Cell Cycle Control and Mutations in Tumor Suppressor Genes Quiz
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Questions and Answers

What is the function of CDC25 in the cell cycle?

  • Phosphorylates CDK1
  • Inhibits MPF
  • De-phosphorylates CDK1 (correct)
  • Activates MPF

    • What role does Maturation-Promoting Factor (MPF) play in the cell cycle?

  • Regulates protein synthesis in the G1 phase
  • Inhibits cell division in the G2 phase
  • Stimulates both mitosis and meiosis (correct)
  • Triggers DNA replication in the S phase

    • Which subunit of Maturation-Promoting Factor (MPF) uses ATP to add phosphate groups to specific serine and threonine residues on target proteins?

  • Ubiquitin ligase
  • Cyclin
  • CDK1 (correct)
  • Wee1

    • Which term is often used to describe MPF due to its precise phosphorylation of target proteins during mitosis?

    <p>M Phase Kinase</p> Signup and view all the answers

    How do mutations in tumor suppressor genes impact cell cycle control?

    <p>Lead to uncontrolled cell division</p> Signup and view all the answers

    What is the function of the inhibitory enzyme Wee1 in the cell cycle?

    <p>Phosphorylates CDK1 at a specific tyrosine residue</p> Signup and view all the answers

    Which specific sequence in cyclins leads to their destruction when recognized by the ubiquitin ligase enzyme?

    <p>Destruction box</p> Signup and view all the answers

    What is the role of proto-oncogenes in cell proliferation?

    <p>Promote cell growth</p> Signup and view all the answers

    What is the primary function of Cyclin-Dependent Kinase 1 (CDK1) in the cell cycle?

    <p>Adding phosphate groups to target proteins</p> Signup and view all the answers

    Which gene product is associated with monitoring DNA damage as a tumor suppressor gene?

    <p>p53</p> Signup and view all the answers

    What happens when Maturation-Promoting Factor (MPF) is recognized by ubiquitin ligase?

    <p>It leads to cyclin destruction when no longer needed</p> Signup and view all the answers

    What happens when CDK1 binds to cyclin B in the cell cycle?

    <p>Activates MPF</p> Signup and view all the answers

    What is the main function of Maturation-Promoting Factor (MPF) in the cell cycle?

    <p>Controls entry into mitosis</p> Signup and view all the answers

    Which protein components make up Maturation-Promoting Factor (MPF)?

    <p>Cyclin B and Cdc2</p> Signup and view all the answers

    What is another name for Cyclin-dependent kinase 1 (Cdk1)?

    <p>Cdc2</p> Signup and view all the answers

    Which process is triggered by the activation of MPF in the cell cycle?

    <p>Cell division</p> Signup and view all the answers

    What can result from the loss of cell cycle control?

    <p>Tumor formation</p> Signup and view all the answers

    What role do Tumor Suppressor Genes play in cell growth?

    <p>Act as brakes in cell growth</p> Signup and view all the answers

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