18 Questions
What is the function of CDC25 in the cell cycle?
De-phosphorylates CDK1
What role does Maturation-Promoting Factor (MPF) play in the cell cycle?
Stimulates both mitosis and meiosis
Which subunit of Maturation-Promoting Factor (MPF) uses ATP to add phosphate groups to specific serine and threonine residues on target proteins?
CDK1
Which term is often used to describe MPF due to its precise phosphorylation of target proteins during mitosis?
M Phase Kinase
How do mutations in tumor suppressor genes impact cell cycle control?
Lead to uncontrolled cell division
What is the function of the inhibitory enzyme Wee1 in the cell cycle?
Phosphorylates CDK1 at a specific tyrosine residue
Which specific sequence in cyclins leads to their destruction when recognized by the ubiquitin ligase enzyme?
Destruction box
What is the role of proto-oncogenes in cell proliferation?
Promote cell growth
What is the primary function of Cyclin-Dependent Kinase 1 (CDK1) in the cell cycle?
Adding phosphate groups to target proteins
Which gene product is associated with monitoring DNA damage as a tumor suppressor gene?
p53
What happens when Maturation-Promoting Factor (MPF) is recognized by ubiquitin ligase?
It leads to cyclin destruction when no longer needed
What happens when CDK1 binds to cyclin B in the cell cycle?
Activates MPF
What is the main function of Maturation-Promoting Factor (MPF) in the cell cycle?
Controls entry into mitosis
Which protein components make up Maturation-Promoting Factor (MPF)?
Cyclin B and Cdc2
What is another name for Cyclin-dependent kinase 1 (Cdk1)?
Cdc2
Which process is triggered by the activation of MPF in the cell cycle?
Cell division
What can result from the loss of cell cycle control?
Tumor formation
What role do Tumor Suppressor Genes play in cell growth?
Act as brakes in cell growth
This quiz covers the process of cell cycle control, focusing on the transition from G2 to M phase and the activation of Mitosis Promoting Factor (MPF). It also discusses how mutations in tumor suppressor genes or proto-oncogenes can impact cell cycle checkpoints.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
