Cell Biology Concepts

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Questions and Answers

Which labeled cell in the diagram actively synthesizes and secretes an antigen-binding protein?

  • C
  • B
  • D
  • A (correct)
  • E

A protein being translated on a cytoplasmic ribosome is directed to the endoplasmic reticulum because

  • the protein is recognized by a specific oligosaccharide receptor found only in the endoplasmic reticulum
  • dolichol recognizes hydrophobic amino acids in the primary structure of the protein
  • a hydrophobic signal sequence is encoded into the protein at its amino terminus (correct)
  • the protein contains a consensus sequence for glycosylation

The proliferation of uterine endometrium depends on:

  • Estrogen (correct)
  • Prolactin
  • Progesterone
  • Luteinizing Hormone
  • Cortisol

Which of the following cell types are found exclusively in the basal compartment of the seminiferous tubules?

<p>Spermatogonia (B)</p> Signup and view all the answers

A suitable marker for determining that cells have differentiated into epidermal epithelial tissue is expression of

<p>keratin (B)</p> Signup and view all the answers

Which region of the graph best portrays these cells in metaphase II?

<p>C (B)</p> Signup and view all the answers

In the renal cortex, the labyrinth of capillaries that carry resorbed glucose out of the kidney arises directly from the:

<p>efferent arterioles (E)</p> Signup and view all the answers

The direct signal transduction event that follows binding of growth factor to its receptor at the cell surface is:

<p>phosphorylation of tyrosine residues in receptor proteins (A)</p> Signup and view all the answers

A patient ingests an overdose of a barbiturate. Which of the following will show the greatest increase in hepatocytes 2 days later?

<p>Smooth endoplasmic reticulum (A)</p> Signup and view all the answers

During the final stage of secretory glycoprotein formation, before exocytosis, glycoproteins are found in the:

<p>trans Golgi complex (A)</p> Signup and view all the answers

The synthesis of rRNA is associated most specifically with which of the following cell structures?

<p>Nucleolus (B)</p> Signup and view all the answers

Beating of cilia is mediated by:

<p>dynein arms (D)</p> Signup and view all the answers

Which of the following muscles is composed of multinucleated myocytes?

<p>Inferior pharyngeal constrictor (C)</p> Signup and view all the answers

During hematopoiesis, the differentiation of promyelocytes into neutrophilic myelocytes is recognized primarily by the appearance of:

<p>specific granules (E)</p> Signup and view all the answers

Which of the following cell processes is illustrated in the diagram?

<p>Endocytosis (A)</p> Signup and view all the answers

The blood-brain barrier excludes which of the following molecules from the brain parenchyma?

<p>Albumin (D)</p> Signup and view all the answers

Erythroid cells with hyperchromatic nuclei and eosinophilic cytoplasm are observed in a peripheral blood smear of a 35-year-old woman with chronic anemia. These cells are most likely to be

<p>orthochromatic erythroblasts (E)</p> Signup and view all the answers

Which of the following differentiates capillaries in the brain from those in the gut?

<p>Absence of endothelial cell membrane fenestrations (D)</p> Signup and view all the answers

In contrast to extrafusal muscle fibers, intrafusal fibers contain

<p>stretch-sensitive nerve endings (C)</p> Signup and view all the answers

Cells will accumulate in which of the following phases of the cell cycle if they are cultivated in the presence of a chemical agent that is capable of blocking the cell cycle immediately after DNA synthesis has been completed?

<p>G2 (B)</p> Signup and view all the answers

A tumor was stained with a panel of monoclonal antibodies directed against various classes of intermediate filaments. The tumor stained positively with antiglial fibrillary acidic protein (anti-GFAP), indicating its derivation from

<p>astrocytes (C)</p> Signup and view all the answers

The structures labeled X are

<p>factory receptor cells (B)</p> Signup and view all the answers

To demonstrate graft-versus-host rejection to her students, an immunologist grafts the skin of a black male mouse onto an albino female mouse. The graft is rejected. Which of the following cell types present in the skin adjacent to the graft migrated into the graft to initiate an immunologic response?

<p>Lymphocytes (C)</p> Signup and view all the answers

The most likely cause of autosomal trisomy is:

<p>nondisjunction during oogenesis (D)</p> Signup and view all the answers

For the oocyte, meiosis is completed at the time of which of the following events?

<p>Sperm entry into the secondary oocyte (B)</p> Signup and view all the answers

Which of the following evidence most strongly supports the hypothesis that, during development, muscles release a chemical trophic substance that acts on neurons?

<p>Partial denervation of muscle causes sprouting from intact axons that innervate the denervated muscle cells (B)</p> Signup and view all the answers

Drugs, including alcohol, increase the number of detoxifying enzymes in liver by extensive proliferation of which of the following cellular components?

<p>Smooth endoplasmic reticulum (C)</p> Signup and view all the answers

Which lettered structure on the diagram of muscle is most active during generation of energy necessary for contraction?

<p>B (E)</p> Signup and view all the answers

The most abundant type of cell within the fovea of the retina centralis is the

<p>cone (D)</p> Signup and view all the answers

In an adult male, what is the most likely consequence of the absence of secretion of interstitial cell-stimulating hormone?

<p>Atrophy of the prostate and seminal vesicles (B)</p> Signup and view all the answers

The cell type most responsible for recognition and rejection of foreign tissue in organ transplants is the

<p>T lymphocyte (E)</p> Signup and view all the answers

The differences in somatic cells in adults is the result of differences in which of the following?

<p>mRNAs (E)</p> Signup and view all the answers

Axons are characterized by the absence of which of the following organelles?

<p>Rough endoplasmic reticulum (B)</p> Signup and view all the answers

Which of the following cartilages is dependent on diffusion of nutrients from synovial fluid?

<p>Anulus fibrosus of the intervertebral d (E)</p> Signup and view all the answers

The chart represents the changing amounts of RNA and hemoglobin in the erythroblast during erythrocyte formation. Which point best characterizes the condition found in the basophilic erythroblast?

<p>Point X (C)</p> Signup and view all the answers

A core of helical F-actin filaments provides the skeletal framework for

<p>microvilli (D)</p> Signup and view all the answers

Diploid cell of yolk sac origin

<p>B (A)</p> Signup and view all the answers

Which of the following structures is labeled X in the photograph?

<p>Terminal bronchiole (D)</p> Signup and view all the answers

Mitoses in this structure are responsible for longitudinal growth of bone.

<p>Epiphyseal plate (B)</p> Signup and view all the answers

Flashcards

Plasma Cell

Cell actively synthesizing and secreting antigen-binding proteins. Key component of the humoral immune response.

proliferation of uterine

proliferation depends on Estrogen, Estrogen establishes secretory~ progesterone

Hydrophobic Signal Sequence

Sequence in a protein directs it to the endoplasmic reticulum, initiating protein synthesis and translocation into the ER lumen.

Spermatogonia

Basal compartment of the seminiferous tubules that support and nourish developing sperm cells.

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Efferent Arterioles

Labryinth of capillaries that carry resorbed glucose out of the kidney

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Tyrosine Residues

Direct signal transduction event after growth factor binding

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Smooth Endoplasmic Reticulum

Organelle increase in hepatocytes 2 days later after drug overdose

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Nucleolus

rRNA synthesis is a function of this cell structure:

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Endocrine gland

This is most likely to be found in fenestrated capillaries.

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orthochromatic erythroblasts

Cells with hyperchromatic nuclei and eosinophilic cytoplasm are observed in a peripheral blood smear

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Albumin

Molecules excluded from the brain parenchyma by the blood-brain barrier

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Tight Junctions

Epithelial cells form a tight seal that prevents leakage

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C2

Region of the graph best portrays cells in metaphase II.

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Spectrin

A point mutation in this protein causes spherocytosis

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Mesenchymal stem cells

Cell with the potential to differentitate into osteocytes, chondrocytes, and adipocytes?

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G2 Phase

Accumulation of cells occurs in this phase if a chemical agent has blocked the cell cycle immediately after DNA synthesis

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Astrocytes

Tumor cells stained with anti-GFAP, therefore it is derived from

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Pacinian Corpuscles

Sensations of a tuning fork are detected by

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Geniculate Ganglia

Taste buds on the anterior two thirds of the tongue innervate processes of cells in these ganglia

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Smooth Endoplasmic Reticulum

Extensive proliferation leads to this cellular changes

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Study Notes

  • Plasma cells are active in synthesizing and secreting antigen-binding proteins.

  • The proliferation of uterine endometrium depends on estrogen.

  • Spermatogonia are exclusively located in the basal compartment of the seminiferous tubules.

  • Keratin expression indicates cells have differentiated into epidermal epithelial tissue.

  • A protein translated on a cytoplasmic ribosome is directed to the endoplasmic reticulum because it has a hydrophobic signal sequence encoded at its amino terminus.

  • In the renal cortex, efferent arterioles directly supply the labyrinth of capillaries that carry resorbed glucose out of the kidney.

  • Region C (level 2) on the graph likely represents cells in metaphase II during spermatogenesis.

  • Following growth factor binding to its receptor, phosphorylation of tyrosine residues in receptor proteins is the direct signal transduction event.

  • After a barbiturate overdose, the greatest increase in hepatocytes after 2 days will be smooth endoplasmic reticulum.

  • During the final stage of secretory glycoprotein formation, glycoproteins are found in the trans Golgi complex

  • Synthesis of rRNA is specifically associated with the nucleolus.

  • Beating of cilia is mediated by dynein arms.

  • Long straight endometrial glands with narrow lumens in a thick stratum functionale are consistent with diminished activity of granulosa lutein cells in the ovary.

  • Detrusor muscle of the bladder consists of multinucleated myocytes.

  • In hematopoiesis, the differentiation of promyelocytes into neutrophilic myelocytes is marked primarily by the appearance of specific granules.

  • The cell process illustrated in the diagram is endocytosis.

  • The blood-brain barrier excludes albumin from the brain parenchyma.

  • A substance of low molecular weight being injected into a cell, with electron microscopy showing gap junctions, indicates electrical coupling.

  • Fenestrated capillaries are located in endocrine glands.

  • Erythroid cells with hyperchromatic nuclei and eosinophilic cytoplasm are likely orthochromatic erythroblasts.

  • Brain capillaries differ from those in the gut by the absence of endothelial cell membrane fenestrations.

  • Intrafusal fibers contain stretch-sensitive nerve endings, unlike extrafusal muscle fibers.

  • Spherocytosis can result from a point mutation in spectrin(protein A).

  • Cells will accumulate in the G2 phase if cultivated with an agent that blocks the cell cycle after DNA synthesis.

  • In demonstrating graft-versus-host rejection, lymphocytes migrate into the graft to initiate an immunologic response.

  • Nondisjunction during oogenesis is the most likely cause of autosomal trisomy

  • Dense, spherical granules in the mammalian heart store atrial natriuretic peptide which lowers blood pressure.

  • Supporting the hypothesis that muscles release a chemical trophic substance is partial denervation causing sprouting from intact axons that innervate denervated muscle cells.

  • Olfactory receptor cells. are the structures labeled X in the diagram of the olfactory epithelium.

  • For the oocyte, meiosis is completed at sperm entry into the secondary oocyte, known as fertilization.

  • Drugs, including alcohol, increase detoxifying enzymes in the liver through extensive proliferation of smooth endoplasmic reticulum.

  • The sarcoplasmic reticulum(structure A) is most active during energy generation for muscle contraction.

  • Cones are the most abundant type of cell within the fovea of the retina centralis.

  • Absence of interstitial cell-stimulating hormone(ICSH) will most likely cause atrophy of the prostate and seminal vesicles.

  • The key difference between somatic cells in adults is in their mRNAs.

  • Precursors of goblet cells migrate from superior to inferior in the wall the proximal intestine, during weeks 8-12 of gestation.

  • Axons lack rough endoplasmic reticulum.

  • The annulus fibrosus is dependent on diffusion of nutrients from synovial fluid.

  • Schwann cells are important in promoting axonal regrowth after ulnar nerve transaction.

  • A white belly spot and tail caused by a recessive genetic mutation indicates that melanocytes are most likely impacted..

  • Microvilli rely on a core of helical F-actin filaments for their skeletal framework.

  • Tumor cells promote endothelial cell proliferation and angiogenesis primarily through fibroblast growth factor (FGF) secretion.

  • Basophilic erythroblast can be recognized in the chart through Point Y where the hemoglobin is increasing but the amount of RNA diminishes

  • The pacinian corpuscles are most likely to detect the vibrations of a tuning fork.

  • The geniculate ganglia innervates the taste buds on the anterior two thirds of the tongue.

  • Purkinje's cell fibers provide the only output of the cerebellar cortex.

  • The Arrows indicate structures that are directly regulated by secretions of the follicular cells of the thyroid.

  • Supraoptic nuclei secrete oxytocin into the circulation.

  • The Clara cell are the most characteristic cell types of terminal bronchioles.

  • Mucus comes from the muscus on the alveolar ducts of of a a 12 year old girl with chronic athsma that is coughing up large amounts of mucus.

  • Periodic acid-Schiff (PAS) aining clearly shows abundant secretions of mucus in the bronchial epithelium.

  • Structure A in the respiratory tissue photomicrograph shows the most proximal region where respiration occurs.

  • increased activity of succinic dehydrogenase found in relatively less active, which must develop tension for long periods of time (eg, antigravity muscles) muscles

  • The destruction of Folliculostellate cells in the hypothalamus can result in increased secretion of a product if the anterior pitutary is no longer under hypothalmic control.

  • A genetic mutation that renders kinesin incapable of binding to microtubules is most likely to impair fast axonal transport

  • Rigor mortis is caused by ATP depletion with muscle relaxation requires ATP, thus myofibrils remain in a contracted state in the absence of neuronal stimulation

  • Meissner's corpuscles are structures arrows are pointing to in skin is specialized to transduce light touch that the sensory stimuli into action potentials

  • Sertoli cells prevent interaction between developing sperm and the immune system.

  • The Zona fasciculata will result in decreased thickness to chronic administration of glucocorticoids

  • fetal capillaries, and trophoblastic cells separate the maternal from fetal circulation.

  • Arterioles are the structures responsible for a fair-skinned woman's skin becomes pale and cold because the blood is diverted away from the capillary bed in the superficial layers of the dermis.

  • Thhe epithelium lining that is likely to be the site of a primary squamous cell carcinoma is the vagina.

  • The ducts of apocrine sweat glands are characteristically lined with are characteristically lined with Stratified cuboidal.

  • Multilaminar bodies in type II pneumocytes produce a substance that lowers alveolar surface tension

  • Epithelial cells derived from the pharyngeal pouches are the in the determining influence on the differentiation of T lymphocytes

  • Lung: The polypeptide with a molecular weight of 500 daltons that is most likely to remain in the blood bed introduced into the circulation through an intravenous drip

  • Acidophils can be responsible for abnormally rapid growth, administration of somatostatin will depress secretion for those cells in the pituitary gland

  • rough endoplasmic reticulum membrane, translocation of protein from the ribosome into the lipid bilayer of a membrane occurs most frequently at the level of the

  • Initial glycosylation of glycoproteins occurs at the structure C on the electron micrograph of cells of a gastric gland

  • spermatogonis/E are the in prepubertal boys, cells within the seminiferous tubules.

  • Satellite cells are the new skeletal muscle can be after injury is in skeletal muscle

  • Progesterone secretory phase of the endometrium is directly controlled by

  • laminin molecule that promotes adhesion of epithelial cells to the basement membrane

  • smooth endoplasmic reticulum is the aintedstupidgouples istic of cells

  • portion "B" in the electron micrograph that is directly with the proximal tubule is cell the layer that is directly for a normal adult kidney

  • DHGA is coming from zona recticularis region of the gland Adrenal gland due to facial coarse

  • Proton pump (E)is where a proton pump is

  • longintudinal growth: Is located at the epiphyseal plate

  • A epiphyseal area: epiphysea are has secondary area B-galactosidase Activity at the cell surface:A decrease in best explains woman that has milk product and pain in her stomach. incorporate choline into surfactant.Injection of 'H-labeled choline into the systemic circulation of Because they incorporate choline into surfactant

  • hyaline cartilage II triple helix. type mutation.

  • Merkel's cells are a the reduced.

  • longintudinal growth: Is located at the ephiphyseal plate

  • B proton Pump for the the high conc of protons

  • B is basilar memrbane has cell assoiated with axonal endings

  • FiberoBlast can be what makes a woud in face to decreases

  • The doudenum relases enezyme exocrine pancrease for the digestion of enzymes primarily

  • proximal convoluted tubule reabsoption for the protein from glomerous filtration has through protein

  • mMelanosome for the for transfere the dermar skin or other place

  • Thick ascending limb, absence basul interdetions . absence brushes

  • villis absoroption eputlehal cells can syntheszie

  • "Z" line or Z dsis are simillar

  • after mitosis the amount of Dna is A

  • Collagen fiber Type 2 for the matrix nasal is inhlaeed

  • afferent arteriole for the renin secrtung are in the Kidney

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