Cell Membrane Drug Transfer and Administration Routes Quiz

What are the two main processes of transfer of drugs across cell barriers?

What are the main features of lipid diffusion of drugs across membranes?

What are the main features of aqueous diffusion of drugs across membranes?

Which of the following is true about drug administration?

What does bioavailability (F) provide a quantitative measure of?

Which factor does not affect drug absorption?

How is bioavailability (F) calculated?

What does a bioavailability of 100% indicate?

In the equation for calculating bioavailability, what does AUC represent?

What does a lower oral bioavailability percentage indicate?

If the AUC for a drug given orally is 200 (mg/L) x h and the AUC for the same drug given intravenously is 300 (mg/L) x h, what is the bioavailability?

If a dose of a drug given orally yields an AUC of (50 mcg/ml)x min while the same dose given IV yields an AUC of 100 (mcg/ml) x min, what is the oral bioavailability?

Which process facilitates drug movement across membranes through intercellular pores?

What theory explains drug concentration in specific compartments depending on pH?

Which drug illustrates the ion trapping mechanism with a pKa of 3?

In which step of ion trapping does passive reabsorption of lipid-soluble, unionized drug molecules occur?

Which drug administration route involves absorption through the lungs?

What factor affecting drug absorption via the oral route is discussed in the text?

Which drug administration route involves absorption through the skin?

Which process involves the movement of drug molecules from an area of low concentration to an area of high concentration?

Which drug administration route involves absorption through the mucous membranes under the tongue?

Which drug administration route involves absorption through the rectum?

Which type of drug transport is based solely on molecular size and is passive and non-selective?

Which theory explains drug concentration in specific compartments depending on the difference between pH and pKa?

Which route of drug administration involves placing the drug under the tongue?

What is the most important site for passive drug absorption due to its high surface area and high blood flow?

Which factor may affect the process of absorption of drugs administered orally?

What does a delay in gastric emptying do to the rate and extent of drug absorption?

Which route of drug administration involves placing the drug between the cheek and gum?

What is the primary method of absorption for drugs administered through the sublingual route?

Which route of administration involves drug delivery to the intestine and is affected by gastric emptying?

What can delay in gastric emptying potentially do to the pH of the stomach and drug permeation behavior?

What does enteral administration of a drug involve?

Which route of administration bypasses the harsh gastrointestinal (GI) environment and avoids the first-pass effect?

What is the main site for drug absorption in the body?

What is a disadvantage of oral drug administration?

Which type of transport is mediated by a protein carrier, does not require energy, and is structurally selective for the drug?

What type of transport moves drugs against a concentration gradient and is driven by ATP hydrolysis?

What type of transport involves cell membrane engulfing of drugs and transportation into the cell by vesicle formation?

Which process is used to secrete substances out of the cell through vesicle formation?

What is the molecular weight range of drugs that can cross membranes by lipid diffusion?

Which type of transport is dependent on channel number, concentration gradient, water solubility, and molecular size of the drug?

What type of transport process is driven by ATP hydrolysis and can be primary or secondary?

Which type of transport involves the movement of fluids and solutes across cell barriers?

What type of transport involves the movement of drugs through gaps between cells?

Which type of transport is mediated by influx transporters increasing drug absorption and efflux transporters decreasing it?

What type of transport is used for substances too large to pass through the plasma cell membrane or transport proteins?

Which type of transport involves the movement of drugs across cells?

Which drug administration route is primarily suitable for lipophilic drugs and bypasses first-pass effect?

Which drug administration route may cause pain if the drug is irritating and is unsuitable for large volumes?

Which route of administration achieves systemic effects with immediate drug availability in systemic circulation, suitable for emergency situations?

Which drug administration route achieves local effect with locally high drug concentration and delayed systemic absorption?

Which route of administration is suitable for drugs with slow-release properties?

Which drug administration route achieves rapid, direct systemic absorption, bypassing first-pass effect and stomach acid destruction?

Which drug administration route is primarily suitable for local effects on the skin, but absorption can be variable and unsuitable for certain drugs?

Which route of administration achieves systemic effects primarily by lipid diffusion through the alveolar membrane, but may cause allergic reactions in some patients?

Which drug administration route is used to localize drug effects at specific sites?

Which route of administration is primarily used for moderate volumes and may affect certain lab tests?

Which drug administration route is primarily used for systemic or local effects, primarily by lipid diffusion, but may irritate the rectal mucosa?

Which route of administration is suitable for achieving local effects on the skin but may have variable absorption and be unsuitable for certain drugs?