Cell Injury and Death Concepts Quiz
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Questions and Answers

What is the first level at which noxious influences exert their effects?

  • Molecular or biochemical level (correct)
  • Cellular level
  • Tissue level
  • Organ level

How quickly can changes be detected in cells after injury using sensitive techniques?

  • Weeks
  • Minutes to hours (correct)
  • Only during post-mortem examination
  • Several days

Which of the following substances can have toxic side effects?

  • Carbohydrates
  • Therapeutic drugs (correct)
  • Proteins
  • Vitamins

What does cell swelling indicate in the case of ischemia in the myocardium?

<p>Ongoing cellular damage (D)</p> Signup and view all the answers

What is the approximate time frame for light microscopic evidence of cell death to appear after ischemia onset?

<p>4 to 12 hours (A)</p> Signup and view all the answers

Which of the following is not one of the infectious agents mentioned?

<p>Chemical toxins (C)</p> Signup and view all the answers

How long may morphologic manifestations of necrosis take to develop compared to reversible damage?

<p>They develop more slowly (C)</p> Signup and view all the answers

Which of the following is a factor that influences cell injury from biological agents?

<p>Diversity of mechanisms (D)</p> Signup and view all the answers

Which of the following is NOT a cause of cell injury related to nutritional imbalances?

<p>Mechanical trauma (D)</p> Signup and view all the answers

What is the primary consequence of severe hypoxia in cells?

<p>Cell death (C)</p> Signup and view all the answers

What role does obesity play in cell injury?

<p>It is associated with increased incidence of diseases. (D)</p> Signup and view all the answers

Which chemical is NOT mentioned as a potential cause of cell injury?

<p>Carbon monoxide (B)</p> Signup and view all the answers

What does a diet high in certain lipids increase the risk of?

<p>Atherosclerosis (D)</p> Signup and view all the answers

How can nutrient shortages be categorized?

<p>Self-imposed or stemming from food shortages (A)</p> Signup and view all the answers

What potential effect does high concentrations of oxygen have on cells?

<p>Is toxic to cells (D)</p> Signup and view all the answers

Which of the following physical agents does NOT typically cause cell injury?

<p>Regular exercise (A)</p> Signup and view all the answers

Which of the following is a common cause of cell injury associated with nutritional imbalances?

<p>Vitamin deficiency (B)</p> Signup and view all the answers

What is fat necrosis primarily characterized by?

<p>Destruction of fat tissue due to pancreatic lipases. (A)</p> Signup and view all the answers

What is the role of free radicals in cell injury?

<p>They contribute to oxidative stress and damage cellular components. (A)</p> Signup and view all the answers

Which of the following cellular adaptations leads to an increase in cell size?

<p>Hypertrophy (B)</p> Signup and view all the answers

What is a common outcome in gangrenous necrosis when bacterial infection occurs?

<p>Enhanced liquefactive necrosis. (A)</p> Signup and view all the answers

What is a key feature distinguishing necrosis from apoptosis?

<p>Necrosis typically results in inflammation. (A)</p> Signup and view all the answers

In which condition is caseous necrosis most commonly observed?

<p>Tuberculous infection. (D)</p> Signup and view all the answers

Which adaptation occurs in response to chronic stress or injury by increasing the number of cells?

<p>Hyperplasia (D)</p> Signup and view all the answers

What does saponification in fat necrosis result in?

<p>Visible chalky-white deposits. (B)</p> Signup and view all the answers

What is not a characteristic of liquefactive necrosis?

<p>Formation of caseous necrosis. (B)</p> Signup and view all the answers

Calcium homeostasis disturbances can lead to which type of cellular damage?

<p>Endoplasmic reticulum stress (D)</p> Signup and view all the answers

What type of necrosis is described as having a cheeselike appearance?

<p>Caseous necrosis. (D)</p> Signup and view all the answers

What mechanism primarily mediates the cell's response to severe oxidative stress?

<p>Apoptosis (D)</p> Signup and view all the answers

What characterizes Dystrophic Calcification in pathological conditions?

<p>Calcium deposits are often found in aging tissues with previous damage. (B)</p> Signup and view all the answers

Which form of necrosis is primarily related to immune reactions and affects blood vessels?

<p>Fibrinoid necrosis. (D)</p> Signup and view all the answers

Which of the following factors contributes significantly to Ischemia-Reperfusion injury?

<p>Reintroduction of oxygen leading to oxidative stress. (D)</p> Signup and view all the answers

What typically triggers the fat necrosis process in acute pancreatitis?

<p>Release of pancreatic lipases. (D)</p> Signup and view all the answers

Which type of cellular change does Metaplasia represent?

<p>Replacement of one type of cell with another type (D)</p> Signup and view all the answers

What is activated by the intrinsic mitochondrial pathway?

<p>Caspase-9 (B)</p> Signup and view all the answers

Which caspases are activated by the extrinsic death receptor pathway?

<p>Caspase-10 and Caspase-8 (A)</p> Signup and view all the answers

Which of the following best describes the role of executioner caspases?

<p>They cleave various cellular components. (D)</p> Signup and view all the answers

What distinguishes necroptosis from other cell death mechanisms?

<p>It involves a hybrid of necrosis and apoptosis. (C)</p> Signup and view all the answers

Which cellular components are primarily targeted for cleavage by executioner caspases?

<p>Various cellular components (D)</p> Signup and view all the answers

What initiates the extrinsic death receptor pathway?

<p>Interaction with surface receptors (A)</p> Signup and view all the answers

Which type of ligands are responsible for activating the extrinsic pathway?

<p>Both soluble and surface-expressed ligands (C)</p> Signup and view all the answers

What is a key feature of necrosis in comparison to apoptosis?

<p>Necrosis often leads to inflammation. (B)</p> Signup and view all the answers

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