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Questions and Answers
What is a possible consequence of a high lipid diet, according to the text?
What is a possible consequence of a high lipid diet, according to the text?
What is a common morphological change observed in cells undergoing reversible injury?
What is a common morphological change observed in cells undergoing reversible injury?
Which of the following is NOT a cellular change associated with mitochondrial alterations during reversible injury?
Which of the following is NOT a cellular change associated with mitochondrial alterations during reversible injury?
What is the main difference between reversible cell injury and cell death?
What is the main difference between reversible cell injury and cell death?
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What is a possible cause of nutritional imbalances leading to cellular injury?
What is a possible cause of nutritional imbalances leading to cellular injury?
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What is the primary function of columnar epithelium?
What is the primary function of columnar epithelium?
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Which of the following is NOT a characteristic of cuboidal epithelium?
Which of the following is NOT a characteristic of cuboidal epithelium?
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What is the name of the condition where there is a deficiency of oxygen?
What is the name of the condition where there is a deficiency of oxygen?
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Which type of epithelium is characterized by cells being taller than they are wide?
Which type of epithelium is characterized by cells being taller than they are wide?
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What is the function of the nervous system?
What is the function of the nervous system?
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What is the primary focus of surgical pathology?
What is the primary focus of surgical pathology?
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Which of the following is NOT a branch of anatomic pathology?
Which of the following is NOT a branch of anatomic pathology?
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Which of the following is NOT a category of injurious stimuli mentioned in the text?
Which of the following is NOT a category of injurious stimuli mentioned in the text?
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What is the main purpose of studying biopsy specimens in anatomic pathology?
What is the main purpose of studying biopsy specimens in anatomic pathology?
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What is the difference between a postmortem examination and a surgical pathology examination?
What is the difference between a postmortem examination and a surgical pathology examination?
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Which of the following is another term for hypoxia?
Which of the following is another term for hypoxia?
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How does the study of tissue histology contribute to the understanding of diseases?
How does the study of tissue histology contribute to the understanding of diseases?
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Which of the following is a benefit of analyzing specific markers in patients?
Which of the following is a benefit of analyzing specific markers in patients?
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How does anatomic pathology contribute to the field of transplantation?
How does anatomic pathology contribute to the field of transplantation?
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What is the primary focus of the 'Clinical immunology and serology' branch of pathology?
What is the primary focus of the 'Clinical immunology and serology' branch of pathology?
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What is the primary goal of quality assurance programs in laboratories?
What is the primary goal of quality assurance programs in laboratories?
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Which organization is NOT mentioned as providing data for quality assessment programs?
Which organization is NOT mentioned as providing data for quality assessment programs?
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How does the Quality Control (QC) data function in relation to Quality Assurance (QA)?
How does the Quality Control (QC) data function in relation to Quality Assurance (QA)?
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What does NEQAS stand for?
What does NEQAS stand for?
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What opportunity does continuing quality improvement focus on in laboratory systems?
What opportunity does continuing quality improvement focus on in laboratory systems?
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What is the primary function of the objective lens in a compound microscope?
What is the primary function of the objective lens in a compound microscope?
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Which component of the microscope allows the adjustment of light intensity on the slide?
Which component of the microscope allows the adjustment of light intensity on the slide?
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How does resolution in microscopy generally defined?
How does resolution in microscopy generally defined?
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What is the disadvantage of using a monocular microscope compared to other types?
What is the disadvantage of using a monocular microscope compared to other types?
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Which part of the microscope provides the means to focus the image in a coarse manner?
Which part of the microscope provides the means to focus the image in a coarse manner?
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What does the stage of a microscope typically enable?
What does the stage of a microscope typically enable?
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Which component is used to change the size of the beam of light coming through the stage?
Which component is used to change the size of the beam of light coming through the stage?
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What characteristic of a microscope enables it to display details of an object clearly?
What characteristic of a microscope enables it to display details of an object clearly?
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What does the term 'pathogenesis' refer to?
What does the term 'pathogenesis' refer to?
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Which of the following roles is a pathologist primarily responsible for?
Which of the following roles is a pathologist primarily responsible for?
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According to Rudolf Virchow, where do all diseases originate?
According to Rudolf Virchow, where do all diseases originate?
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What is the primary focus of the study of pathology?
What is the primary focus of the study of pathology?
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Which branch of medical science is primarily concerned with the examination of surgically removed organs and tissues?
Which branch of medical science is primarily concerned with the examination of surgically removed organs and tissues?
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What characterizes a selective system in the context of histopathologic preparations?
What characterizes a selective system in the context of histopathologic preparations?
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Which term best describes the study of cellular abnormalities associated with diseases?
Which term best describes the study of cellular abnormalities associated with diseases?
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In pathology, which of the following is least likely to be examined?
In pathology, which of the following is least likely to be examined?
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Flashcards
Magnification
Magnification
The process of enlarging the appearance of an object without increasing its size.
Resolution
Resolution
The shortest distance between two points that can still be distinguished as separate.
Resolving Power
Resolving Power
Ability of the microscope to distinguish between small objects that are close together.
Ocular (Eyepiece)
Ocular (Eyepiece)
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Coarse Focusing Knob
Coarse Focusing Knob
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Objective Lens
Objective Lens
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Condenser Lenses
Condenser Lenses
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Field (Iris) Diaphragm
Field (Iris) Diaphragm
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Quality Control (QC)
Quality Control (QC)
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Quality Assurance (QA)
Quality Assurance (QA)
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College of American Pathologists (CAP)
College of American Pathologists (CAP)
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UK NEQAS
UK NEQAS
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Continuous Quality Improvement (CQI)
Continuous Quality Improvement (CQI)
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Pathology
Pathology
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Pathogenesis
Pathogenesis
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Pathobiology
Pathobiology
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Pathologist
Pathologist
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Histopathology
Histopathology
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Biopsy
Biopsy
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Autopsy
Autopsy
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Cellular abnormalities
Cellular abnormalities
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Anatomic Pathology
Anatomic Pathology
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Surgical Pathology
Surgical Pathology
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Branches of Clinical Pathology
Branches of Clinical Pathology
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Blood Banking
Blood Banking
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Hematology
Hematology
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Clinical Chemistry
Clinical Chemistry
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Clinical Immunology
Clinical Immunology
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Microbiology
Microbiology
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Blunting
Blunting
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Mitochondrial Changes
Mitochondrial Changes
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Cell Death
Cell Death
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Reversible Cell Injury
Reversible Cell Injury
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Atherosclerosis
Atherosclerosis
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Nerve impulse propagation
Nerve impulse propagation
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Squamous epithelium
Squamous epithelium
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Cuboidal epithelium
Cuboidal epithelium
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Columnar epithelium
Columnar epithelium
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Ciliated columnar epithelium
Ciliated columnar epithelium
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Glandular columnar epithelium
Glandular columnar epithelium
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Hypoxia
Hypoxia
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Cellular injury
Cellular injury
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Study Notes
Histopathology & Cytology Techniques
- Histopathology is the analysis of cell and tissue shapes, sizes, and architectural patterns within a clinical context.
- Activities include pre-analytical (e.g., sample collection, transport), analytical (tissue processing, slide reading) and post-analytical (report delivery, archiving).
Risk Management
- Risk management ensures environmental and personal health and safety.
- The first step is identifying risks (electrical, mechanical, biological etc.).
- Inventory of chemical reagents and proper disposal of obsolete chemicals are essential.
Laboratory Safety and Instrumentation
- Understanding hazards (chemicals) is critical.
- Chemical labels should contain the chemical name, manufacturer's details, date of purchase/creation, expiry date, and safety procedures.
- Types of hazards include irritants (reversible skin effects), corrosives (irreversible tissue damage), and sensitizers (allergic reactions).
- Carcinogens can cause tumors (chloroforms, chromic acid, formaldehyde, nickel chloride, potassium dichromate, carcinogenic dyes).
- Toxic materials are hazardous at certain concentrations (methanol, mercury, chromic acid, osmium tetroxide, uranium nitrate).
- Physical hazards include falls and poor ergonomics.
- Biological hazards include infection agents and toxins.
- Also, Allergens (mold and fungi) can trigger allergic reactions.
Microscope
- Microscopes are used by pathologists and histotechnologists.
- Pathologists examine slides for disease processes.
- Histotechnologists use microscopy for quality control.
- Microscopes must magnify, resolve, and visualize.
- Compound microscopes have different parts (ocular, body tube, coarse focus, objective lens, stage, condenser, etc.).
- Magnification is determined by objective lens and eyepiece.
- Different types of microscopes (brightfield, darkfield, phase contrast, fluorescence, polarized, electron) serve specific purposes.
- Electron microscopes (TEM and SEM) provide greater resolution for internal and surface viewing respectively.
Laboratory Quality Management System
- The degree to which healthcare services strive to meet pre-defined outcomes.
- Safety practices identify and mitigate risks (chemicals, biohazards, mechanical, electrical, fire).
- Quality Control ensures data integrity and accuracy.
- Quality Assurance involves assessing and improving various systems within the laboratory.
- A distributive system uses multiple laboratories for quality assessment.
Pathology
- The study of diseases at various levels (cellular abnormalities, tissue, organ, whole body, functional changes).
- Two main branches: General pathology (basic reactions of tissues) and Systemic pathology (specific responses in organs).
- Branches include Autopsy (study of macroscopic and microscopic tissue using cadavers), Gross Pathology (visual analysis), and Exfoliative cytology (microscopic study of desquamated cells).
Cellular Injury and Cell Death
- Cellular injury occurs when cells undergo stress that they are unable to adapt to.
- This may be due to external or internal factors.
- Cell death can be reversible or irreversible.
- Irreversible cell death can take place as Necrosis (unregulated cell death) or Apoptosis (programmed cell death).
- Different types of necrosis occur, including coagulative, liquefactive, gangrenous, and caseous.
- Cell death is a pivotal aspect of disease processes.
Techniques (Biopsy & Autopsy)
- Biopsy is the removal of tissue samples from a living patient for examination.
- Types of biopsy include excisional, incisional/core, fine needle aspiration, punch, and shave.
- Autopsy (also called necropsy) is the examination of a deceased body.
- Autopsy aims at determining if and where injury or disease occurred, and or the manner/cause of death.
- Both procedures are vital for diagnosis and clinical research.
Tissue Healing and Repair
- Tissue repair is a complex process.
- Repair involves regeneration (replacement with identical tissue) or scar formation (replacement with connective tissue).
- This process is affected by inflammatory response, blood supply, tissue type, and the presence of foreign substances.
Cellular Adaptations
- Cell adjustments to their environment include Atrophy (loss of cell size), Hypertrophy (increase in cell size), Hyperplasia (increase in cell numbers), Dysplasia (change in cell shape/size/arrangement), or Metaplasia (change in cell type).
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Description
Test your knowledge on cell injury, epithelial functions, and the principles of surgical pathology. This quiz covers major concepts in cellular changes during reversible injury and the characteristics of different types of epithelium. Challenge yourself to see how well you understand these critical biological processes.