Podcast
Questions and Answers
What is the main function of the endoplasmic reticulum (ER) in an animal cell?
What is the main function of the endoplasmic reticulum (ER) in an animal cell?
- Energy production and storage
- DNA replication and repair
- Protein modification and quality control (correct)
- Lipid degradation and recycling
Which structure within the ER plays a key role in transferring preformed precursor oligosaccharides to proteins?
Which structure within the ER plays a key role in transferring preformed precursor oligosaccharides to proteins?
- Calreticulin
- Membrane-bound oligosaccharide transferase (correct)
- Chaperon proteins
- Calnexin
What is the role of N-glycosylation in the ER related to protein folding?
What is the role of N-glycosylation in the ER related to protein folding?
- Promoting protein degradation
- Regulating lipid biosynthesis
- Initiating protein synthesis
- Preventing folding intermediates from aggregating (correct)
Which proteins in the ER bind to oligosaccharides on folding intermediates to help with correct protein folding?
Which proteins in the ER bind to oligosaccharides on folding intermediates to help with correct protein folding?
What distinguishes folding intermediates from mis-folded proteins in the ER during protein processing?
What distinguishes folding intermediates from mis-folded proteins in the ER during protein processing?
Which process in the ER involves the covalent addition of oligosaccharides to proteins?
Which process in the ER involves the covalent addition of oligosaccharides to proteins?
What is the significance of trimming a mannose on the core Nglycan of a protein?
What is the significance of trimming a mannose on the core Nglycan of a protein?
Why do proteins that fold and exit the ER faster than mannose trimming occur avoid degradation?
Why do proteins that fold and exit the ER faster than mannose trimming occur avoid degradation?
What role do Glucosyltransferases play in the ER quality control process?
What role do Glucosyltransferases play in the ER quality control process?
What is the main function of calnexin and calreticulin in recognizing N-linked glycans?
What is the main function of calnexin and calreticulin in recognizing N-linked glycans?
How does the unfolded protein response (UPR) get triggered in the ER?
How does the unfolded protein response (UPR) get triggered in the ER?
What is the role of PERK in the unfolded protein response (UPR)?
What is the role of PERK in the unfolded protein response (UPR)?
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