Podcast
Questions and Answers
Which of the following accurately describes mechlorethamine?
Which of the following accurately describes mechlorethamine?
- It leaves a highly reactive aziridinium cation. (correct)
- It is part of the CHOP regimen for lymphoma treatment.
- It is used in the treatment of leukemia.
- It is an enzyme-mediated reaction.
What is the purpose of administering sodium thiosulfate in cases of mechlorethamine extravasation?
What is the purpose of administering sodium thiosulfate in cases of mechlorethamine extravasation?
- To enhance the cytotoxic effects of mechlorethamine.
- To increase the water solubility of the resulting adduct. (correct)
- To prevent the formation of the aziridinium cation.
- To neutralize the reactive aziridinium cation.
How was the reactivity of mechlorethamine reduced in the development of chlorambucil and melphalan?
How was the reactivity of mechlorethamine reduced in the development of chlorambucil and melphalan?
- By attaching the nitrogen to a phenyl ring.
- By utilizing more highly electron-withdrawing groups as in cyclophosphamide.
- By replacing the weakly electron-donating methyl group with electron-withdrawing groups.
- Both (a) and (b). (correct)
What is the purpose of the electron-withdrawing groups in cyclophosphamide and ifosfamide?
What is the purpose of the electron-withdrawing groups in cyclophosphamide and ifosfamide?
Which of the following is associated with bladder toxicity in cyclophosphamide and ifosfamide?
Which of the following is associated with bladder toxicity in cyclophosphamide and ifosfamide?
What is the purpose of the reversible rearrangement in the liver for cyclophosphamide and ifosfamide?
What is the purpose of the reversible rearrangement in the liver for cyclophosphamide and ifosfamide?
Which of the following statements about mechlorethamine is correct?
Which of the following statements about mechlorethamine is correct?
What is the purpose of reducing the nucleophilicity of nitrogen in mechlorethamine analogues?
What is the purpose of reducing the nucleophilicity of nitrogen in mechlorethamine analogues?
Which of the following statements about the MOPP regimen is correct?
Which of the following statements about the MOPP regimen is correct?
What is the purpose of attaching the nitrogen to a phenyl ring in chlorambucil and melphalan?
What is the purpose of attaching the nitrogen to a phenyl ring in chlorambucil and melphalan?
