Podcast
Questions and Answers
Which of the following is a potential source of endogenous DNA damage?
Which of the following is a potential source of endogenous DNA damage?
- Organic compounds
- Superoxide (O2-) (correct)
- UV radiation
- Inorganic compounds
What type of damage can UV-C radiation cause to DNA?
What type of damage can UV-C radiation cause to DNA?
- Relatively harmless to DNA
- The most severe DNA damage (correct)
- Does not impact DNA replication
- Primarily absorbed by the DNA
Which type of radiation contains high energy and impacts DNA more?
Which type of radiation contains high energy and impacts DNA more?
- UV-C (correct)
- Hydrogen peroxide (H2O2)
- UV-A
- UV-B
What is the consequence of reactive oxygen species on DNA replication?
What is the consequence of reactive oxygen species on DNA replication?
What is the result of hydrolytic depurination on DNA?
What is the result of hydrolytic depurination on DNA?
Which of the following is a potential source of exogenous DNA damage?
Which of the following is a potential source of exogenous DNA damage?
What can ammonia removal from bases in DNA result in?
What can ammonia removal from bases in DNA result in?
What type of DNA damage is caused by alkylating agents?
What type of DNA damage is caused by alkylating agents?
Which type of mutation results in a change of a single base pair?
Which type of mutation results in a change of a single base pair?
What is the primary function of DNA ligase in DNA repair?
What is the primary function of DNA ligase in DNA repair?
Which enzyme reverses methylation of guanine bases?
Which enzyme reverses methylation of guanine bases?
What is the consequence of a nonsense mutation?
What is the consequence of a nonsense mutation?
What is the primary role of alkylating agents on DNA?
What is the primary role of alkylating agents on DNA?
What is the function of excision nuclease in nucleotide excision repair?
What is the function of excision nuclease in nucleotide excision repair?
How does base excision repair recognize altered bases in DNA?
How does base excision repair recognize altered bases in DNA?
Alkylating agents transfer alkyl groups such as methyl and ethyl onto nitrogen and oxygen atoms in DNA.
Alkylating agents transfer alkyl groups such as methyl and ethyl onto nitrogen and oxygen atoms in DNA.
Crosslinking of DNA strands by cisplatin inhibits transcription, translation, and can kill a cell.
Crosslinking of DNA strands by cisplatin inhibits transcription, translation, and can kill a cell.
DNA glycosylases scan DNA for altered bases and hydrolyze the sugar-base bond of damaged nucleotides.
DNA glycosylases scan DNA for altered bases and hydrolyze the sugar-base bond of damaged nucleotides.
Methyl guanine methyl transferase (MGMT) reverses methylation of guanine bases in DNA.
Methyl guanine methyl transferase (MGMT) reverses methylation of guanine bases in DNA.
Photolyase is an example of an enzyme that can directly reverse some DNA damages, such as pyrimidine dimers.
Photolyase is an example of an enzyme that can directly reverse some DNA damages, such as pyrimidine dimers.
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