Cell Injury and Adaptation
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Questions and Answers

Cell injury occurs when cells are stressed and cannot adapt to ______.

injury

Atrophy is a ______ process except when it is caused by loss of nerve supply.

reversible

Hypertrophy occurs when a cell or tissue is exposed to ______ workload.

increased

Metaplasia is a process in which one cell type is converted to ______ cell type.

<p>another</p> Signup and view all the answers

Prolonged smoking causes columnar epithelium to change to ______ epithelium in respiratory passages.

<p>stratified squamous</p> Signup and view all the answers

Chronic ______ or inflammation can cause metaplasia.

<p>irritation</p> Signup and view all the answers

Severe anemia reduces the ______ capacity of blood.

<p>oxygen-carrying</p> Signup and view all the answers

Chemical agents can alter ______ pressure around the cell, resulting in cell injury.

<p>osmotic</p> Signup and view all the answers

Infectious agents include ______, viruses, fungi, protozoa, and rickettsiae.

<p>bacteria</p> Signup and view all the answers

Cellular swelling is caused by the accumulation of ______ due to failure of active transporters and cell membrane integrity.

<p>water</p> Signup and view all the answers

Cellular accumulation can lead to the buildup of ______, protein, calcium, and uric acid.

<p>fats</p> Signup and view all the answers

Necrosis occurs due to ______, toxins, infections, and trauma.

<p>ischemia</p> Signup and view all the answers

Pyknosis is characterized by the nucleus ______

<p>shrinks</p> Signup and view all the answers

In Karyorrhexis, the pyknotic nucleus is ______

<p>fragmented</p> Signup and view all the answers

In Karyolysis, DNA is degraded by ______

<p>endonuclease</p> Signup and view all the answers

Coagulative Necrosis is characterized by dead cells, but tissue structure remains intact for ______ to ______

<p>days to weeks</p> Signup and view all the answers

In Liquefactive Necrosis, enzymes of leukocytes ______ the tissue

<p>digest</p> Signup and view all the answers

Liquefied necrotic tissue is creamy yellow due to the presence of ______

<p>dead leukocytes</p> Signup and view all the answers

The intrinsic pathway of apoptosis is activated in response to ______ damage or lack of oxygen or nutrients.

<p>DNA</p> Signup and view all the answers

Caspases have two actions: catalyze mass ______ in the cytoplasm and activate nucleases.

<p>proteolysis</p> Signup and view all the answers

The intrinsic pathway of apoptosis depends on ______ Activated from inside the cell.

<p>mitochondria</p> Signup and view all the answers

Bcl2 proteins are ______ regulators of apoptosis that control release of mitochondrial proteins to the cytoplasm.

<p>intracellular</p> Signup and view all the answers

Apoptosis depends on ______ proteins: proteolytic enzymes.

<p>Caspase</p> Signup and view all the answers

Released mitochondrial proteins activated ______ that catalyze mass proteolysis and activate nucleases.

<p>caspases</p> Signup and view all the answers

Bcl2 proteins cause dimerization of ______ proteins

<p>Bax and Bak</p> Signup and view all the answers

Cytochrome c in cytosol activates ______ which have two actions

<p>caspases</p> Signup and view all the answers

Cells fragment into membrane-bound pieces (apoptotic bodies), which are phagocytosed by ______

<p>macrophages</p> Signup and view all the answers

The induction of apoptosis by the mitochondrial pathway involves the action of sensors and effectors of the ______ family

<p>Bcl-2</p> Signup and view all the answers

Engagement of ______ receptors leads directly to caspase activation

<p>death</p> Signup and view all the answers

Mitochondrial proteins, especially ______, leak into cytosol

<p>cytochrome c</p> Signup and view all the answers

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