid-base balance in the stomach and kidneys.

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Sodium Gradient Driven Secondary Active Transport

Secondary active transport that utilizes the concentration gradient of sodium ions to drive the movement of other substances across the membrane.

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Study Notes

Cell Membrane Transport

  • Fluid Composition Differences: Intracellular and extracellular fluids have vastly different ion concentrations.
    • Extracellular fluid: High sodium, high chloride.
    • Intracellular fluid: High potassium, high phosphates, high amino acids.
  • Cell Membrane Structure: The membrane is a lipid bilayer.
    • Polar, hydrophilic exterior.
    • Nonpolar, lipophilic interior, impermeable to polar substances.
    • Lipid-soluble substances diffuse directly through the lipid layer.
    • Proteins (integral) act as transport channels or carriers.
  • Transport Mechanisms:
    • Diffusion: Random movement of molecules.
      • Simple diffusion: Passive movement through membrane openings or intermolecular spaces. Facilitated diffusion involves carrier proteins.
      • Lipid solubility: Affects diffusion rate through the lipid bilayer. High lipid solubility, like oxygen, leads to rapid diffusion.
      • Protein channels: Allow passage of water-insoluble, charged molecules.
        • Aquaporins: Specialized channels for water, enabling rapid water movement.
        • Pores: Always open, selective based on pore diameter and charge.
        • Protein Channels: Selectively permeable to certain substances; may be open or closed gates regulated by chemicals (ligand-gated) or electrical signals (voltage-gated).
    • Active Transport: Movement against a concentration gradient. Requires energy (ATP).
      • Carrier proteins are essential for active transport.
      • Primary active transport: Direct use of ATP.
      • Secondary active transport: Relies on the stored energy of another ion gradient created by primary active transport.
  • Sodium-Potassium Pump: A primary active transport mechanism.
    • Pumps 3 sodium ions out of and 2 potassium ions into the cell per ATP molecule.
    • Creates a concentration gradient for sodium and potassium and a negative intracellular electrical potential.
    • Crucial for maintaining cell volume, nerve and muscle function.
  • Calcium Transport:
    • Maintained at extremely low intracellular concentrations.
    • Active transport pumps calcium outside the cell or into the sarcoplasmic reticulum and mitochondria for muscle function.
  • Hydrogen Ion Transport:
    • Important in stomach parietal cells and renal intercalated cells for acid secretion and hydrogen elimination.
  • Secondary Active Transport (Co-transport/Counter-transport):
    • Co-transport: Sodium moves down its gradient, pulling another substance (like glucose) into the cell.
    • Counter-transport: Sodium moves down its gradient, while another substance (like calcium or hydrogen) moves in the opposite direction.
  • Transcellular Transport: Substances move through a sheet of cells, across the cell membrane on one side, then across the other side.
  • Osmosis: Water movement across a membrane.
    • Affected by concentration differences (osmotic pressure), electrical potential, and pressure across the membrane.
    • Osmolarity & Osmolality: Measures of solute concentration.
  • Factors Affecting Net Diffusion: Concentration difference, electrical potential, and pressure difference across a membrane.

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