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Questions and Answers
If the pericardial cavity were to accumulate an excessive amount of fluid, potentially restricting the heart's movement, which condition would this induce?
If the pericardial cavity were to accumulate an excessive amount of fluid, potentially restricting the heart's movement, which condition would this induce?
- Pericarditis, leading to inflamed pericardial surfaces.
- Myocardial infarction, causing a loss of blood flow to the heart.
- Cardiac tamponade, restricting heart movement. (correct)
- Endocarditis, resulting in inflammation of the heart's inner lining.
Which blood vessels are responsible for carrying blood away from the heart, regardless of the oxygen content?
Which blood vessels are responsible for carrying blood away from the heart, regardless of the oxygen content?
- Capillaries, facilitating exchange between blood and tissues.
- Arteries, carrying blood away from the heart. (correct)
- Venules, collecting blood from capillaries.
- Veins, returning blood to the heart.
Which heart chamber receives blood from the systemic circuit, which has circulated throughout the body?
Which heart chamber receives blood from the systemic circuit, which has circulated throughout the body?
- Left atrium
- Right ventricle
- Right atrium (correct)
- Left ventricle
Within the pericardium, what is the specific location of the pericardial fluid, crucial for minimizing friction as the heart beats?
Within the pericardium, what is the specific location of the pericardial fluid, crucial for minimizing friction as the heart beats?
What is the functional significance of the capillary vessels within the cardiovascular system?
What is the functional significance of the capillary vessels within the cardiovascular system?
A surgeon performing a heart operation refers to the coronary sulcus. What anatomical landmark is the surgeon most likely referencing?
A surgeon performing a heart operation refers to the coronary sulcus. What anatomical landmark is the surgeon most likely referencing?
Which circuit is responsible for transporting oxygen-depleted blood to the lungs for oxygenation and then returning oxygen-rich blood back to the heart?
Which circuit is responsible for transporting oxygen-depleted blood to the lungs for oxygenation and then returning oxygen-rich blood back to the heart?
In a patient diagnosed with pericarditis, what specific physical sign would a clinician most likely detect during auscultation of the heart?
In a patient diagnosed with pericarditis, what specific physical sign would a clinician most likely detect during auscultation of the heart?
Which layer of the heart wall is also known as the visceral layer of the serous pericardium?
Which layer of the heart wall is also known as the visceral layer of the serous pericardium?
If the cardiac skeleton were compromised, which of the following functions would be MOST directly affected?
If the cardiac skeleton were compromised, which of the following functions would be MOST directly affected?
A congenital defect results in an incomplete closure of the foramen ovale after birth. What is the MOST likely consequence of this condition?
A congenital defect results in an incomplete closure of the foramen ovale after birth. What is the MOST likely consequence of this condition?
Why are the chordae tendineae and papillary muscles critical for the function of the atrioventricular valves?
Why are the chordae tendineae and papillary muscles critical for the function of the atrioventricular valves?
If a patient has damage to the pectinate muscles of the right atrium, what would be the MOST likely physiological consequence?
If a patient has damage to the pectinate muscles of the right atrium, what would be the MOST likely physiological consequence?
Which of the following accurately describes the structural relationship between the interatrial and interventricular septa?
Which of the following accurately describes the structural relationship between the interatrial and interventricular septa?
What functional problem would you expect if the elastic tissue within the connective tissues of the heart were compromised?
What functional problem would you expect if the elastic tissue within the connective tissues of the heart were compromised?
A patient presents with blood backing up into the systemic circulation. Which valve is MOST likely failing?
A patient presents with blood backing up into the systemic circulation. Which valve is MOST likely failing?
During a cardiac catheterization, a dye is injected into the superior vena cava. Which heart chamber will the dye enter FIRST?
During a cardiac catheterization, a dye is injected into the superior vena cava. Which heart chamber will the dye enter FIRST?
How do semilunar valves and atrioventricular (AV) valves differ in structure and function?
How do semilunar valves and atrioventricular (AV) valves differ in structure and function?
What is the primary significance of the prolonged absolute refractory period in cardiac contractile cells?
What is the primary significance of the prolonged absolute refractory period in cardiac contractile cells?
How does the entry of extracellular calcium ions ($Ca^{2+}$) during the plateau phase of a cardiac action potential contribute to cardiac muscle contraction?
How does the entry of extracellular calcium ions ($Ca^{2+}$) during the plateau phase of a cardiac action potential contribute to cardiac muscle contraction?
Which cellular structure is MOST directly responsible for the transfer of the force of contraction between adjacent cardiac muscle cells?
Which cellular structure is MOST directly responsible for the transfer of the force of contraction between adjacent cardiac muscle cells?
How does an increase in heart rate affect the duration of the different phases of the cardiac cycle, and why is this significant?
How does an increase in heart rate affect the duration of the different phases of the cardiac cycle, and why is this significant?
What is the primary energy source for cardiac contractions, and how is it maintained even under increased demand?
What is the primary energy source for cardiac contractions, and how is it maintained even under increased demand?
During which phase of the cardiac cycle does the blood pressure within the ventricles typically reach its minimum value?
During which phase of the cardiac cycle does the blood pressure within the ventricles typically reach its minimum value?
Why are cardiac muscle cells highly sensitive to changes in extracellular calcium ion ($Ca^{2+}$) concentrations, and what mechanisms regulate intracellular $Ca^{2+}$ levels to maintain proper cardiac function?
Why are cardiac muscle cells highly sensitive to changes in extracellular calcium ion ($Ca^{2+}$) concentrations, and what mechanisms regulate intracellular $Ca^{2+}$ levels to maintain proper cardiac function?
Which of the following accurately describes the role of arterial anastomoses in the heart's circulatory system?
Which of the following accurately describes the role of arterial anastomoses in the heart's circulatory system?
A patient experiencing chest pain upon exertion is diagnosed with angina pectoris. Which pathophysiological mechanism is the MOST likely cause of this condition?
A patient experiencing chest pain upon exertion is diagnosed with angina pectoris. Which pathophysiological mechanism is the MOST likely cause of this condition?
Following a myocardial infarction (MI) in the left ventricle, which of the following consequences is MOST likely?
Following a myocardial infarction (MI) in the left ventricle, which of the following consequences is MOST likely?
Which of the following represents the MOST common etiology of a myocardial infarction (MI)?
Which of the following represents the MOST common etiology of a myocardial infarction (MI)?
Atherosclerotic plaques in coronary artery disease (CAD) MOST directly cause myocardial ischemia through which mechanism?
Atherosclerotic plaques in coronary artery disease (CAD) MOST directly cause myocardial ischemia through which mechanism?
Occlusion of the posterior interventricular artery would MOST directly affect the blood supply to which of the following?
Occlusion of the posterior interventricular artery would MOST directly affect the blood supply to which of the following?
What is the MOST direct consequence of coronary ischemia on cardiac function?
What is the MOST direct consequence of coronary ischemia on cardiac function?
Which cardiac vein drains the area supplied by the anterior interventricular artery?
Which cardiac vein drains the area supplied by the anterior interventricular artery?
If the circumflex artery were to become severely blocked, which structure would be MOST at risk?
If the circumflex artery were to become severely blocked, which structure would be MOST at risk?
Which statement BEST explains why elevated blood pressure helps maintain blood flow through the coronary arteries?
Which statement BEST explains why elevated blood pressure helps maintain blood flow through the coronary arteries?
If the AV node were to become the primary pacemaker of the heart, what would be the expected heart rate, and what impact would this have on the ECG?
If the AV node were to become the primary pacemaker of the heart, what would be the expected heart rate, and what impact would this have on the ECG?
How would damage to the bundle branches specifically affect the heart's function and what changes might you observe on an ECG?
How would damage to the bundle branches specifically affect the heart's function and what changes might you observe on an ECG?
What physiological consequence would result from a significant prolongation of the P-R interval, and what does this prolongation indicate about the heart's electrical activity?
What physiological consequence would result from a significant prolongation of the P-R interval, and what does this prolongation indicate about the heart's electrical activity?
What is the functional significance of the moderator band, and how does its presence contribute to the overall efficiency of ventricular contraction?
What is the functional significance of the moderator band, and how does its presence contribute to the overall efficiency of ventricular contraction?
How would impaired function of the intercalated discs affect cardiac muscle physiology, and which specific components of these discs would be most critical in this scenario?
How would impaired function of the intercalated discs affect cardiac muscle physiology, and which specific components of these discs would be most critical in this scenario?
If the resting membrane potential of ventricular cells were to gradually depolarize from -90mV to -60mV, what effect would this have on cardiac muscle function, and how would it manifest clinically?
If the resting membrane potential of ventricular cells were to gradually depolarize from -90mV to -60mV, what effect would this have on cardiac muscle function, and how would it manifest clinically?
What is the underlying mechanism that allows for the spontaneous depolarization of pacemaker cells in the SA node, distinguishing them from other cardiac cells?
What is the underlying mechanism that allows for the spontaneous depolarization of pacemaker cells in the SA node, distinguishing them from other cardiac cells?
How would an ectopic pacemaker in the ventricles affect the normal sequence of cardiac excitation, and what specific ECG changes would likely be observed?
How would an ectopic pacemaker in the ventricles affect the normal sequence of cardiac excitation, and what specific ECG changes would likely be observed?
What is the significance of the delay in impulse conduction at the AV node, and how does this delay contribute to efficient cardiac function?
What is the significance of the delay in impulse conduction at the AV node, and how does this delay contribute to efficient cardiac function?
How does the distribution of Purkinje fibers within the ventricular myocardium optimize ventricular contraction, and what would be the consequence of their dysfunction?
How does the distribution of Purkinje fibers within the ventricular myocardium optimize ventricular contraction, and what would be the consequence of their dysfunction?
Flashcards
Cardiovascular System
Cardiovascular System
Includes the heart, blood, and blood vessels, working together to circulate blood throughout the body.
Pulmonary Circuit
Pulmonary Circuit
The circuit that carries deoxygenated blood from the heart to the lungs for oxygenation and returns oxygenated blood back to the heart.
Systemic Circuit
Systemic Circuit
The circuit that carries oxygenated blood from the heart to the rest of the body and returns deoxygenated blood back to the heart.
Arteries
Arteries
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Veins
Veins
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Atria
Atria
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Ventricles
Ventricles
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Sulci
Sulci
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Epicardium
Epicardium
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Myocardium
Myocardium
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Endocardium
Endocardium
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Cardiac skeleton
Cardiac skeleton
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Interatrial septum
Interatrial septum
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Interventricular septum
Interventricular septum
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Atrioventricular (AV) Valves
Atrioventricular (AV) Valves
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Tricuspid Valve
Tricuspid Valve
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Superior Vena Cava
Superior Vena Cava
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Inferior Vena Cava
Inferior Vena Cava
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AV Node
AV Node
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Purkinje Fibers
Purkinje Fibers
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Pacemaker Potential
Pacemaker Potential
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Arrhythmias
Arrhythmias
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Bradycardia
Bradycardia
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Tachycardia
Tachycardia
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Ectopic Pacemaker
Ectopic Pacemaker
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Coronary Arteries
Coronary Arteries
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Electrocardiogram (ECG/EKG)
Electrocardiogram (ECG/EKG)
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P Wave (ECG)
P Wave (ECG)
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Right Coronary Artery (RCA)
Right Coronary Artery (RCA)
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Intercalated Discs
Intercalated Discs
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Left Coronary Artery (LCA)
Left Coronary Artery (LCA)
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Arterial Anastomoses
Arterial Anastomoses
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Great Cardiac Vein
Great Cardiac Vein
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Coronary Artery Disease (CAD)
Coronary Artery Disease (CAD)
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Coronary Ischemia
Coronary Ischemia
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Angina Pectoris
Angina Pectoris
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Myocardial Infarction (MI)
Myocardial Infarction (MI)
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Coronary Thrombosis
Coronary Thrombosis
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Rapid Depolarization
Rapid Depolarization
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Plateau (Cardiac Action Potential)
Plateau (Cardiac Action Potential)
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Repolarization
Repolarization
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Absolute Refractory Period
Absolute Refractory Period
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Relative Refractory Period
Relative Refractory Period
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Systole
Systole
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Study Notes
- The cardiovascular system includes the heart, blood, and blood vessels
- The heart beats around 100,000 times each day
- The heart pumps approximately 8,000 liters of blood each day
Heart Circuits
- Pulmonary circuit: carries blood to and from the gas exchange surfaces of the lungs
- Systemic circuit: carries blood to and from the rest of the body
- Both circuits begin and end at the heart, and blood travels through them sequentially
Blood Vessels
- Arteries: carry blood away from the heart
- Veins: return blood to the heart
- Capillaries: exchange vessels, interconnect smallest arteries and smallest veins and exchange dissolved gases, nutrients, and wastes between blood and surrounding tissues
Heart Chambers
- Right atrium: receives blood from the systemic circuit
- Right ventricle: pumps blood into the pulmonary circuit
- Left atrium: receives blood from the pulmonary circuit
- Left ventricle: pumps blood into the systemic circuit
Heart Position
- Great vessels connect to the heart at its base (superior)
- The pointed tip of the heart is the apex (inferior)
- The heart sits between two pleural cavities in the mediastinum and is surrounded by the pericardium
Pericardium Layers
- Outer fibrous pericardium
- Inner serous pericardium:
- Outer parietal layer
- Inner visceral layer
- Pericardial cavity: between parietal and visceral layers and contains pericardial fluid
- Pericarditis is caused by pathogens in the pericardium: inflamed pericardial surfaces rub against each other, producing a distinctive scratching sound
Additional Heart Info
- Cardiac tamponade: restricted movement of the heart because of excess fluid in the pericardial cavity
- Atria: two thin-walled upper right and left chambers of the heart, each with an expandable outer auricle
- Sulci: grooves that contain fat and blood vessels
- Coronary sulcus: marks the border between atria and ventricles
Ventricles
- Anterior and posterior interventricular sulcus: mark the boundary between left and right ventricles
- Epicardium: covers outer surface of the heart; also known as the visceral layer of serous pericardium
- Parietal layer of the serous pericardium covers the visceral layer
- Myocardium: cardiac muscle tissue
- Endocardium: covers inner surface of the heart
Connective Tissue
- Physically supports cardiac muscle fibers, blood vessels, and nerves of the myocardium
- Distributes forces of contraction
- Adds strength and prevents overexpansion
- Provides elasticity to help return the heart to its original size after contraction
- The cardiac skeleton has four dense bands of tough elastic tissue
Heart Info
- Cardiac Skeleton: encircles heart valves and bases of pulmonary trunk and aorta and stabilizes position of heart valves and ventricular muscle cells; electrically insulates ventricular cells from atrial cells
- Septa: muscular partitions that separate the chambers of the heart
- Interatrial septum: separates atria
- Interventricular septum: separates ventricles and is much thicker than the interatrial septum
Valves
- Atrioventricular valves: separate the atria from the ventricles, including the tricuspid and mitral valves
- Atrioventricular Valves consist of folds of fibrous tissue, extend into openings between the atria and ventricles, and permit blood flow only in one direction
- From the right atrium to the right ventricle
- From the left atrium to the left ventricle
- Semilunar valves: aortic and pulmonary valves that prevent backflow of blood into the ventricles
Heart Information
- Right atrium receives blood from the superior and the inferior vena cava
- Superior vena cava: carries blood from the head, neck, upper limbs, and chest
- Inferior vena cava: carries blood from the trunk, viscera, and lower limbs
- Foramen ovale: opening through the interatrial septum that connects the two atria of the fetal heart; it closes at birth, eventually forming the fossa ovalis
- Pectinate muscles: prominent muscular ridges on the anterior atrial wall and inner surface of the auricle
Triscuspid Valve
- Blood flows from right atrium to right ventricle through the tricuspid valve, which has three cusps
- Free valve edges attach to chordae tendineae from papillary muscles of the ventricle and prevent the valve from opening backward
Ventricles
- Trabeculae carneae: muscular ridges on the internal surface of both right and left ventricles
- Moderator band: muscular ridge that delivers stimulus for contraction to the papillary muscles
- Conus arteriosus: at the superior end of the right ventricle and ends at the pulmonary valve
Heart Info
- Pulmonary Valve has three semilunar cusps
- The Pulmonary valve leads to pulmonary trunk which:
- Begins the pulmonary circuit
- Divides into left and right pulmonary arteries
- Left atrium receives blood from left and right pulmonary veins
- Blood flows from the left atrium to the left ventricle through the mitral valve
Mitral Valve
- There are two cusps on the mitral valve
- Blood leaves the left ventricle through the aortic valve into the ascending aorta
- Aortic sinuses are saclike expansions at base of ascending aorta
- Ascending aorta turns to become aortic arch
Heart Characteristics
- Right ventricle holds the same amount of blood as the left ventricle, but has thinner walls, develops less pressure and is more pouch-shaped than round
- Heart valves prevent backflow of blood
- Atrioventricular valves are between atria and ventricles, consisting of the tricuspid and mitral valves
Contraction
- When ventricles contract, blood pressure closes AV valves
- Papillary muscles contract and tense chordae tendineae to prevent regurgitation of blood into the atria
- Regurgitation is the backflow of blood
- Semilunar valves prevent backflow of blood into ventricles
Cardiac Info
- There are two semilunar valves: pulmonary and aortic valves with no muscular braces
- Valvular heart disease: deterioration of valve function which may develop after carditis, or inflammation of the heart, or result from rheumatic fever
- Coronary circulation supplies blood first to the muscle tissue of the heart
Coronary Arteries
- Originate at the aortic sinuses Elevated blood pressure and elastic rebound of the aorta maintain blood flow through the coronary arteries
- Right coronary artery supplies blood to the right atrium, portions of both ventricles, and portions of the electrical conducting system of the hear
Cardiac Arteries
- Right Coronary artery rises into what:
- Marginal arteries
- Posterior interventricular artery
- Left coronary artery supplies blood to the left atrium, left ventricle, and interventricular septum with branches into the circumflex artery and anterior interventricular artery
- Arterial anastomoses: interconnect anterior and posterior interventricular arteries, maintaining a constant blood supply to cardiac muscle
Cardiac Veins
- Great cardiac vein: drains blood from the region supplied by the anterior interventricular artery; returns blood to the coronary sinus and opens into right atrium Posterior vein of left ventricle, middle cardiac vein, and small cardiac vein empty into great cardiac vein or coronary sinus
- Anterior cardiac veins empty into right atrium
Ischemia
- Coronary artery disease is an area of partial or complete blockage of coronary circulation
- Cardiac muscle cells need a constant supply of oxygen and nutrients, and reduced blood flow impairs heart muscle performance
- Coronary ischemia: reduces circulatory supply from partial or complete blockage of coronary arteries
- The usual cause of CAD is formation of a fatty deposit or atherosclerotic plaque in the wall of a coronary vessel
Cardiac Disease
- Plaque/thrombus in coronary arteries narrow the passageway and reduces blood flow
- Spasms in smooth muscles of vessel walls can further decrease/stop blood flow
- Angina pectoris: chest pain, commonly symptom of CAD, develops when workload of heart increases; individual feel comfortable at rest
Myocardial Infarction
- MI: part of coronary circulation becomes blocked known as a heart attack.
-
- Cardiac muscle cells deprived of oxygen die
-
- Resulting tissue death creates a nomfunctional area called an infarct
Heart Arrhythmias
- Arrhythmias: disturbances in heart rate
- Bradycardia: slow heart rate
- Tachycardia: fast heart rate
- Ectopic Pacemaker: abnormal cells generate high rate of action potential. Bypasses conducting system Disrupts timing of ventricular contractions. Electrocardiogram: recording of electrical events in the heart, abnormal patterns are used to diagnose damage
ECG
- P wave: atrial depolarization
- QRS complex: ventricular depolarization. Ventricles begin contracting shortly after R wave.
- T wave: ventricle repolarization, Intervals:
- P-R: from start of atrial depolarization to start of QRS complex
- Q-T: time required for ventricles to undergo a single cycle of: Depolarization Repolarization
Cardiac Contractions
- Receives stimulus from Purkinje fibers
- Resting membrane potential.
- Of ventricular cell is about –90 mV Of atrial cell is about -80 mV
Heart Tissue
- Small Size
- Single central nucleus. Intercalated discs, branch interconnections between cells Rapid depolarization. Massive influx of Na+ through fast sodium channels. Extracellular Ca2+ enters cytosol through slow calcium channels Repolarization.
- K+ rushes out of cell through slow potassium channels
Role of Calcium Ions in Cardiac Contraction
- Extracellular Ca2+ crosses plasma membrane during plateau phase, provides roughly 20% of Ca2+ required for contraction.
- Entry of extracellular Ca2+ triggers release of additional Ca2+ from sarcoplasmic reticulum
- Aerobic Energy with circulation being delivered, cardiac contractile cells store myoglobin
Cardiac Cycle
- From start of one heartbeat to beginning of next heartbeat. Alternating periods of contraction and relaxation
- Includes alternating periods of contraction and relaxation
- Systole: contraction
- Diastole: relaxation
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Description
Explore key aspects of the cardiovascular system: fluid accumulation in the pericardial cavity, blood vessels carrying blood away from the heart, and the heart chamber receiving blood from the systemic circuit. This also covers the location of pericardial fluid, the functional significance of capillary vessels, the anatomical landmark of the coronary sulcus, and the circuit responsible for transporting blood to the lungs.