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Questions and Answers
Which substance is found in higher concentration in extracellular fluid compared to intracellular fluid?
Which substance is found in higher concentration in extracellular fluid compared to intracellular fluid?
- Phosphates
- Sodium (correct)
- Amino acids
- Potassium
What is the primary structural component of the cell membrane?
What is the primary structural component of the cell membrane?
- A single layer of proteins
- A lipid bilayer (correct)
- A lipid monolayer
- A carbohydrate matrix
What type of substances can readily diffuse directly through the lipid bilayer of a cell membrane?
What type of substances can readily diffuse directly through the lipid bilayer of a cell membrane?
- Large polar molecules
- Lipid-soluble substances (correct)
- Charged ions
- Hydrophilic molecules
What is the role of carrier proteins in cell membrane transport?
What is the role of carrier proteins in cell membrane transport?
Which of the following best describes active transport?
Which of the following best describes active transport?
What is the underlying principle of the constant motion of molecules?
What is the underlying principle of the constant motion of molecules?
What is the result of increasing temperature on the rate of diffusion?
What is the result of increasing temperature on the rate of diffusion?
Which of the following describes the characteristic of the cell's lipid bilayer?
Which of the following describes the characteristic of the cell's lipid bilayer?
What is the primary function of sodium in the co-transport mechanism with glucose and amino acids?
What is the primary function of sodium in the co-transport mechanism with glucose and amino acids?
In which part of the body does the active transport of sodium ions primarily facilitate absorption?
In which part of the body does the active transport of sodium ions primarily facilitate absorption?
What occurs when sodium ions are actively transported into the extracellular fluid?
What occurs when sodium ions are actively transported into the extracellular fluid?
What role do transport proteins play in sodium-glucose co-transport?
What role do transport proteins play in sodium-glucose co-transport?
How does the brush border on the luminal surfaces of the cell contribute to sodium and water transport?
How does the brush border on the luminal surfaces of the cell contribute to sodium and water transport?
What is the primary mechanism by which lipid-soluble substances traverse a cell membrane?
What is the primary mechanism by which lipid-soluble substances traverse a cell membrane?
What characteristic of aquaporins allows for rapid passage of water through the cell membrane?
What characteristic of aquaporins allows for rapid passage of water through the cell membrane?
How do protein channels differ from pores in cell membranes?
How do protein channels differ from pores in cell membranes?
Which factor does NOT affect molecule diffusion through a lipid bilayer?
Which factor does NOT affect molecule diffusion through a lipid bilayer?
What mechanism do voltage-gated channels in a cell membrane use to control ion permeability?
What mechanism do voltage-gated channels in a cell membrane use to control ion permeability?
What is the role of carbonyl oxygens within a potassium channel?
What is the role of carbonyl oxygens within a potassium channel?
In facilitated diffusion, what limits the maximum rate of substance transport?
In facilitated diffusion, what limits the maximum rate of substance transport?
Which of the following is TRUE about the movement of molecules during simple diffusion?
Which of the following is TRUE about the movement of molecules during simple diffusion?
What happens when a strong electrical gradient opposes the concentration gradient across a cell membrane?
What happens when a strong electrical gradient opposes the concentration gradient across a cell membrane?
What is the basis of osmotic pressure?
What is the basis of osmotic pressure?
How does pressure affect net diffusion across a selectively permeable membrane?
How does pressure affect net diffusion across a selectively permeable membrane?
Which of these best describes the role of acetylcholine in ligand-gated channels?
Which of these best describes the role of acetylcholine in ligand-gated channels?
Why is water, a lipid-insoluble molecule, able to move into the cell?
Why is water, a lipid-insoluble molecule, able to move into the cell?
What distinguishes a ligand-gated channel from a voltage-gated channel?
What distinguishes a ligand-gated channel from a voltage-gated channel?
In what way do potassium channels exhibit selectivity for potassium ions over sodium ions?
In what way do potassium channels exhibit selectivity for potassium ions over sodium ions?
What is the primary function of the sodium-potassium pump?
What is the primary function of the sodium-potassium pump?
Which statement accurately describes osmolality?
Which statement accurately describes osmolality?
What happens to sodium ions during the operation of the sodium-potassium pump?
What happens to sodium ions during the operation of the sodium-potassium pump?
What is the primary energy source for primary active transport?
What is the primary energy source for primary active transport?
What role does calcium play in muscle function?
What role does calcium play in muscle function?
How is secondary active transport different from primary active transport?
How is secondary active transport different from primary active transport?
What is the intracellular concentration of potassium?
What is the intracellular concentration of potassium?
Which of the following correctly identifies the condition of the intracellular environment?
Which of the following correctly identifies the condition of the intracellular environment?
What effect does the sodium-potassium pump have on cell volume?
What effect does the sodium-potassium pump have on cell volume?
What condition can prompt the activation of the sodium-potassium pump?
What condition can prompt the activation of the sodium-potassium pump?
Which of the following statements about osmosis is true?
Which of the following statements about osmosis is true?
In which organ is the primary active transport of hydrogen especially significant?
In which organ is the primary active transport of hydrogen especially significant?
What happens to the sodium concentration when sodium is transported out of the cell?
What happens to the sodium concentration when sodium is transported out of the cell?
What is one of the key roles of ATP in cellular processes?
What is one of the key roles of ATP in cellular processes?
Flashcards
Intracellular & Extracellular Fluid Concentration Differences
Intracellular & Extracellular Fluid Concentration Differences
The difference in concentration of substances between the interior and exterior of a cell.
Lipid Bilayer
Lipid Bilayer
A double layer of lipids (fats) that forms the outer boundary of a cell, acting as a selective barrier.
Diffusion
Diffusion
The process where molecules move from areas of high concentration to areas of low concentration, following the concentration gradient.
Facilitated Diffusion
Facilitated Diffusion
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Active Transport
Active Transport
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Sodium-Potassium Pump
Sodium-Potassium Pump
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Lipid-Soluble
Lipid-Soluble
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Transport Proteins
Transport Proteins
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Secondary Active Transport
Secondary Active Transport
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Sodium-Glucose Co-transport
Sodium-Glucose Co-transport
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Transcellular Transport
Transcellular Transport
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Sodium-Driven Water Transport
Sodium-Driven Water Transport
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Sodium Transport and Water Movement
Sodium Transport and Water Movement
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Simple Diffusion
Simple Diffusion
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Lipid Solubility and Diffusion
Lipid Solubility and Diffusion
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Aquaporins
Aquaporins
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Pores
Pores
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Protein Channels
Protein Channels
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Ligand-gated Channels
Ligand-gated Channels
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Voltage-gated Channels
Voltage-gated Channels
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Concentration Gradient
Concentration Gradient
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Electrical Gradient
Electrical Gradient
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Electrochemical Equilibrium
Electrochemical Equilibrium
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Osmotic Pressure
Osmotic Pressure
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Osmosis
Osmosis
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Endocytosis
Endocytosis
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Exocytosis
Exocytosis
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Osmolarity
Osmolarity
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Osmolality
Osmolality
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Primary Active Transport
Primary Active Transport
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Electrogenic Nature of the Sodium-Potassium Pump
Electrogenic Nature of the Sodium-Potassium Pump
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Membrane Potential
Membrane Potential
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Role of Sodium-Potassium Pump in Cell Volume Regulation
Role of Sodium-Potassium Pump in Cell Volume Regulation
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Cotransport
Cotransport
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Countertransport
Countertransport
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Calcium Transport Systems
Calcium Transport Systems
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Hydrogen Ion Transport
Hydrogen Ion Transport
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Sodium Gradient Driven Secondary Active Transport
Sodium Gradient Driven Secondary Active Transport
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Study Notes
Cell Membrane Transport
- Fluid Composition Differences: Intracellular and extracellular fluids have vastly different ion concentrations.
- Extracellular fluid: High sodium, high chloride.
- Intracellular fluid: High potassium, high phosphates, high amino acids.
- Cell Membrane Structure: The membrane is a lipid bilayer.
- Polar, hydrophilic exterior.
- Nonpolar, lipophilic interior, impermeable to polar substances.
- Lipid-soluble substances diffuse directly through the lipid layer.
- Proteins (integral) act as transport channels or carriers.
- Transport Mechanisms:
- Diffusion: Random movement of molecules.
- Simple diffusion: Passive movement through membrane openings or intermolecular spaces. Facilitated diffusion involves carrier proteins.
- Lipid solubility: Affects diffusion rate through the lipid bilayer. High lipid solubility, like oxygen, leads to rapid diffusion.
- Protein channels: Allow passage of water-insoluble, charged molecules.
- Aquaporins: Specialized channels for water, enabling rapid water movement.
- Pores: Always open, selective based on pore diameter and charge.
- Protein Channels: Selectively permeable to certain substances; may be open or closed gates regulated by chemicals (ligand-gated) or electrical signals (voltage-gated).
- Active Transport: Movement against a concentration gradient. Requires energy (ATP).
- Carrier proteins are essential for active transport.
- Primary active transport: Direct use of ATP.
- Secondary active transport: Relies on the stored energy of another ion gradient created by primary active transport.
- Diffusion: Random movement of molecules.
- Sodium-Potassium Pump: A primary active transport mechanism.
- Pumps 3 sodium ions out of and 2 potassium ions into the cell per ATP molecule.
- Creates a concentration gradient for sodium and potassium and a negative intracellular electrical potential.
- Crucial for maintaining cell volume, nerve and muscle function.
- Calcium Transport:
- Maintained at extremely low intracellular concentrations.
- Active transport pumps calcium outside the cell or into the sarcoplasmic reticulum and mitochondria for muscle function.
- Hydrogen Ion Transport:
- Important in stomach parietal cells and renal intercalated cells for acid secretion and hydrogen elimination.
- Secondary Active Transport (Co-transport/Counter-transport):
- Co-transport: Sodium moves down its gradient, pulling another substance (like glucose) into the cell.
- Counter-transport: Sodium moves down its gradient, while another substance (like calcium or hydrogen) moves in the opposite direction.
- Transcellular Transport: Substances move through a sheet of cells, across the cell membrane on one side, then across the other side.
- Osmosis: Water movement across a membrane.
- Affected by concentration differences (osmotic pressure), electrical potential, and pressure across the membrane.
- Osmolarity & Osmolality: Measures of solute concentration.
- Factors Affecting Net Diffusion: Concentration difference, electrical potential, and pressure difference across a membrane.
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