Cataract and Its Causes
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Questions and Answers

What is a cataract and how does it affect vision?

A cataract is a light-scattering opacity within the lens that can lead to visual loss when it obstructs the visual axis.

Identify two environmental factors that may contribute to the development of age-related cataracts.

Cumulative exposure to UV radiation and smoking are two environmental factors contributing to age-related cataracts.

Explain the impact of ocular trauma on cataract formation.

Ocular trauma, including blunt and penetrating injuries, can lead to the development of cataracts by causing direct damage to the lens.

What role do systemic diseases play in cataract development?

<p>Systemic diseases can contribute to cataract formation through various pathways, potentially exacerbating the effects of aging and environmental factors.</p> Signup and view all the answers

How does uveitis potentially lead to cataract formation?

<p>Uveitis can lead to unilateral cataract formation if it affects one eye, causing inflammation that impacts the lens.</p> Signup and view all the answers

What effect does near vision have on pupil size and how does this relate to cataract vision obstruction?

<p>Near vision causes miosis, which reduces pupil diameter and creates more obstruction from the cataract, leading to poorer vision.</p> Signup and view all the answers

Differentiate between immature and mature cataracts.

<p>An immature cataract is partially opaque, while a mature cataract is completely opaque.</p> Signup and view all the answers

What characterizes a hypermature cataract?

<p>A hypermature cataract has a shrunken and wrinkled anterior capsule due to water leakage from the lens.</p> Signup and view all the answers

What symptoms are commonly associated with cataracts?

<p>Common symptoms include painless loss of vision, glare from light scattering, and changes in refraction.</p> Signup and view all the answers

Explain the significance of signs found during an eye examination for cataracts.

<p>Cataracts appear as a dark silhouette against the red reflex, aiding in diagnosis and determining the need for surgery.</p> Signup and view all the answers

What is one primary indication for cataract surgery?

<p>The primary indication for cataract surgery is visual improvement when daily activities are impacted by visibility loss.</p> Signup and view all the answers

Describe the visual impact of a nuclear cataract.

<p>A nuclear cataract may cause a myopic shift, leading to nearsightedness and difficulty with distance vision.</p> Signup and view all the answers

What is a Morgagnian cataract, and how does it differ from a hypermature cataract?

<p>A Morgagnian cataract is a type of hypermature cataract where liquefaction allows the nucleus to sink inferiorly.</p> Signup and view all the answers

What constitutes a medical indication for cataract surgery?

<p>Medical indications arise when a cataract adversely affects eye health, such as causing phacolytic or phacomorphic glaucoma.</p> Signup and view all the answers

Why is fundus examination significant in the context of cataract surgery?

<p>Fundus examination helps monitor or treat conditions like diabetic retinopathy, which may require improved clarity provided by cataract surgery.</p> Signup and view all the answers

What does a cover test in ophthalmic preoperative assessment reveal?

<p>A cover test may indicate heterotropia, suggesting amblyopia or a risk of diplopia if vision is improved.</p> Signup and view all the answers

What preoperative conditions of the ocular adnexa may necessitate resolution before cataract surgery?

<p>Conditions like dacryocystitis, blepharitis, and chronic conjunctivitis must be resolved to prevent endophthalmitis.</p> Signup and view all the answers

How does corneal health impact cataract surgery outcomes?

<p>Eyes with decreased endothelial cell counts are at higher risk of postoperative decompensation due to surgical trauma.</p> Signup and view all the answers

What challenges can arise from a shallow anterior chamber before cataract surgery?

<p>A shallow anterior chamber can lead to difficulties in creating a capsulorrhexis and may require additional mydriatic measures.</p> Signup and view all the answers

How do different types of cataracts affect the phacoemulsification process?

<p>Nuclear cataracts are harder and may need more power for phacoemulsification, whereas cortical opacities are generally softer.</p> Signup and view all the answers

In assessing current refractive status, what is the primary purpose before cataract surgery?

<p>Assessing current refractive status guides the selection of an appropriate intraocular lens (IOL) implant.</p> Signup and view all the answers

What is a Vossius ring and what does it indicate?

<p>A Vossius ring is an imprint of iris pigment on the lens that results from blunt trauma and indicates a traumatic cataract.</p> Signup and view all the answers

Name two systemic drugs that can lead to posterior subcapsular cataracts.

<p>Systemic steroids and chlorpromazine can lead to posterior subcapsular cataracts.</p> Signup and view all the answers

How does chronic anterior uveitis contribute to cataract formation?

<p>Chronic anterior uveitis can lead to the development of cataracts due to persistent inflammation affecting the lens.</p> Signup and view all the answers

What systemic cause of cataract is associated with congenital rubella?

<p>Congenital rubella infection is a systemic cause of cataract.</p> Signup and view all the answers

Describe the characteristic change seen in nuclear cataracts.

<p>Nuclear cataracts begin as an exaggeration of normal aging changes in the lens nucleus and often increase the refractive index.</p> Signup and view all the answers

What are glaukomflecken and in what context do they occur?

<p>Glaukomflecken are anterior subcapsular opacities that occur due to acute angle-closure glaucoma.</p> Signup and view all the answers

Identify one syndrome associated with cataract formation.

<p>Down syndrome is one of the syndromes associated with cataract formation.</p> Signup and view all the answers

How do metabolic disorders contribute to cataract formation?

<p>Metabolic disorders such as galactosaemia and hypocalcaemia can cause lens opacities leading to cataracts.</p> Signup and view all the answers

What are the potential consequences of congenital cataract on a child's vision?

<p>Congenital cataract can lead to bilateral amblyopia, squint, and nystagmus due to impaired retinal image formation during visual development.</p> Signup and view all the answers

Why is urgent surgery recommended for congenital cataract within the first few weeks of life?

<p>Urgent surgery is necessary to maximize the chances of successful visual development and to prevent amblyopia and other complications.</p> Signup and view all the answers

What role do contact lenses play in the treatment of aphakia in infants?

<p>Contact lenses correct aphakia but require substantial input and motivation from the child's parents to be effective.</p> Signup and view all the answers

How might cataract surgery in infants before one year of age pose a risk for glaucoma?

<p>Surgery performed prior to one year of age carries a significant risk of developing subsequent glaucoma.</p> Signup and view all the answers

What is the difference between subluxation and dislocation of the lens in ectopia lentis?

<p>Subluxation refers to a minor displacement of the lens, while dislocation indicates a more advanced or complete displacement.</p> Signup and view all the answers

What are some inherited disorders associated with ectopia lentis?

<p>Inherited disorders like homocystinuria and Marfan syndrome can cause ectopia lentis due to defects in zonular proteins.</p> Signup and view all the answers

Why do problems with lens shape and position contribute to myopia?

<p>Abnormal lens shape and ectopia lentis can cause the eye to become more rounded, resulting in increased myopia.</p> Signup and view all the answers

What treatment methods are increasingly used for children over 2 years old with congenital cataracts?

<p>Intraocular lenses are implanted, along with coordinated patching routines for the amblyopic eye.</p> Signup and view all the answers

What is the significance of keratometry readings in refractive surgery planning?

<p>Keratometry readings are crucial for assessing the curvature of the anterior corneal surface, particularly for addressing astigmatism through targeted wound placement or adjunctive procedures.</p> Signup and view all the answers

How does biometry assist in determining the power of intraocular lenses (IOL)?

<p>Biometry aids in calculating the lens power needed for the desired refractive outcome by measuring keratometry and axial length.</p> Signup and view all the answers

What is a common formula used for IOL power calculation, specifically for eyes with axial lengths greater than 22.0 mm?

<p>The SRK-T formula is commonly used for calculating IOL power in eyes with axial lengths greater than 22.0 mm.</p> Signup and view all the answers

Why is it necessary for patients to refrain from wearing contact lenses before undergoing biometry?

<p>Patients need to stop wearing contact lenses to allow for corneal stabilization, ensuring accurate measurements during biometry.</p> Signup and view all the answers

What technology is commonly used for non-contact axial measurements in biometry?

<p>Optical coherence biometry utilizes low-energy laser beams for non-contact axial measurements.</p> Signup and view all the answers

What factors influence the choice of IOL power during cataract surgery planning?

<p>The choice of IOL power is influenced by the refraction of the fellow eye and whether that eye also has a cataract requiring surgery.</p> Signup and view all the answers

Explain the role of the Zeiss IOLMaster in preoperative assessments.

<p>The Zeiss IOLMaster performs comprehensive biometry, measuring keratometry, anterior chamber depth, and calculating IOL power using various formulae.</p> Signup and view all the answers

What is the importance of analyzing postoperative refractive results in previously operated eyes?

<p>Analyzing postoperative refractive results helps identify any 'refractive surprises' and adjust future surgical strategies accordingly.</p> Signup and view all the answers

What is the initial appearance of nuclear sclerosis and how does it relate to presbyopia?

<p>Nuclear sclerosis initially appears with a yellowish hue due to urochrome pigment deposition, which can counteract presbyopia, potentially reducing the need for magnifying glasses.</p> Signup and view all the answers

Describe the progression of cortical cataracts and the visual symptoms they typically cause.

<p>Cortical cataracts initially develop as vacuoles and clefts in the lens cortex, progressing to radial spoke-like opacities that commonly cause glare due to light scattering.</p> Signup and view all the answers

How do posterior subcapsular cataracts differ from nuclear and cortical cataracts in terms of vision impairment?

<p>Posterior subcapsular cataracts are located at the nodal point of the eye, leading to greater impairment of near vision compared to distance vision, unlike nuclear or cortical cataracts.</p> Signup and view all the answers

What morphological changes occur in the lens during the development of nuclear cataracts?

<p>Nuclear cataracts progress from yellow to brown due to increasing nuclear opacification and exaggeration of normal aging changes.</p> Signup and view all the answers

What specific changes are involved in the formation of anterior subcapsular cataracts?

<p>Anterior subcapsular cataracts are characterized by fibrous metaplasia of the lens epithelium, which occurs directly under the lens capsule.</p> Signup and view all the answers

How does spherical aberration affect vision in relation to lens function?

<p>Spherical aberration occurs when the outer parts of a lens do not focus light rays at the same point as the central part, leading to blurred vision.</p> Signup and view all the answers

In cataract progression, what is the significance of the 'clefts and vacuoles' observed in cortical cataracts?

<p>The initial appearance of clefts and vacuoles in cortical cataracts indicates early hydration changes in lens fibers, which can lead to vision complications.</p> Signup and view all the answers

Explain the relationship between aging, nuclear sclerosis, and the concept of 'second sight.'

<p>As individuals age, nuclear sclerosis can induce a temporary restoration of near vision, known as 'second sight,' despite its eventual progression to cataracts.</p> Signup and view all the answers

What causes the formation of a Vossius ring in the context of ocular trauma?

<p>A Vossius ring is caused by the imprinting of iris pigment onto the anterior lens capsule, usually due to blunt trauma or concussion.</p> Signup and view all the answers

Which drugs are commonly associated with posterior subcapsular cataract formation?

<p>Drugs such as systemic or topical steroids and chlorpromazine are commonly associated with posterior subcapsular cataracts.</p> Signup and view all the answers

Explain the term 'glaukomflecken' and its clinical significance.

<p>Glaukomflecken are opacities on the anterior lens capsule that result from ischemic damage during acute angle-closure glaucoma.</p> Signup and view all the answers

What is the relationship between nuclear cataract and myopia?

<p>Nuclear cataract can lead to myopia due to an increase in the refractive index of the lens nucleus, causing changes in light refraction.</p> Signup and view all the answers

Identify a syndrome associated with congenital cataract and explain its significance.

<p>Down syndrome is associated with congenital cataract, which can lead to significant visual impairment if not addressed early.</p> Signup and view all the answers

Discuss how metabolic disorders contribute to cataract formation.

<p>Metabolic disorders like galactosaemia and hypocalcaemia disrupt lens metabolism, leading to opacification and cataract development.</p> Signup and view all the answers

What is the main surgical approach for cataract removal and how is it usually performed?

<p>The main surgical approach is phacoemulsification, where an ultrasound probe is used to emulsify the lens through a small incision.</p> Signup and view all the answers

How does chronic anterior uveitis increase the risk of cataract formation?

<p>Chronic anterior uveitis can cause prolonged inflammation, leading to complications such as cataract formation due to abnormal healing.</p> Signup and view all the answers

What is the impact of ionizing radiation on cataract formation?

<p>Ionizing radiation can cause direct damage to the lens fibers, resulting in cataract formation over time.</p> Signup and view all the answers

Prior to cataract surgery, what important information must be conveyed to patients regarding coexisting conditions?

<p>Patients must be informed about any coexisting eye disease that may affect the outcomes of cataract surgery and the visual prognosis.</p> Signup and view all the answers

What potential visual symptoms indicate the need for cataract surgery?

<p>Potential symptoms include difficulty recognizing faces, reading, and experiencing significant glare.</p> Signup and view all the answers

What is the significance of using a toric intraocular lens in cataract surgery?

<p>A toric intraocular lens is significant because it incorporates astigmatic correction, improving visual outcomes for patients with astigmatism.</p> Signup and view all the answers

Describe the role of local anesthesia in cataract surgery.

<p>Local anesthesia is used to numb the eye area, allowing surgery to be performed while the patient remains awake.</p> Signup and view all the answers

What innovations are currently being explored in cataract surgery techniques?

<p>Innovations include the use of femtosecond lasers for making incisions and partially emulsifying the lens.</p> Signup and view all the answers

Why is it important for younger patients to understand the adjustment time after cataract surgery?

<p>Younger patients need to know they may experience sudden loss of active focusing, requiring an adjustment period.</p> Signup and view all the answers

What is the role of the plastic lens implant after cataract surgery?

<p>The plastic lens implant restores focusing ability, replacing the natural lens that was removed.</p> Signup and view all the answers

What can trigger the onset of squint in infants with bilateral cataracts?

<p>Bilateral amblyopia can trigger the onset of squint.</p> Signup and view all the answers

How does the timing of cataract surgery impact the risk of subsequent glaucoma in infants?

<p>Surgery performed before one year of age significantly increases the risk of developing glaucoma.</p> Signup and view all the answers

Why is a coordinated patching routine essential for children with congenital cataracts?

<p>It is essential to stimulate visual maturation in the amblyopic eye and minimize the risk of squint.</p> Signup and view all the answers

Discuss the relationship between ectopia lentis and myopia.

<p>Ectopia lentis can lead to a more rounded lens shape, resulting in increased myopia.</p> Signup and view all the answers

What complications may arise from the surgery of congenital cataracts in infants?

<p>Complications include risks of developing glaucoma and potential issues with visual maturation.</p> Signup and view all the answers

How does homocystinuria relate to lens position abnormalities?

<p>Homocystinuria is associated with ectopia lentis, causing downward displacement of the lens.</p> Signup and view all the answers

In the context of congenital cataracts, why is fitting contact lenses a significant challenge for parents?

<p>It requires considerable input and motivation from the parents to ensure effective treatment for aphakia.</p> Signup and view all the answers

What are the characteristics of anterior lenticonus associated with Alport's syndrome?

<p>It is characterized by bilateral, conical anterior protrusion of the anterior lens surface.</p> Signup and view all the answers

Study Notes

Cataract

  • A light-scattering opacity within the lens
  • Can lead to visual loss when it impedes visual axis
  • Most common cause of blindness in the world
  • Majority of cataracts are age related, developing as a consequence of UV exposure, poor diet, chronic disease, smoking etc.
  • Can be caused by specific ocular or systemic disease, some are inherited

Causes of Cataract

  • Ocular Trauma
    • Penetrating injury
    • Blunt trauma to the globe
    • Ionizing radiation
    • Infrared radiation
    • Electrical shock
  • Uveitis
    • Unilateral if affecting only one eye
  • High Myopia
  • Topical Medications
    • Steroid eye drops
  • Intraocular Tumor
    • Ciliary body tumors can physically affect the lens
  • Acute Angle-Closure Glaucoma
    • Glaukomflecken on anterior capsule
  • Concussion
    • Vossius' ring from imprinting of iris pigment
  • Penetrating
    • Flower-shaped
  • Other Causes
    • Ionizing radiation
    • Electric shock
    • Lightning
  • Drugs
    • Systemic or Topical steroids
    • Posterior subcapsular
    • Chlorpromazine
    • Central, anterior capsular granules
    • Other drugs:
      • Long-acting miotics
      • Amiodarone
      • Busulphan
  • Secondary (Complicated) cataract
    • Posterior subcapsular
    • Glaukomflecken
    • Chronic anterior uveitis
    • Follows acute angle-closure glaucoma
  • Systemic Causes
    • Diabetes
    • Metabolic disorders (galactosemia and hypocalcemia)
    • Systemic drugs (steroids, chlorpromazine, Amiodarone)
    • X-radiation
    • Infection (congenital rubella)
    • Atopy (accompanying atopic dermatitis)
    • Inherited (congenital cataracts and some adult cataracts as in myotonic dystrophy, Neurofibromatosis 2)
    • Syndromes (Down syndrome, Lowe syndrome)

Classification According to Location

  • Nuclear Cataract
    • Starts as an exaggeration of the normal aging changes involving the lens nucleus
    • Often associated with myopia due to the increased refractive index of the nucleus, and also with increased spherical aberration
    • May cause patients to be able to read without spectacles again ('second sight of the aged')
  • Subcapsular Cataract
    • Anterior
    • Posterior

Classification According to Maturity

  • Immature Cataract
    • Lens is partially opaque
  • Mature Cataract
    • Lens is completely opaque
  • Hypermature Cataract
    • Anterior capsule is shrunken and wrinkled due to water leakage from the lens
  • Morgagnian Cataract
    • Hypermature cataract in which the nucleus has sunk inferiorly due to liquefaction of the cortex

Signs and Symptoms

  • Symptoms
    • Painless loss of vision
    • Glare due to light scattering
    • Change in refraction (myopic shift with nuclear cataract)
    • In neonates and infants, cataract causes amblyopia (failure of visual maturation)
  • Signs
    • Reduced visual acuity
    • Impaired reading at all distances
    • Reduced ability for night driving due to glare
    • Reduced acuity in bright light
    • Cataract appears as a dark silhouette against the red reflex.

Preoperative Considerations

  • Indications for Surgery
    • Visual improvement: most common indication
    • Medical indications: phacolytic or phacomorphic glaucoma
    • To Facilitate Fundus Examination: required in the context of fundal pathology requiring monitoring or treatment.
  • Ophthalmic Preoperative Assessment
    • Visual Acuity: tested using a Snellen chart
    • Cover Test: can indicate amblyopia or diplopia if vision is improved.
    • Pupillary Responses: presence of pupillary defect suggests additional pathology
    • Ocular Adnexa: Dacryocystitis, blepharitis, chronic conjunctivitis, lagophthalmos, ectropion, entropion and tear film abnormalities can predispose to endophthalmitis
    • Cornea: Eyes with decreased endothelial cell counts are vulnerable to postoperative decompensation.
    • Anterior Chamber: shallow chamber, poorly dilating pupil may require preoperative mydriatic drops.
    • Lens: Nuclear cataracts tend to be harder for phacoemulsification, while cortical opacities tend to be softer. Black nuclear opacities are extremely dense.
    • Fundus Examination: Pathology such as age-related macular degeneration may affect visual outcome.
    • Current Refractive Status: Guides intraocular lens implant (IOL) selection.

Congenital and Infantile Cataracts

  • Threat to sight: immediate obstruction and disturbance to retinal image formation
  • Can lead to amblyopia, squint or nystagmus
  • Requires urgent surgery within the first few weeks of life

Disorders of Lens Shape

  • Abnormal lens shape is very unusual
  • Alport’s syndrome (anterior lenticonus) - bilateral, conical protrusion of the anterior lens surface
  • Posterior lenticonus (non-syndromic, unilateral condition)
  • Abnormal small lens can be associated with short stature and other skeletal abnormalities.

Disorders of Lens Position (Ectopia lentis)

  • Subluxation - minor displacement of the lens caused by weakness of the zonule
  • Dislocation - more significant displacement
  • Homocystinuria - recessive disorder with ectopia lentis (displaced downwards)
  • Marfan Syndrome - displaced lens upwards, defect in the zonular protein (mutation in the fibrillin gene).
  • Ocular trauma can also cause lens displacement

### Traumatic Cataract

  •  Caused by blunt trauma, penetrating trauma, ionizing radiation, electric shock, and lightning.

  •  Blunt trauma can result in a Vossius ring, flower-shaped imprinting of iris pigment onto anterior lens capsule.

Drug-Induced Cataract

  •  Systemic and topical steroids, chlorpromazine, and long-acting miotics can all cause cataracts.

  •  Chlorpromazine can cause central anterior capsular granules.

Secondary (Complicated) Cataract

  •  Posterior subcapsular cataracts commonly follow chronic anterior uveitis and acute angle-closure glaucoma.

Systemic Causes of Cataract

  •  Diabetes, metabolic disorders (galactosemia and hypocalcemia), systemic drugs (steroids, chlorpromazine, Amiodarone), X-radiation, congenital rubella, atopy, and inherited conditions are common systemic causes.

  •  Specific inherited conditions include myotonic dystrophy, Neurofibromatosis 2, Down syndrome, and Lowe syndrome.

Nuclear Cataract

  •  Starts as an exaggeration of normal aging changes involving the lens nucleus.

  •  Often associated with myopia due to increased refractive index of the nucleus.

  •  Can lead to "second sight of the aged" where patients can read without glasses again.

  •  Early stages characterized by a yellowish hue due to urochrome pigment deposition.

  •  Spherical aberration can occur due to the outer parts of the lens not focusing light rays at the same point as the central part.

Cortical Cataract

  •  May affect the anterior, posterior, or equatorial cortex.

  •  Initially appears as clefts and vacuoles between lens fibers due to hydration of the cortex.

  •  Forms typical cuneiform (wedge-shaped) or radial spoke-like opacities, often in the inferonasal quadrant.

  •  Patients often experience glare due to light scattering.

Subcapsular Cataract

  •  Anterior subcapsular cataracts are located directly under the lens capsule and are associated with fibrous metaplasia of the lens epithelium.

  •  Posterior subcapsular opacities lie just in front of the posterior capsule and have a vacuolated, granular, or plaque-like appearance, appearing black on retroillumination.

  •  Often caused by diabetes, steroid use, and uveitis.

  •  Because of its location at the nodal point of the eye, a posterior subcapsular opacity has a more significant impact on vision than a comparable nuclear or cortical cataract.

  •  Near vision is often impaired more than distance vision.

Cataract Surgery

  •  Requires access to the lens through an opening in the anterior lens capsule.

  •  Involves removing most lens fibers and epithelial cells.

  •  Inserts a plastic lens implant of appropriate optical power.

  •  Implant (IOL) is held in place within the capsular bag.

  •  Usually performed under local anesthesia.

  •  Phacoemulsification (phaco) is the preferred method of lens removal, using an ultrasound probe introduced through a small incision at the limbus.

  •  Femtosecond lasers are increasingly used to make incisions in the cornea, anterior capsule, and partially emulsify the lens.

Congenital Cataract

  •  A threat to sight due to the immediate obstruction of vision and disturbance to retinal image formation during visual development.

  •  Leads to impaired visual maturation and amblyopia.

  •  Triggers the onset of squint.

  •  Bilateral cataract can cause bilateral amblyopia, squint, and nystagmus.

  •  Risk of subsequent glaucoma is significant, particularly in infants undergoing surgery before 1 year of age.

  •  Urgent surgery is required within the first few weeks of life to maximize the chances of success.

Disorders of Lens Shape

  •  Abnormal lens shape is unusual.

  •  Anterior lenticonus (bilateral, conical anterior protrusion) can occur in Alport’s syndrome.

  •  Posterior lenticonus (non-syndromic, unilateral condition) can also occur.

  •  An abnormally small lens may be associated with short stature and other skeletal abnormalities.

Disorders of Lens Position (Ectopia Lentis)

  •  Weakness of the zonule causes lens displacement, termed subluxation if minor, or dislocation when more advanced.

  •  The lens takes on a more rounded form, and the eye becomes more myopic.

  •  Caused by ocular trauma, homocystinuria (recessive disorder with lens displaced downwards), Marfan syndrome (lens displaced upwards), and defects in the zonular protein (mutation in the fibrillin gene).

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This quiz covers the essential information about cataracts, including their characteristics and various causes. Learn about how cataracts can lead to visual impairment and the risk factors associated with their development. Test your knowledge on ocular trauma, uveitis, and other contributing factors to cataract formation.

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