10 Questions
Which of the following accurately describes mechlorethamine?
It leaves a highly reactive aziridinium cation.
What is the purpose of administering sodium thiosulfate in cases of mechlorethamine extravasation?
To increase the water solubility of the resulting adduct.
How was the reactivity of mechlorethamine reduced in the development of chlorambucil and melphalan?
Both (a) and (b).
What is the purpose of the electron-withdrawing groups in cyclophosphamide and ifosfamide?
To require cytochrome P450 activation for aziridinium cation formation.
Which of the following is associated with bladder toxicity in cyclophosphamide and ifosfamide?
Acrolein, a potential electrophile.
What is the purpose of the reversible rearrangement in the liver for cyclophosphamide and ifosfamide?
To activate the compounds for aziridinium cation formation.
Which of the following statements about mechlorethamine is correct?
It is used in the treatment of Hodgkin's lymphoma.
What is the purpose of reducing the nucleophilicity of nitrogen in mechlorethamine analogues?
To slow down aziridinium cation formation.
Which of the following statements about the MOPP regimen is correct?
It stands for mechlorethamine, vincristine, procarbazine, and prednisone.
What is the purpose of attaching the nitrogen to a phenyl ring in chlorambucil and melphalan?
To reduce the reactivity of the compounds.
Test your knowledge on the different phases of the cell cycle and the states that cells can enter such as G1, G0, and M phase. Understand the importance of each phase in the cell's life cycle.
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