Cell Biology and Pathology Quiz
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Questions and Answers

What is a possible consequence of a high lipid diet, according to the text?

  • Increased risk of anemia
  • Increased risk of cancer
  • Increased risk of cardiovascular diseases (correct)
  • Increased risk of diabetes
  • What is a common morphological change observed in cells undergoing reversible injury?

  • Formation of apoptotic bodies
  • Cell swelling (correct)
  • Nuclear fragmentation
  • Loss of cell membrane integrity
  • Which of the following is NOT a cellular change associated with mitochondrial alterations during reversible injury?

  • Dilation of the endoplasmic reticulum (ER)
  • Swelling
  • Appearance of small amorphous densities
  • Formation of apoptotic bodies (correct)
  • What is the main difference between reversible cell injury and cell death?

    <p>Reversible cell injury is a temporary state, while cell death is a permanent state. (B)</p> Signup and view all the answers

    What is a possible cause of nutritional imbalances leading to cellular injury?

    <p>Overnutrition (C)</p> Signup and view all the answers

    What is the primary function of columnar epithelium?

    <p>Absorption and secretion (C)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of cuboidal epithelium?

    <p>Lines the surface of the stomach (A)</p> Signup and view all the answers

    What is the name of the condition where there is a deficiency of oxygen?

    <p>Hypoxia (B)</p> Signup and view all the answers

    Which type of epithelium is characterized by cells being taller than they are wide?

    <p>Columnar epithelium (C)</p> Signup and view all the answers

    What is the function of the nervous system?

    <p>Carries nerve impulses to and from the brain and spinal cord (C)</p> Signup and view all the answers

    What is the primary focus of surgical pathology?

    <p>Analyzing the structure and appearance of tissues and organs. (D)</p> Signup and view all the answers

    Which of the following is NOT a branch of anatomic pathology?

    <p>Blood banking (D)</p> Signup and view all the answers

    Which of the following is NOT a category of injurious stimuli mentioned in the text?

    <p>Infections (A)</p> Signup and view all the answers

    What is the main purpose of studying biopsy specimens in anatomic pathology?

    <p>To identify and classify diseases. (B)</p> Signup and view all the answers

    What is the difference between a postmortem examination and a surgical pathology examination?

    <p>Postmortem exams are conducted to determine the cause of death, while surgical pathology exams are used to diagnose and classify diseases in living patients. (D)</p> Signup and view all the answers

    Which of the following is another term for hypoxia?

    <p>Anoxia (A)</p> Signup and view all the answers

    How does the study of tissue histology contribute to the understanding of diseases?

    <p>It reveals changes in cell structure and organization that may indicate disease. (B)</p> Signup and view all the answers

    Which of the following is a benefit of analyzing specific markers in patients?

    <p>It allows for personalized medical care and treatment. (B)</p> Signup and view all the answers

    How does anatomic pathology contribute to the field of transplantation?

    <p>By identifying suitable donor organs. (D)</p> Signup and view all the answers

    What is the primary focus of the 'Clinical immunology and serology' branch of pathology?

    <p>Studying the body's immune response to diseases. (B)</p> Signup and view all the answers

    What is the primary goal of quality assurance programs in laboratories?

    <p>To improve the potential care or safety (D)</p> Signup and view all the answers

    Which organization is NOT mentioned as providing data for quality assessment programs?

    <p>World Health Organization (WHO) (B)</p> Signup and view all the answers

    How does the Quality Control (QC) data function in relation to Quality Assurance (QA)?

    <p>QC data correlates results with actual known results. (C)</p> Signup and view all the answers

    What does NEQAS stand for?

    <p>National External Quality Assessment Service (D)</p> Signup and view all the answers

    What opportunity does continuing quality improvement focus on in laboratory systems?

    <p>Recognizing potential problems before they occur (A)</p> Signup and view all the answers

    What is the primary function of the objective lens in a compound microscope?

    <p>To focus the image before it reaches the ocular lens (B)</p> Signup and view all the answers

    Which component of the microscope allows the adjustment of light intensity on the slide?

    <p>Condenser lenses (A)</p> Signup and view all the answers

    How does resolution in microscopy generally defined?

    <p>The ability to distinguish between small objects that are close together (D)</p> Signup and view all the answers

    What is the disadvantage of using a monocular microscope compared to other types?

    <p>The usage of an LCD camera is restricted (A)</p> Signup and view all the answers

    Which part of the microscope provides the means to focus the image in a coarse manner?

    <p>Coarse focusing knob (B)</p> Signup and view all the answers

    What does the stage of a microscope typically enable?

    <p>To hold the slide in place while allowing movement (C)</p> Signup and view all the answers

    Which component is used to change the size of the beam of light coming through the stage?

    <p>Iris diaphragm (B)</p> Signup and view all the answers

    What characteristic of a microscope enables it to display details of an object clearly?

    <p>Resolution (D)</p> Signup and view all the answers

    What does the term 'pathogenesis' refer to?

    <p>The development of a disease or morbid condition (C)</p> Signup and view all the answers

    Which of the following roles is a pathologist primarily responsible for?

    <p>Interpreting and diagnosing diseases through microscopic analysis (D)</p> Signup and view all the answers

    According to Rudolf Virchow, where do all diseases originate?

    <p>At a cellular level (A)</p> Signup and view all the answers

    What is the primary focus of the study of pathology?

    <p>The structural and functional changes in cells, tissues, and organs (D)</p> Signup and view all the answers

    Which branch of medical science is primarily concerned with the examination of surgically removed organs and tissues?

    <p>Pathology (B)</p> Signup and view all the answers

    What characterizes a selective system in the context of histopathologic preparations?

    <p>It consists of stained preparations from specific archival records (B)</p> Signup and view all the answers

    Which term best describes the study of cellular abnormalities associated with diseases?

    <p>Pathobiology (A)</p> Signup and view all the answers

    In pathology, which of the following is least likely to be examined?

    <p>Patient psychological history (B)</p> Signup and view all the answers

    Flashcards

    Magnification

    The process of enlarging the appearance of an object without increasing its size.

    Resolution

    The shortest distance between two points that can still be distinguished as separate.

    Resolving Power

    Ability of the microscope to distinguish between small objects that are close together.

    Ocular (Eyepiece)

    The lens you look through at the top of the microscope, typically magnifies 10x.

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    Coarse Focusing Knob

    Adjusts the focus of the microscope quickly, moving the stage up and down.

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    Objective Lens

    The lens closest to the specimen, magnifying the image further (various powers).

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    Condenser Lenses

    Focuses light onto the specimen for better visibility.

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    Field (Iris) Diaphragm

    Controls the amount of light reaching the specimen to improve contrast.

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    Quality Control (QC)

    Data provided for evaluating laboratory results and processes.

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    Quality Assurance (QA)

    Programs that monitor and improve the quality of lab work.

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    College of American Pathologists (CAP)

    An organization that provides quality assessment programs for labs.

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    UK NEQAS

    United Kingdom National External Quality Assessment Service, assessing lab accuracy.

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    Continuous Quality Improvement (CQI)

    Ongoing evaluations to identify and improve lab processes.

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    Pathology

    The study of diseases and their effects on the body.

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    Pathogenesis

    The development and origin of a disease or morbid condition.

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    Pathobiology

    Another name for the study of diseases and their biological basis.

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    Pathologist

    A physician who studies diseases to diagnose them.

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    Histopathology

    The examination of tissue samples to diagnose diseases.

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    Biopsy

    A surgical procedure to remove and examine tissue for diagnosis.

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    Autopsy

    The examination of a body post-mortem to determine cause of death.

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    Cellular abnormalities

    Changes in cell structure and function due to disease.

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    Anatomic Pathology

    Study of the structure and appearance of organs and tissues after death.

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    Surgical Pathology

    Study of disease pathology, tissue appearance, and histology during surgical procedures.

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    Branches of Clinical Pathology

    Includes blood banking, hematology, clinical chemistry, immunology, and microbiology.

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    Blood Banking

    A branch focusing on the collection, testing, and distribution of blood.

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    Hematology

    The study of blood, its components, and blood diseases.

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    Clinical Chemistry

    Involves biochemical analysis of bodily fluids like blood and urine.

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    Clinical Immunology

    Study of the immune system and its disorders.

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    Microbiology

    Study of microscopic organisms, including bacteria, viruses, and fungi.

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    Blunting

    A condition due to excess, often seen in obesity.

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    Mitochondrial Changes

    Alterations such as dilated ER and small amorphous densities in cells.

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    Cell Death

    A biological process where a cell ceases to perform its functions; can be reversible or irreversible.

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    Reversible Cell Injury

    A state where a cell shows changes but may recover, like swelling or microvilli loss.

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    Atherosclerosis

    A condition caused by high lipid diet leading to elevated cholesterol, increasing heart disease risk.

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    Nerve impulse propagation

    The process of transmitting signals along nerve cells.

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    Squamous epithelium

    A flat tissue type, often found in areas needing diffusion or filtration.

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    Cuboidal epithelium

    Cube-shaped cells, often involved in secretion and absorption.

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    Columnar epithelium

    Tall, column-like cells, often found in areas of secretion and absorption.

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    Ciliated columnar epithelium

    Columnar cells with tiny hair-like structures to move substances.

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    Glandular columnar epithelium

    Columnar epithelial cells that produce secretions.

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    Hypoxia

    A deficiency of oxygen that leads to cellular injury.

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    Cellular injury

    Occurs when cells are stressed beyond their ability to adapt.

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    Study Notes

    Histopathology & Cytology Techniques

    • Histopathology is the analysis of cell and tissue shapes, sizes, and architectural patterns within a clinical context.
    • Activities include pre-analytical (e.g., sample collection, transport), analytical (tissue processing, slide reading) and post-analytical (report delivery, archiving).

    Risk Management

    • Risk management ensures environmental and personal health and safety.
    • The first step is identifying risks (electrical, mechanical, biological etc.).
    • Inventory of chemical reagents and proper disposal of obsolete chemicals are essential.

    Laboratory Safety and Instrumentation

    • Understanding hazards (chemicals) is critical.
    • Chemical labels should contain the chemical name, manufacturer's details, date of purchase/creation, expiry date, and safety procedures.
    • Types of hazards include irritants (reversible skin effects), corrosives (irreversible tissue damage), and sensitizers (allergic reactions).
    • Carcinogens can cause tumors (chloroforms, chromic acid, formaldehyde, nickel chloride, potassium dichromate, carcinogenic dyes).
    • Toxic materials are hazardous at certain concentrations (methanol, mercury, chromic acid, osmium tetroxide, uranium nitrate).
    • Physical hazards include falls and poor ergonomics.
    • Biological hazards include infection agents and toxins.
    • Also, Allergens (mold and fungi) can trigger allergic reactions.

    Microscope

    • Microscopes are used by pathologists and histotechnologists.
    • Pathologists examine slides for disease processes.
    • Histotechnologists use microscopy for quality control.
    • Microscopes must magnify, resolve, and visualize.
    • Compound microscopes have different parts (ocular, body tube, coarse focus, objective lens, stage, condenser, etc.).
    • Magnification is determined by objective lens and eyepiece.
    • Different types of microscopes (brightfield, darkfield, phase contrast, fluorescence, polarized, electron) serve specific purposes.
    • Electron microscopes (TEM and SEM) provide greater resolution for internal and surface viewing respectively.

    Laboratory Quality Management System

    • The degree to which healthcare services strive to meet pre-defined outcomes.
    • Safety practices identify and mitigate risks (chemicals, biohazards, mechanical, electrical, fire).
    • Quality Control ensures data integrity and accuracy.
    • Quality Assurance involves assessing and improving various systems within the laboratory.
    • A distributive system uses multiple laboratories for quality assessment.

    Pathology

    • The study of diseases at various levels (cellular abnormalities, tissue, organ, whole body, functional changes).
    • Two main branches: General pathology (basic reactions of tissues) and Systemic pathology (specific responses in organs).
    • Branches include Autopsy (study of macroscopic and microscopic tissue using cadavers), Gross Pathology (visual analysis), and Exfoliative cytology (microscopic study of desquamated cells).

    Cellular Injury and Cell Death

    • Cellular injury occurs when cells undergo stress that they are unable to adapt to.
    • This may be due to external or internal factors.
    • Cell death can be reversible or irreversible.
    • Irreversible cell death can take place as Necrosis (unregulated cell death) or Apoptosis (programmed cell death).
    • Different types of necrosis occur, including coagulative, liquefactive, gangrenous, and caseous.
    • Cell death is a pivotal aspect of disease processes.

    Techniques (Biopsy & Autopsy)

    • Biopsy is the removal of tissue samples from a living patient for examination.
    • Types of biopsy include excisional, incisional/core, fine needle aspiration, punch, and shave.
    • Autopsy (also called necropsy) is the examination of a deceased body.
    • Autopsy aims at determining if and where injury or disease occurred, and or the manner/cause of death.
    • Both procedures are vital for diagnosis and clinical research.

    Tissue Healing and Repair

    • Tissue repair is a complex process.
    • Repair involves regeneration (replacement with identical tissue) or scar formation (replacement with connective tissue).
    • This process is affected by inflammatory response, blood supply, tissue type, and the presence of foreign substances.

    Cellular Adaptations

    • Cell adjustments to their environment include Atrophy (loss of cell size), Hypertrophy (increase in cell size), Hyperplasia (increase in cell numbers), Dysplasia (change in cell shape/size/arrangement), or Metaplasia (change in cell type).

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    Description

    Test your knowledge on cell injury, epithelial functions, and the principles of surgical pathology. This quiz covers major concepts in cellular changes during reversible injury and the characteristics of different types of epithelium. Challenge yourself to see how well you understand these critical biological processes.

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