Cell Injury

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Questions and Answers

Which of the following is a reversible response to cell injury?

  • Necrosis
  • Atrophy (correct)
  • Apoptosis
  • Hypertrophy

Which of the following is a physiological cause of hyperplasia?

  • Inadequate nutrition
  • Excessive hormonal/growth factor
  • Decreased workload (correct)
  • Loss of innervation

What is the main difference between necrosis and apoptosis?

  • Necrosis is a physiological response, while apoptosis is pathological
  • Necrosis is characterized by an increase in cell size, while apoptosis is characterized by a decrease in cell size
  • Necrosis is reversible, while apoptosis is irreversible
  • Necrosis involves cell death, while apoptosis is a form of cell adaptation (correct)

Which type of necrosis is characterized by the transformation of solid tissue into a liquid mass and complete digestion of dead cells?

<p>Liquefactive necrosis (D)</p> Signup and view all the answers

Which type of necrosis is characterized by a distinctive cheesy, crumbly, white gross appearance and is commonly associated with tuberculous infection?

<p>Caseous necrosis (B)</p> Signup and view all the answers

Which type of necrosis is characterized by the preservation of cell shape and organ structure, with disappearance of nuclei?

<p>Coagulative necrosis (C)</p> Signup and view all the answers

Which type of necrosis is associated with necrotic damage to blood vessel walls and often occurs in the context of vasculitis?

<p>Fibrinoid necrosis (B)</p> Signup and view all the answers

Which of the following is an example of metaplasia?

<p>Cigarette smoking causing respiratory epithelium to change to stratified squamous (A)</p> Signup and view all the answers

Which of the following is a cause of cell injury?

<p>Decrease in perfusion (D)</p> Signup and view all the answers

Which of the following is a consequence of irreversible cellular injury?

<p>Marked mitochondrial changes (D)</p> Signup and view all the answers

What is the role of free radicals in membrane damage?

<p>Free radicals are unstable molecules that activate enzymes (A)</p> Signup and view all the answers

Which of the following is a characteristic of acute inflammation?

<p>It is a protective response to eliminate the initial cause of cell injury. (B)</p> Signup and view all the answers

What are the two major events in acute inflammation?

<p>Vasodilation and increased vascular permeability. (D)</p> Signup and view all the answers

What are the five classic signs of acute inflammation?

<p>Heat, redness, swelling, pain, and loss of function. (B)</p> Signup and view all the answers

Which of the following is a characteristic of exudate?

<p>It is a thicker fluid, rich in proteins and immune cells (C)</p> Signup and view all the answers

What is the function of neutrophils' tertiary granules?

<p>To produce matrix metalloproteinases (D)</p> Signup and view all the answers

What is the role of reactive oxygen species in neutrophils?

<p>To eliminate bacteria (B)</p> Signup and view all the answers

Which of the following is a function of vasoactive amines?

<p>To promote arteriolar dilation and venular endothelial contraction (B)</p> Signup and view all the answers

Which of the following is NOT a phase of the cell cycle?

<p>G0 (A)</p> Signup and view all the answers

Which type of cell division gives rise to sperm and egg cells?

<p>Meiosis (D)</p> Signup and view all the answers

What is the chromosome number in diploid human cells?

<p>46 (B)</p> Signup and view all the answers

Which of the following inheritance patterns is characterized by the interaction of several genes?

<p>Polygenic (D)</p> Signup and view all the answers

Which of the following is a type of inheritance that is not Mendelian?

<p>Polygenic (C)</p> Signup and view all the answers

How are multi-gene (polygenic) defects different from Mendelian inheritance patterns?

<p>They involve multiple alleles (D)</p> Signup and view all the answers

Which process is responsible for generating genetic diversity in Meiosis I?

<p>Recombination (B)</p> Signup and view all the answers

What is the end result of DNA replication?

<p>Two DNA molecules, each with one old strand and one new strand (B)</p> Signup and view all the answers

Which type of necrosis is characterized by the transformation of solid tissue into a liquid mass and complete digestion of dead cells?

<p>Liquefactive necrosis (C)</p> Signup and view all the answers

What is the term used to describe the physical appearance of an organism based on its genetic constitution?

<p>Phenotype (A)</p> Signup and view all the answers

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Study Notes

Cell Injury and Response

  • Reversible response to cell injury: cellular adaptation
  • Physiological cause of hyperplasia: increased demand or stimuli

Cell Death

  • Main difference between necrosis and apoptosis: necrosis is uncontrolled and apoptosis is controlled
  • Type of necrosis characterized by transformation of solid tissue into a liquid mass and complete digestion of dead cells: liquefactive necrosis
  • Type of necrosis characterized by a distinctive cheesy, crumbly, white gross appearance and commonly associated with tuberculous infection: caseous necrosis
  • Type of necrosis characterized by preservation of cell shape and organ structure, with disappearance of nuclei: coagulative necrosis
  • Type of necrosis associated with necrotic damage to blood vessel walls and often occurs in the context of vasculitis: fibrinoid necrosis

Cellular Adaptation

  • Example of metaplasia: replacement of one type of epithelium with another
  • Cause of cell injury: genetic mutation, infection, toxins, etc.

Irreversible Cellular Injury

  • Consequence of irreversible cellular injury: cell death or necrosis

Membrane Damage

  • Role of free radicals in membrane damage: disrupts membrane structure and function

Acute Inflammation

  • Characteristic of acute inflammation: rapid onset, short duration
  • Two major events in acute inflammation: increased blood flow and increased permeability
  • Five classic signs of acute inflammation: redness, swelling, heat, pain, and loss of function
  • Characteristic of exudate: fluid rich in protein and cells
  • Function of neutrophils' tertiary granules: antibacterial properties
  • Role of reactive oxygen species in neutrophils: bactericidal effects
  • Function of vasoactive amines: regulate blood flow and permeability

Cell Division

  • Type of cell division that gives rise to sperm and egg cells: meiosis
  • Chromosome number in diploid human cells: 46

Inheritance Patterns

  • Inheritance pattern characterized by the interaction of several genes: polygenic inheritance
  • Type of inheritance that is not Mendelian: polygenic inheritance
  • Difference between multi-gene (polygenic) defects and Mendelian inheritance patterns: multiple genes contribute to the phenotype in polygenic inheritance
  • Process responsible for generating genetic diversity in Meiosis I: crossing over
  • End result of DNA replication: two identical daughter molecules

Miscellaneous

  • Term used to describe the physical appearance of an organism based on its genetic constitution: phenotype

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