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Cell Cycle Phases and Cell States Quiz

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Questions and Answers

Which of the following accurately describes mechlorethamine?

It leaves a highly reactive aziridinium cation. (correct)

It is part of the CHOP regimen for lymphoma treatment.

It is used in the treatment of leukemia.

It is an enzyme-mediated reaction.

What is the purpose of administering sodium thiosulfate in cases of mechlorethamine extravasation?

To enhance the cytotoxic effects of mechlorethamine.

To increase the water solubility of the resulting adduct. (correct)

To prevent the formation of the aziridinium cation.

To neutralize the reactive aziridinium cation.

How was the reactivity of mechlorethamine reduced in the development of chlorambucil and melphalan?

By attaching the nitrogen to a phenyl ring.

By utilizing more highly electron-withdrawing groups as in cyclophosphamide.

By replacing the weakly electron-donating methyl group with electron-withdrawing groups.

Both (a) and (b). (correct)

What is the purpose of the electron-withdrawing groups in cyclophosphamide and ifosfamide?

To require cytochrome P450 activation for aziridinium cation formation. Signup and view all the answers

Which of the following is associated with bladder toxicity in cyclophosphamide and ifosfamide?

Acrolein, a potential electrophile. Signup and view all the answers

What is the purpose of the reversible rearrangement in the liver for cyclophosphamide and ifosfamide?

To activate the compounds for aziridinium cation formation. Signup and view all the answers

Which of the following statements about mechlorethamine is correct?

It is used in the treatment of Hodgkin's lymphoma. Signup and view all the answers

What is the purpose of reducing the nucleophilicity of nitrogen in mechlorethamine analogues?

To slow down aziridinium cation formation. Signup and view all the answers

Which of the following statements about the MOPP regimen is correct?

It stands for mechlorethamine, vincristine, procarbazine, and prednisone. Signup and view all the answers

What is the purpose of attaching the nitrogen to a phenyl ring in chlorambucil and melphalan?

To reduce the reactivity of the compounds. Signup and view all the answers