Podcast
Questions and Answers
What is the role of Cdk inhibitory proteins (CKIs) in the cell cycle?
What is the role of Cdk inhibitory proteins (CKIs) in the cell cycle?
- Stimulating chromosome attachment to the mitotic spindle
- Inactivating cyclin-Cdk complexes (correct)
- Promoting progression through G2 phase
- Activating cyclin-Cdk complexes
Which condition would prevent entry into the M phase of the cell cycle?
Which condition would prevent entry into the M phase of the cell cycle?
- DNA replication is not complete (correct)
- Abnormal cell size
- Presence of DNA damage
- Absence of growth factors
What happens at the end of mitosis regarding the M-cyclins?
What happens at the end of mitosis regarding the M-cyclins?
- They activate checkpoints for further cell division
- They are duplicated for future use
- They are targeted for destruction by APC/C (correct)
- They initiate cytokinesis
What is the primary role of Cdk inhibitory proteins (CKIs) early in the cell cycle?
What is the primary role of Cdk inhibitory proteins (CKIs) early in the cell cycle?
What condition would prevent progression through G1 phase of the cell cycle?
What condition would prevent progression through G1 phase of the cell cycle?
What is required for the completion of M phase in the cell cycle, including telophase and cytokinesis?
What is required for the completion of M phase in the cell cycle, including telophase and cytokinesis?
What are checkpoints in the cell cycle?
What are checkpoints in the cell cycle?
Which transition is considered the ratelimiting step of the cell cycle for most cells?
Which transition is considered the ratelimiting step of the cell cycle for most cells?
What regulates cell cycle checkpoints?
What regulates cell cycle checkpoints?
What happens if a cell detects a problem at a checkpoint?
What happens if a cell detects a problem at a checkpoint?
Which checkpoint is also known as the 'Start transition'?
Which checkpoint is also known as the 'Start transition'?
What role do specific signals play at cell cycle checkpoints?
What role do specific signals play at cell cycle checkpoints?
Which CKI inhibits the G1/S-cdk complex, S-cdk complex, and M-cdk complex?
Which CKI inhibits the G1/S-cdk complex, S-cdk complex, and M-cdk complex?
Which of the following statements about p53 is not true?
Which of the following statements about p53 is not true?
Which of the following complexes is not involved in stimulating chromosome duplication or early mitotic events?
Which of the following complexes is not involved in stimulating chromosome duplication or early mitotic events?
Which of the following statements about RB (Retinoblastoma protein) is true?
Which of the following statements about RB (Retinoblastoma protein) is true?
Which CKI inhibits the G1-cdk complex (Cyclin D-cdk4 & Cyclin D-cdk6)?
Which CKI inhibits the G1-cdk complex (Cyclin D-cdk4 & Cyclin D-cdk6)?
Which of the following statements about the M-Cdk complex (Cyclin B-cdk1) is false?
Which of the following statements about the M-Cdk complex (Cyclin B-cdk1) is false?
What is the primary function of cyclins in the cell cycle?
What is the primary function of cyclins in the cell cycle?
What is the role of cyclin-activating kinase (CAK) in the regulation of the cell cycle?
What is the role of cyclin-activating kinase (CAK) in the regulation of the cell cycle?
How do cyclin-Cdk complexes regulate different cellular processes during the cell cycle?
How do cyclin-Cdk complexes regulate different cellular processes during the cell cycle?
What is the role of the anaphase-promoting complex (APC/C) in the cell cycle?
What is the role of the anaphase-promoting complex (APC/C) in the cell cycle?
What is the mechanism by which the APC/C targets proteins for degradation?
What is the mechanism by which the APC/C targets proteins for degradation?
Which of the following statements about cyclins and cyclin-dependent kinases (Cdks) is correct?
Which of the following statements about cyclins and cyclin-dependent kinases (Cdks) is correct?
What is the primary function of DNA ligase during DNA replication?
What is the primary function of DNA ligase during DNA replication?
What is the primary cause of supercoiling during DNA replication?
What is the primary cause of supercoiling during DNA replication?
Which enzyme is responsible for relieving the superhelical tension caused by DNA unwinding during replication?
Which enzyme is responsible for relieving the superhelical tension caused by DNA unwinding during replication?
What is the primary function of histone chaperones during DNA replication in eukaryotes?
What is the primary function of histone chaperones during DNA replication in eukaryotes?
During which phase of the cell cycle does histone synthesis primarily occur in eukaryotes?
During which phase of the cell cycle does histone synthesis primarily occur in eukaryotes?
Which of the following statements accurately describes the role of DNA topoisomerase during DNA replication?
Which of the following statements accurately describes the role of DNA topoisomerase during DNA replication?
Which cyclin-Cdk complex is responsible for stimulating chromosome duplication during the S phase of the cell cycle?
Which cyclin-Cdk complex is responsible for stimulating chromosome duplication during the S phase of the cell cycle?
Which cyclin-Cdk complex is primarily responsible for triggering progression through the G1/S transition, also known as the 'Start transition'?
Which cyclin-Cdk complex is primarily responsible for triggering progression through the G1/S transition, also known as the 'Start transition'?
Which cyclin-Cdk complex is responsible for stimulating entry into the M phase of the cell cycle at the G2/M transition?
Which cyclin-Cdk complex is responsible for stimulating entry into the M phase of the cell cycle at the G2/M transition?
Which of the following statements about the role of the Cyclin D-Cdk4/6 complex in the cell cycle is correct?
Which of the following statements about the role of the Cyclin D-Cdk4/6 complex in the cell cycle is correct?
Which of the following statements about the role of the Cyclin A-Cdk1/2 complex in the cell cycle is correct?
Which of the following statements about the role of the Cyclin A-Cdk1/2 complex in the cell cycle is correct?
Which of the following statements about the role of the Cyclin B-Cdk1 complex in the cell cycle is false?
Which of the following statements about the role of the Cyclin B-Cdk1 complex in the cell cycle is false?
How does Akt promote cell cycle progression?
How does Akt promote cell cycle progression?
Which of the following is not a role of Akt in the cell cycle?
Which of the following is not a role of Akt in the cell cycle?
What is the main function of p21 and p27 in relation to the cell cycle?
What is the main function of p21 and p27 in relation to the cell cycle?
Which enzyme regulates the checkpoint that is not regulated by cyclin-Cdk complexes?
Which enzyme regulates the checkpoint that is not regulated by cyclin-Cdk complexes?
How do p16, p21, and p27 affect the cell cycle?
How do p16, p21, and p27 affect the cell cycle?
What is the function of RB in stopping the cell cycle?
What is the function of RB in stopping the cell cycle?
Which phase of the cell cycle is characterized by the synthesis of enzymes, proteins, and ATP, as well as continued cell growth?
Which phase of the cell cycle is characterized by the synthesis of enzymes, proteins, and ATP, as well as continued cell growth?
During which phase does DNA replication occur, creating two identical daughter genomes?
During which phase does DNA replication occur, creating two identical daughter genomes?
The duration of the M phase, where the cell undergoes mitosis and cytokinesis, typically lasts how long in a mammalian cell with a 16-hour cycle?
The duration of the M phase, where the cell undergoes mitosis and cytokinesis, typically lasts how long in a mammalian cell with a 16-hour cycle?
Which phase is considered the rate-limiting step of the cell cycle for most cells?
Which phase is considered the rate-limiting step of the cell cycle for most cells?
In which phase do growth factors play a crucial role in determining whether a cell proceeds with division or enters a quiescent state?
In which phase do growth factors play a crucial role in determining whether a cell proceeds with division or enters a quiescent state?
Which phase is typically the shortest in duration for a mammalian cell with a 16-hour cycle?
Which phase is typically the shortest in duration for a mammalian cell with a 16-hour cycle?
What is the primary mechanism by which DNA polymerase ensures high fidelity during DNA replication?
What is the primary mechanism by which DNA polymerase ensures high fidelity during DNA replication?
What is the primary reason that the error rate during DNA replication is much lower than the error rate during transcription (RNA polymerase)?
What is the primary reason that the error rate during DNA replication is much lower than the error rate during transcription (RNA polymerase)?
What is the primary function of the 3'-to-5' exonuclease activity of DNA polymerase during proofreading?
What is the primary function of the 3'-to-5' exonuclease activity of DNA polymerase during proofreading?
Which of the following is NOT a proofreading mechanism used by DNA polymerase during DNA replication?
Which of the following is NOT a proofreading mechanism used by DNA polymerase during DNA replication?
What is the primary reason that the error rate during DNA replication is approximately 1 mistake per $10^{10}$ nucleotides, which is much lower than the error rate during transcription (RNA polymerase)?
What is the primary reason that the error rate during DNA replication is approximately 1 mistake per $10^{10}$ nucleotides, which is much lower than the error rate during transcription (RNA polymerase)?
What is the primary function of the strand-directed mismatch repair system mentioned in the text?
What is the primary function of the strand-directed mismatch repair system mentioned in the text?
What is the role of DNA ligase in DNA replication?
What is the role of DNA ligase in DNA replication?
How does DNA topoisomerase contribute to DNA replication?
How does DNA topoisomerase contribute to DNA replication?
What is a key function of histone chaperones during DNA replication?
What is a key function of histone chaperones during DNA replication?
Which enzyme is responsible for relieving supercoiling tension during DNA replication?
Which enzyme is responsible for relieving supercoiling tension during DNA replication?
In DNA replication, what is the main task of DNA topoisomerase?
In DNA replication, what is the main task of DNA topoisomerase?
During which phase of the cell cycle is histone synthesis primarily carried out in eukaryotes?
During which phase of the cell cycle is histone synthesis primarily carried out in eukaryotes?
