Podcast
Questions and Answers
What role do kinetochores play in cell division?
What role do kinetochores play in cell division?
- They promote tumor growth.
- They enable cells to divide regardless of external signals.
- They send signals to delay anaphase if not attached to spindle microtubules. (correct)
- They inhibit cell growth.
How does platelet-derived growth factor (PDGF) affect cells?
How does platelet-derived growth factor (PDGF) affect cells?
- It inhibits cell motility.
- It causes density-dependent inhibition in cells.
- It prevents cells from attaching to the substratum.
- It stimulates growth, changes cell shape and motility, and promotes chemotaxis. (correct)
What phenomenon describes the behavior of crowded cells in terms of division?
What phenomenon describes the behavior of crowded cells in terms of division?
- Density-dependent inhibition. (correct)
- Apoptosis.
- Cell differentiation.
- Tumorigenesis.
What is a requirement for animal cells to divide regarding anchorage dependence?
What is a requirement for animal cells to divide regarding anchorage dependence?
How do cancer cells differ in their growth behaviors compared to normal cells?
How do cancer cells differ in their growth behaviors compared to normal cells?
Flashcards
Checkpoints
Checkpoints
Control points in the cell cycle that ensure accurate progression to the next phase.
Internal signal
Internal signal
A signal within the cell that controls the cell cycle.
Kinetochores
Kinetochores
Protein structures on chromosomes that attach to spindle fibers during cell division.
Spindle microtubules
Spindle microtubules
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Anaphase delay
Anaphase delay
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External Signal
External Signal
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Growth Factors
Growth Factors
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PDGF
PDGF
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Density-dependent inhibition
Density-dependent inhibition
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Anchorage dependence
Anchorage dependence
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Cancer cell
Cancer cell
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Study Notes
Cell Cycle Checkpoints
- Internal signals: Kinetochores not attached to spindle microtubules send signals delaying anaphase. This ensures proper chromosome segregation.
External Signals
- Growth factors: Proteins released by certain cells stimulate division in other cells.
- Example: Platelet-derived growth factor (PDGF) binds to cell receptors, promoting growth, shape changes, movement, and chemotaxis.
- Density-dependent inhibition: Crowded cells stop dividing.
- Anchorage dependence: Animal cells require attachment to a substratum to divide.
Cancer Cell Characteristics
- Cancer cells disregard density-dependent inhibition and anchorage dependence.
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Description
Explore the mechanisms of cell cycle checkpoints and their significance in cancer biology. This quiz covers internal and external signals that regulate cell division, as well as the characteristics of cancer cells that circumvent these regulations. Test your understanding of these critical biological concepts.
