Cell Membrane Structure and Drug Targets Quiz

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Which of the following is NOT a common drug target according to the text?

Receptors

Structural proteins (tubulin)

Enzymes

Nucleic acids (correct)

In the context of drug targeting, which type of bonds are mentioned as different from covalent bonds?

Disulfide bonds (correct)

Van der Waals forces

Ionic bonds

Hydrogen bonds

Where are proteins, the most common drug targets, mainly located according to the text?

Mitochondria

Cell membrane or cytoplasm (correct)

Endoplasmic reticulum

Cell nucleus

What does a drug target do when a drug binds to it according to the text?

Undergoes change in function Signup and view all the answers

What type of bonds are the strongest intermolecular bonding forces mentioned in the text?

Electrostatic or ionic bonds Signup and view all the answers

Which type of bond involves directional orbitals and has an optimum direction where the X-H bond points directly to the lone pair on Y?

Hydrogen bonds Signup and view all the answers

Which is an example of a good hydrogen bond donor according to the text?

Quaternary ammonium ion Signup and view all the answers

What type of drug-target interaction involves transient areas of high and low electron densities causing temporary dipoles?

Van der Waals interactions Signup and view all the answers

In what type of environment are ionic interactions stronger, according to the text?

Hydrophobic environment Signup and view all the answers

Which of the following is NOT an example of a good hydrogen bond acceptor based on the text?

Aromatic ring Signup and view all the answers

What happens to the strength of dipole-dipole interactions as the distance between molecules increases?

Decreases less rapidly than electrostatic interactions Signup and view all the answers

How do ion-dipole interactions compare to dipole-dipole interactions in terms of strength?

Ion-dipole interactions are stronger Signup and view all the answers

What is the primary characteristic of induced dipole interactions?

They involve one molecule inducing a dipole on another Signup and view all the answers

Which intermolecular force involves the interaction between aromatic rings?

Pi-stacking (π-π stacking) Signup and view all the answers

In what scenario would dipole-dipole interactions be detrimental to molecular orientation in a binding site?

When the drug's orientation is not beneficial due to incorrect binding group positions Signup and view all the answers

What is a distinguishing feature of Pi-stacking (π-π stacking) compared to other types of intermolecular forces?

It involves attractive interactions between aromatic rings Signup and view all the answers

What type of interactions are involved in Pi-stacking (π-π stacking)?

Quadrupole-quadrupole interactions and London dispersion forces Signup and view all the answers

What is necessary for desolvation to occur during drug-target interactions?

Energy penalty due to breaking bonds Signup and view all the answers

What contributes to the increase in entropy during drug-target interactions involving hydrophobic regions?

Formation of more structured water layers Signup and view all the answers

What type of bonds are most commonly formed between a drug and its target according to the text?

Electrostatic/ionic bonds Signup and view all the answers

Which type of bond involves an optimum direction where one bond points directly to the lone pair on another?

Hydrogen bond Signup and view all the answers

What do hydrophobic interactions in drug targeting specifically 'free up', leading to higher entropy?

Structured water molecules Signup and view all the answers