Podcast
Questions and Answers
What is the half-life of radioactive caesium (137Cs) in years?
What is the half-life of radioactive caesium (137Cs) in years?
Which factor does not affect the absorption of substances in the GI tract?
Which factor does not affect the absorption of substances in the GI tract?
What is a characteristic of the skin that affects its absorption of substances?
What is a characteristic of the skin that affects its absorption of substances?
What is the similarity between Cs+ and another ion?
What is the similarity between Cs+ and another ion?
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In which part of the body does the dissolution of particles occur during absorption?
In which part of the body does the dissolution of particles occur during absorption?
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What is the significance of the Fukushima nuclear disaster in relation to the Chernobyl disaster?
What is the significance of the Fukushima nuclear disaster in relation to the Chernobyl disaster?
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What is the primary factor affecting the absorption of gases, vapors, and volatile liquids in the lungs?
What is the primary factor affecting the absorption of gases, vapors, and volatile liquids in the lungs?
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What is the primary factor determining the selective transport of ions through ion channels?
What is the primary factor determining the selective transport of ions through ion channels?
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What is the primary mechanism of absorption of calcium from the intestine to the blood?
What is the primary mechanism of absorption of calcium from the intestine to the blood?
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Why is lead absorbed through the same calcium transport channel?
Why is lead absorbed through the same calcium transport channel?
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What is the primary effect of lead poisoning on children's health?
What is the primary effect of lead poisoning on children's health?
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What is the recommended prevention method for chronic lead poisoning?
What is the recommended prevention method for chronic lead poisoning?
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What is the primary function of the iodide transport pump?
What is the primary function of the iodide transport pump?
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What is the environmental hazard associated with radioactive iodine isotope I-131?
What is the environmental hazard associated with radioactive iodine isotope I-131?
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What is the primary factor that determines the rate of passive diffusion across a cell membrane?
What is the primary factor that determines the rate of passive diffusion across a cell membrane?
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Which type of transport is characterized by being energy-independent and substrate-specific?
Which type of transport is characterized by being energy-independent and substrate-specific?
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What is the primary factor that influences the permeability of endothelium?
What is the primary factor that influences the permeability of endothelium?
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Which type of transport can enhance the transport of xenobiotics up to 50,000 folds?
Which type of transport can enhance the transport of xenobiotics up to 50,000 folds?
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What is the maximum size of molecules that can move through cell pores?
What is the maximum size of molecules that can move through cell pores?
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Which type of transport is characterized by being independent of or against the concentration gradient?
Which type of transport is characterized by being independent of or against the concentration gradient?
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What is the primary function of the P-glycoprotein pump in the context of xenobiotics?
What is the primary function of the P-glycoprotein pump in the context of xenobiotics?
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What is the primary factor that determines the rate of blood flow to organs in the distribution phase of toxicokinetics?
What is the primary factor that determines the rate of blood flow to organs in the distribution phase of toxicokinetics?
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Which of the following tissues is considered highly perfused and more vulnerable to toxic effects?
Which of the following tissues is considered highly perfused and more vulnerable to toxic effects?
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What is the effect of a 100-fold increase in free pharmacologically active concentration at the site of action?
What is the effect of a 100-fold increase in free pharmacologically active concentration at the site of action?
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Which of the following barriers can affect the distribution of xenobiotics to target tissues?
Which of the following barriers can affect the distribution of xenobiotics to target tissues?
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What is the primary reason why the same dose of a xenobiotic can cause toxicity by one route but not another?
What is the primary reason why the same dose of a xenobiotic can cause toxicity by one route but not another?
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What percentage of molecules are typically bound to plasma proteins or RBCs in blood?
What percentage of molecules are typically bound to plasma proteins or RBCs in blood?
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Which of the following factors does not affect the extent of distribution of a xenobiotic?
Which of the following factors does not affect the extent of distribution of a xenobiotic?
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What is the primary mechanism by which water-soluble toxicants with a molecular weight of less than 70,000 are excreted through the kidney?
What is the primary mechanism by which water-soluble toxicants with a molecular weight of less than 70,000 are excreted through the kidney?
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What is the primary function of the liver in the elimination of toxicants?
What is the primary function of the liver in the elimination of toxicants?
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What is the primary route of excretion for gases and volatile liquids?
What is the primary route of excretion for gases and volatile liquids?
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What type of transport is involved in the excretion of conjugates with high molecular weight into bile?
What type of transport is involved in the excretion of conjugates with high molecular weight into bile?
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What is the primary reason why mother's milk is an important elimination route for toxicants?
What is the primary reason why mother's milk is an important elimination route for toxicants?
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What type of toxicants are more likely to be reabsorbed and cause systematic toxicity?
What type of toxicants are more likely to be reabsorbed and cause systematic toxicity?
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What is the primary mechanism by which toxicants are excreted from the GIT?
What is the primary mechanism by which toxicants are excreted from the GIT?
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What is the role of the kidney in the elimination of toxicants?
What is the role of the kidney in the elimination of toxicants?
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What is the primary function of biliary secretion in the elimination of toxicants?
What is the primary function of biliary secretion in the elimination of toxicants?
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What is the significance of sweat, saliva, and mother's milk as elimination routes for toxicants?
What is the significance of sweat, saliva, and mother's milk as elimination routes for toxicants?
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Study Notes
Radioactive Contamination
- Radioactive caesium levels are high enough to cause concern in areas of northern Japan 30-50 km from the plant.
- Fukushima releases are of the same order of magnitude as Chernobyl disaster in 1986.
Factors Affecting Absorption
- Determinants of passive transfer: lipid solubility, pH, surface area, concentration gradient, blood flow, and dissolution in the aqueous medium.
- GI absorption: disintegration of dosage form, dissolution of particles, chemical stability, motility, and mixing in the GI tract, and presence and type of food.
- Lungs absorption: large surface area, thin barrier, high blood flow, and rapid absorption for gases, vapors, and volatile liquids.
- Skin absorption: crossing several cell layers to reach blood vessels.
Absorption of Inorganic Ions
- Ion transport channels: selective preference for transporting certain ions, size and ionic charge determine selective transport.
- Cation transport channels: selective channels for transcellular transport of positively charged ions (e.g., calcium, lead).
- Anion transport channels: transport of negative charged ions (e.g., iodide).
Lead as an Environmental Hazard
- Environmental sources: leaded paints, auto exhaust, and pica in young children.
- Lead causes neurologic damage in children: IQ reduction, mild retardation, hyperactivity, and behavioral disorders.
- Prevention of chronic lead poisoning: calcium supplements, diet with milk, high protein intake, and adequate vitamin D.
Cell Membrane and Transport
- Cell membrane: lipid solubility, pH, and surface area affect permeability.
- Endothelium: size, shape, and charge of chemical affect permeability.
- Passive transport: no energy source required, uncharged molecules diffuse along concentration gradient, and lipophilic chemicals diffuse through the lipid bilayer.
- Facilitated transport: energy-independent, may enhance transport up to 50,000 folds, and substrate-specific.
- Active transport: independent of or against concentration gradient, requires energy, and substrate-specific.
Distribution
- Second phase of toxicokinetic process: defines where in the body a xenobiotic will go after absorption.
- Factors affecting distribution: size, molecular weight, lipid solubility, plasma protein or RBC binding, and tissue binding.
- Blood flow to target tissue is affected by internal membrane barriers and sequestration in non-target tissues.
Elimination Routes
- Kidney: major route, including filtration and reabsorption process.
- Liver: changes lipid soluble to more water soluble molecule for excretion in the kidney.
- Biliary secretion: active transport.
- Lung: exhalation of gases and volatile liquids by diffusion.
- Mother's milk: important for transfer to baby and transfer from animals to humans.
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Description
Test your understanding of cell membrane structure and function, including passive and active transport mechanisms, permeability, and factors affecting the transfer of molecules across membranes. Learn about the role of lipid solubility, pH, and concentration gradients in determining transport.
