Podcast
Questions and Answers
What is the main component of the cartilage in diarthrodial joints?
What is the main component of the cartilage in diarthrodial joints?
- Type 2 collagen (correct)
- Type 4 collagen
- Type 1 collagen
- Type 3 collagen
What is the role of synovium in diarthrodial joints?
What is the role of synovium in diarthrodial joints?
- Provides blood supply to the cartilage
- Lines the joint and secretes synovial fluid (correct)
- Forms the fibrous capsule around the joint
- Produces chondrocytes for cartilage regeneration
Why does hyaline articular cartilage appear radiolucent on X-ray?
Why does hyaline articular cartilage appear radiolucent on X-ray?
- It is non-calcified (correct)
- It is calcified
- It has a thick structure
- It is made up of type 1 collagen
What happens to the bones in a joint when the hyaline articular cartilage is worn out?
What happens to the bones in a joint when the hyaline articular cartilage is worn out?
What is the main source of nutrients for hyaline articular cartilage?
What is the main source of nutrients for hyaline articular cartilage?
Which enzyme targets the type 2 collagen arcade?
Which enzyme targets the type 2 collagen arcade?
In osteoarthritis (OA), which enzyme targets proteoglycans?
In osteoarthritis (OA), which enzyme targets proteoglycans?
What upregulates MMP enzymes in osteoarthritis?
What upregulates MMP enzymes in osteoarthritis?
Which enzyme targets collagen and is considered a collagenase?
Which enzyme targets collagen and is considered a collagenase?
What inhibits the action of MMP enzymes in normal cartilage?
What inhibits the action of MMP enzymes in normal cartilage?
What stimulates cartilage metabolism and synthesis?
What stimulates cartilage metabolism and synthesis?
What is the main function of proteoglycans in cartilage?
What is the main function of proteoglycans in cartilage?
Which component of the proteoglycan is responsible for determining where glycosaminoglycans will be added?
Which component of the proteoglycan is responsible for determining where glycosaminoglycans will be added?
What happens to water content in the articular cartilage during loading and unloading of joints?
What happens to water content in the articular cartilage during loading and unloading of joints?
In what region of the proteoglycan core protein is chondroitin sulfate (CS) located?
In what region of the proteoglycan core protein is chondroitin sulfate (CS) located?
What is the main effect of glycosaminoglycans (GAGs) being negatively charged?
What is the main effect of glycosaminoglycans (GAGs) being negatively charged?
Which statement best describes the role of aggrecans in the cartilage matrix?
Which statement best describes the role of aggrecans in the cartilage matrix?
Why are proteoglycan aggregates described as 'prisoners' in the collagen network?
Why are proteoglycan aggregates described as 'prisoners' in the collagen network?
Which type of GAG chain is enriched in glucosamine?
Which type of GAG chain is enriched in glucosamine?
'Regression to a more fetal type molecule' in osteoarthritis refers to a reversion to which chondroitin sulfate form?
'Regression to a more fetal type molecule' in osteoarthritis refers to a reversion to which chondroitin sulfate form?
'Synovial space' is a region where water is released by _____________ into during loading of joints.
'Synovial space' is a region where water is released by _____________ into during loading of joints.
What is the main function of the type 2 collagen in hyaline articular cartilage?
What is the main function of the type 2 collagen in hyaline articular cartilage?
What is the main role of proteoglycans (PGs) in hyaline articular cartilage?
What is the main role of proteoglycans (PGs) in hyaline articular cartilage?
In osteoarthritis, what happens to the chondrocytes within the lacunae?
In osteoarthritis, what happens to the chondrocytes within the lacunae?
What is the reason behind the deformability of hyaline articular cartilage?
What is the reason behind the deformability of hyaline articular cartilage?
What happens to proteoglycan aggregates when the collagen network is broken down?
What happens to proteoglycan aggregates when the collagen network is broken down?
Which statement correctly describes the role of chondrocytes in osteoarthritis?
Which statement correctly describes the role of chondrocytes in osteoarthritis?
Why is water content vital for the structure of hyaline articular cartilage?
Why is water content vital for the structure of hyaline articular cartilage?
How do proteoglycans in hyaline articular cartilage attract water?
How do proteoglycans in hyaline articular cartilage attract water?
What is the primary role of chondrocytes in normal hyaline articular cartilage?
What is the primary role of chondrocytes in normal hyaline articular cartilage?
Why is it important to have a hook region on proteoglycans (PGs)?
Why is it important to have a hook region on proteoglycans (PGs)?
What is the main structural component of hyaline articular cartilage?
What is the main structural component of hyaline articular cartilage?
What is the primary source of nutrients for chondrocytes in hyaline articular cartilage?
What is the primary source of nutrients for chondrocytes in hyaline articular cartilage?
What maintains the radiolucent appearance of hyaline articular cartilage on X-ray?
What maintains the radiolucent appearance of hyaline articular cartilage on X-ray?
Where do tendons and ligaments attach to bone in the body?
Where do tendons and ligaments attach to bone in the body?
What causes bones to appear to be touching due to the loss of the spacer effect in arthritis?
What causes bones to appear to be touching due to the loss of the spacer effect in arthritis?
What is the function of synovium in diarthrodial joints?
What is the function of synovium in diarthrodial joints?
What happens to the reparative capacity of hyaline articular cartilage once it wears out?
What happens to the reparative capacity of hyaline articular cartilage once it wears out?
What are the two main components of articular cartilage?
What are the two main components of articular cartilage?
How does hyaline articular cartilage obtain its nutrients?
How does hyaline articular cartilage obtain its nutrients?
Why does hyaline articular cartilage look radiolucent on X-ray?
Why does hyaline articular cartilage look radiolucent on X-ray?
What is the main function of the type 2 collagen in hyaline articular cartilage?
What is the main function of the type 2 collagen in hyaline articular cartilage?
What is the primary role of chondrocytes in normal hyaline articular cartilage?
What is the primary role of chondrocytes in normal hyaline articular cartilage?
What are the properties of hyaline articular cartilage?
What are the properties of hyaline articular cartilage?
What is the reason behind the deformability of hyaline articular cartilage?
What is the reason behind the deformability of hyaline articular cartilage?
In osteoarthritis (OA), which enzyme targets proteoglycans?
In osteoarthritis (OA), which enzyme targets proteoglycans?
'Synovial space' is a region where water is released by _____________ during loading of joints.
'Synovial space' is a region where water is released by _____________ during loading of joints.
'Regression to a more fetal type molecule' in osteoarthritis refers to a reversion to which chondroitin sulfate form?
'Regression to a more fetal type molecule' in osteoarthritis refers to a reversion to which chondroitin sulfate form?
What stimulates cartilage metabolism and synthesis?
What stimulates cartilage metabolism and synthesis?
What inhibits the action of MMP enzymes in normal cartilage?
What inhibits the action of MMP enzymes in normal cartilage?
Which enzymes are considered the 'villains' in the context of hyaline articular cartilage degradation?
Which enzymes are considered the 'villains' in the context of hyaline articular cartilage degradation?
What is the main target of stromelysin, also known as MMP 3?
What is the main target of stromelysin, also known as MMP 3?
What upregulates the neutral matrix metalloproteases (NMMPs) according to the text?
What upregulates the neutral matrix metalloproteases (NMMPs) according to the text?
In osteoarthritis, which enzyme targets the collagen arcade specifically?
In osteoarthritis, which enzyme targets the collagen arcade specifically?
What inhibits and blocks the metalloprotease enzymes in normal hyaline articular cartilage?
What inhibits and blocks the metalloprotease enzymes in normal hyaline articular cartilage?
Which enzyme targets proteoglycans in the context of osteoarthritis?
Which enzyme targets proteoglycans in the context of osteoarthritis?
What is considered a characteristic of normal chondrocytes in hyaline articular cartilage?
What is considered a characteristic of normal chondrocytes in hyaline articular cartilage?
'Nasty' MMPs in osteoarthritis include which specific enzymes?
'Nasty' MMPs in osteoarthritis include which specific enzymes?
What stimulates cartilage metabolism and synthesis according to the text?
What stimulates cartilage metabolism and synthesis according to the text?
Which enzyme is responsible for targeting PGs, or proteoglycans?
Which enzyme is responsible for targeting PGs, or proteoglycans?
What is the primary function of hyaline articular cartilage proteoglycans?
What is the primary function of hyaline articular cartilage proteoglycans?
Where are the glycosaminoglycan (GAG) side chains attached in the proteoglycan monomers?
Where are the glycosaminoglycan (GAG) side chains attached in the proteoglycan monomers?
Why are proteoglycan aggregates described as 'prisoners' in the collagen network?
Why are proteoglycan aggregates described as 'prisoners' in the collagen network?
What is the main component responsible for attracting water into hyaline articular cartilage?
What is the main component responsible for attracting water into hyaline articular cartilage?
In which region of the proteoglycan core protein is keratan sulfate (KS) located?
In which region of the proteoglycan core protein is keratan sulfate (KS) located?
What effect do glycosaminoglycans (GAGs) being negatively charged have on hyaline articular cartilage?
What effect do glycosaminoglycans (GAGs) being negatively charged have on hyaline articular cartilage?
'Regression to a more fetal type molecule' in osteoarthritis refers to a reversion to which form of chondroitin sulfate?
'Regression to a more fetal type molecule' in osteoarthritis refers to a reversion to which form of chondroitin sulfate?
What is the primary role of the hyaluronic acid binding region (HABR) in proteoglycan aggregates?
What is the primary role of the hyaluronic acid binding region (HABR) in proteoglycan aggregates?
