Midterm quiz
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Questions and Answers

Itraconazole inhibits:

  • Chromosome D450
  • Cytochrome F150 XLT
  • Cytochrome P450 3A4 (correct)
  • Cytoplasm P450 3A4

CYP3A4 is an _____ that metabolizes many drugs and other foreign substances in the body.

Enzyme

Women tend to have higher CYP3A4 activity than men.

True (A)

As itraconazole inhibits CYP3A4, this ultimately does what to the levels of many other drugs?

<p>Increases levels (B)</p> Signup and view all the answers

Examples of drugs affected by CYP3A4 include (select all that apply)

<p>Quinidine (A), Pimozide (B), Dofetilide (C), Ciaspride (D)</p> Signup and view all the answers

Caspofungin is an

<p>Antifungal (B)</p> Signup and view all the answers

Two main fungal species treated by Caspofungin include

<p>Candida (B), Aspergillus (C)</p> Signup and view all the answers

Adverse effects of Caspofungin include

<p>Nausea and vomiting (A), Fever (B), Phlebitis at injection site (C), Headache (D)</p> Signup and view all the answers

Flashcards

What is a CYP3A4?

A protein that helps break down substances in the body.

What is Caspofungin?

An antifungal medication that blocks a specific enzyme needed by some fungi to form their cell walls.

How does Itraconazole work?

Itraconazole, a drug, binds to and prevents CYP3A4 from working.

How is CYP3A4 activity different in women and men?

Higher CYP3A4 activity means the body breaks down drugs faster.

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What is the consequence of inhibiting CYP3A4?

Inhibiting CYP3A4 can cause other drugs to build up in the body.

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Why is CYP3A4 important?

CYP3A4 is the main enzyme responsible for breaking down many drugs and foreign substances.

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What happens when the levels of drugs increase?

High levels of drugs can lead to side effects and toxicity.

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Which fungal species are treated by Caspofungin?

Candida and Aspergillus are two types of fungi that Caspofungin can treat.

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