Cardiovascular System Review
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Questions and Answers

If the pericardial cavity were to accumulate an excessive amount of fluid, potentially restricting the heart's movement, which condition would this induce?

  • Pericarditis, leading to inflamed pericardial surfaces.
  • Myocardial infarction, causing a loss of blood flow to the heart.
  • Cardiac tamponade, restricting heart movement. (correct)
  • Endocarditis, resulting in inflammation of the heart's inner lining.

Which blood vessels are responsible for carrying blood away from the heart, regardless of the oxygen content?

  • Capillaries, facilitating exchange between blood and tissues.
  • Arteries, carrying blood away from the heart. (correct)
  • Venules, collecting blood from capillaries.
  • Veins, returning blood to the heart.

Which heart chamber receives blood from the systemic circuit, which has circulated throughout the body?

  • Left atrium
  • Right ventricle
  • Right atrium (correct)
  • Left ventricle

Within the pericardium, what is the specific location of the pericardial fluid, crucial for minimizing friction as the heart beats?

<p>The region separating the parietal and visceral layers. (C)</p> Signup and view all the answers

What is the functional significance of the capillary vessels within the cardiovascular system?

<p>Exchanging dissolved gases, nutrients, and wastes between the blood and surrounding tissues. (B)</p> Signup and view all the answers

A surgeon performing a heart operation refers to the coronary sulcus. What anatomical landmark is the surgeon most likely referencing?

<p>The division between the atria and ventricles. (A)</p> Signup and view all the answers

Which circuit is responsible for transporting oxygen-depleted blood to the lungs for oxygenation and then returning oxygen-rich blood back to the heart?

<p>Pulmonary circuit (C)</p> Signup and view all the answers

In a patient diagnosed with pericarditis, what specific physical sign would a clinician most likely detect during auscultation of the heart?

<p>A distinctive scratching sound caused by inflamed pericardial surfaces rubbing together. (C)</p> Signup and view all the answers

Which layer of the heart wall is also known as the visceral layer of the serous pericardium?

<p>Epicardium (B)</p> Signup and view all the answers

If the cardiac skeleton were compromised, which of the following functions would be MOST directly affected?

<p>Electrical insulation between the atria and ventricles (C)</p> Signup and view all the answers

A congenital defect results in an incomplete closure of the foramen ovale after birth. What is the MOST likely consequence of this condition?

<p>Mixing of oxygenated and deoxygenated blood (A)</p> Signup and view all the answers

Why are the chordae tendineae and papillary muscles critical for the function of the atrioventricular valves?

<p>They prevent the valve cusps from inverting back into the atria during ventricular contraction. (B)</p> Signup and view all the answers

If a patient has damage to the pectinate muscles of the right atrium, what would be the MOST likely physiological consequence?

<p>Decreased efficiency of atrial contraction (B)</p> Signup and view all the answers

Which of the following accurately describes the structural relationship between the interatrial and interventricular septa?

<p>The interventricular septum is much thicker than the interatrial septum because it must withstand higher pressures. (C)</p> Signup and view all the answers

What functional problem would you expect if the elastic tissue within the connective tissues of the heart were compromised?

<p>Impaired ability of the heart to return to its original shape after contraction (A)</p> Signup and view all the answers

A patient presents with blood backing up into the systemic circulation. Which valve is MOST likely failing?

<p>Aortic Valve (A)</p> Signup and view all the answers

During a cardiac catheterization, a dye is injected into the superior vena cava. Which heart chamber will the dye enter FIRST?

<p>Right Atrium (B)</p> Signup and view all the answers

How do semilunar valves and atrioventricular (AV) valves differ in structure and function?

<p>Semilunar valves prevent backflow of blood into the ventricles, while AV valves prevent backflow into the atria. (A)</p> Signup and view all the answers

What is the primary significance of the prolonged absolute refractory period in cardiac contractile cells?

<p>It prevents tetany, ensuring that the heart muscle relaxes between contractions. (D)</p> Signup and view all the answers

How does the entry of extracellular calcium ions ($Ca^{2+}$) during the plateau phase of a cardiac action potential contribute to cardiac muscle contraction?

<p>It triggers the release of additional $Ca^{2+}$ from the sarcoplasmic reticulum, amplifying the contraction signal. (D)</p> Signup and view all the answers

Which cellular structure is MOST directly responsible for the transfer of the force of contraction between adjacent cardiac muscle cells?

<p>Intercalated discs (A)</p> Signup and view all the answers

How does an increase in heart rate affect the duration of the different phases of the cardiac cycle, and why is this significant?

<p>It selectively shortens diastole, potentially reducing ventricular filling time. (B)</p> Signup and view all the answers

What is the primary energy source for cardiac contractions, and how is it maintained even under increased demand?

<p>Aerobic metabolism of fatty acids and glucose, supported by myoglobin and coronary circulation. (D)</p> Signup and view all the answers

During which phase of the cardiac cycle does the blood pressure within the ventricles typically reach its minimum value?

<p>Ventricular diastole (B)</p> Signup and view all the answers

Why are cardiac muscle cells highly sensitive to changes in extracellular calcium ion ($Ca^{2+}$) concentrations, and what mechanisms regulate intracellular $Ca^{2+}$ levels to maintain proper cardiac function?

<p>Because extracellular $Ca^{2+}$ entry is a key component of the plateau phase and influences the amount of $Ca^{2+}$ released from the SR. (C)</p> Signup and view all the answers

Which of the following accurately describes the role of arterial anastomoses in the heart's circulatory system?

<p>They ensure a continuous blood supply to the cardiac muscle by interconnecting the anterior and posterior interventricular arteries. (D)</p> Signup and view all the answers

A patient experiencing chest pain upon exertion is diagnosed with angina pectoris. Which pathophysiological mechanism is the MOST likely cause of this condition?

<p>Temporary myocardial ischemia due to increased cardiac workload and reduced blood flow. (D)</p> Signup and view all the answers

Following a myocardial infarction (MI) in the left ventricle, which of the following consequences is MOST likely?

<p>Formation of an infarct, resulting in a nonfunctional area and potential reduction in overall cardiac function. (D)</p> Signup and view all the answers

Which of the following represents the MOST common etiology of a myocardial infarction (MI)?

<p>Coronary thrombosis at the site of an atherosclerotic plaque, leading to obstruction of blood flow. (A)</p> Signup and view all the answers

Atherosclerotic plaques in coronary artery disease (CAD) MOST directly cause myocardial ischemia through which mechanism?

<p>Narrowing the passageway of coronary vessels, reducing blood flow and oxygen supply to the heart muscle. (C)</p> Signup and view all the answers

Occlusion of the posterior interventricular artery would MOST directly affect the blood supply to which of the following?

<p>The right atrium and portions of both ventricles. (A)</p> Signup and view all the answers

What is the MOST direct consequence of coronary ischemia on cardiac function?

<p>Reduced cardiac performance due to decreased oxygen and nutrient supply. (C)</p> Signup and view all the answers

Which cardiac vein drains the area supplied by the anterior interventricular artery?

<p>Great cardiac vein (D)</p> Signup and view all the answers

If the circumflex artery were to become severely blocked, which structure would be MOST at risk?

<p>Left ventricle (A)</p> Signup and view all the answers

Which statement BEST explains why elevated blood pressure helps maintain blood flow through the coronary arteries?

<p>Elevated blood pressure and the elastic rebound of the aorta maintain blood flow through the coronary arteries. (B)</p> Signup and view all the answers

If the AV node were to become the primary pacemaker of the heart, what would be the expected heart rate, and what impact would this have on the ECG?

<p>40-60 bpm; the ECG might show an absent or inverted P wave. (D)</p> Signup and view all the answers

How would damage to the bundle branches specifically affect the heart's function and what changes might you observe on an ECG?

<p>Disrupt the coordinated depolarization of the ventricles, possibly leading to a widened QRS complex on the ECG. (A)</p> Signup and view all the answers

What physiological consequence would result from a significant prolongation of the P-R interval, and what does this prolongation indicate about the heart's electrical activity?

<p>Delayed transmission of the action potential from the atria to the ventricles, potentially indicating a first-degree AV block. (A)</p> Signup and view all the answers

What is the functional significance of the moderator band, and how does its presence contribute to the overall efficiency of ventricular contraction?

<p>Carries the Purkinje fibers to the papillary muscles, allowing for the prompt contraction of these muscles and proper tension of the chordae tendineae before ventricular contraction. (C)</p> Signup and view all the answers

How would impaired function of the intercalated discs affect cardiac muscle physiology, and which specific components of these discs would be most critical in this scenario?

<p>Disrupted electrical synchronicity and weakened force of contraction, mainly due to malfunction of the gap junctions. (C)</p> Signup and view all the answers

If the resting membrane potential of ventricular cells were to gradually depolarize from -90mV to -60mV, what effect would this have on cardiac muscle function, and how would it manifest clinically?

<p>Decreased excitability and potential for arrhythmias, clinically indicated by an irregular heart rhythm. (C)</p> Signup and view all the answers

What is the underlying mechanism that allows for the spontaneous depolarization of pacemaker cells in the SA node, distinguishing them from other cardiac cells?

<p>Unique ion channels that open at negative membrane potentials, allowing a slow influx of sodium ions and a decreased efflux of potassium ions. (C)</p> Signup and view all the answers

How would an ectopic pacemaker in the ventricles affect the normal sequence of cardiac excitation, and what specific ECG changes would likely be observed?

<p>It would cause premature ventricular contractions and result in a widened QRS complex without a preceding P wave on the ECG. (D)</p> Signup and view all the answers

What is the significance of the delay in impulse conduction at the AV node, and how does this delay contribute to efficient cardiac function?

<p>It allows the atria to contract and empty blood into the ventricles before ventricular systole, ensuring optimal ventricular filling. (C)</p> Signup and view all the answers

How does the distribution of Purkinje fibers within the ventricular myocardium optimize ventricular contraction, and what would be the consequence of their dysfunction?

<p>They conduct impulses rapidly and uniformly, ensuring a synchronized and powerful contraction across the ventricles. (A)</p> Signup and view all the answers

Flashcards

Cardiovascular System

Includes the heart, blood, and blood vessels, working together to circulate blood throughout the body.

Pulmonary Circuit

The circuit that carries deoxygenated blood from the heart to the lungs for oxygenation and returns oxygenated blood back to the heart.

Systemic Circuit

The circuit that carries oxygenated blood from the heart to the rest of the body and returns deoxygenated blood back to the heart.

Arteries

Vessels that carry blood away from the heart.

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Veins

Vessels that return blood to the heart.

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Atria

The receiving chambers of the heart that receive blood from either the systemic or pulmonary circuits.

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Ventricles

The pumping chambers of the heart that pump blood into the pulmonary and systemic circuits.

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Sulci

Grooves on the surface of the heart that contain fat and blood vessels.

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Epicardium

Outer layer of the heart, also known as the visceral layer of the serous pericardium.

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Myocardium

Cardiac muscle tissue layer of the heart wall.

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Endocardium

Inner surface covering of the heart.

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Cardiac skeleton

Dense bands of elastic tissue that encircle heart valves and stabilize them.

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Interatrial septum

Muscular partition separating the atria.

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Interventricular septum

Muscular partition separating the ventricles; thicker than the interatrial septum.

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Atrioventricular (AV) Valves

Valves located between the atria and ventricles, including the tricuspid and mitral valves.

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Tricuspid Valve

Valve that prevents backflow of blood from the right ventricle into the right atrium.

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Superior Vena Cava

Carries blood from the head, neck, upper limbs, and chest to the right atrium.

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Inferior Vena Cava

Receives blood from the trunk, viscera, and lower limbs, and empties blood into the right atrium.

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AV Node

Specialized conducting cells at the junction between the atria and ventricles.

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Purkinje Fibers

Fibers in the ventricles that distribute the impulse to the ventricular myocardium.

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Pacemaker Potential

Gradual depolarization of pacemaker cells; they do NOT have a stable resting membrane potential.

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Arrhythmias

Disturbances in heart rhythm.

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Bradycardia

Abnormally slow heart rate.

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Tachycardia

Abnormally fast heart rate.

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Ectopic Pacemaker

Abnormal cells generate a high rate of action potentials, bypassing the normal conducting system and disrupting ventricular contractions.

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Coronary Arteries

Arteries originating at aortic sinuses that supply blood to the heart muscle.

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Electrocardiogram (ECG/EKG)

A recording of electrical events in the heart obtained via electrodes on the body surface.

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P Wave (ECG)

Depolarization of the atria.

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Right Coronary Artery (RCA)

Supplies blood to the right atrium, portions of both ventricles, and parts of the heart's electrical system.

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Intercalated Discs

Specialized connections between cardiac contractile cells, containing desmosomes and gap junctions.

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Left Coronary Artery (LCA)

Supplies blood to the left atrium, left ventricle and interventricular septum.

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Arterial Anastomoses

Interconnections between arteries that maintain constant blood supply to the heart muscle.

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Great Cardiac Vein

Drains blood from the anterior interventricular artery region and returns it to the right atrium via the coronary sinus.

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Coronary Artery Disease (CAD)

Areas of partial or complete blockage of coronary circulation, reducing blood flow to the heart muscle.

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Coronary Ischemia

Reduced circulatory supply due to blockage of coronary arteries.

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Angina Pectoris

Chest pain resulting from temporary ischemia during increased workload of the heart.

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Myocardial Infarction (MI)

Blockage of coronary circulation leading to death of cardiac muscle cells.

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Coronary Thrombosis

Thrombus (blood clot) formation at a plaque in a coronary artery, often causing an MI.

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Rapid Depolarization

Rapid influx of Na+ ions, causing a quick change in membrane potential.

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Plateau (Cardiac Action Potential)

Extracellular Ca2+ enters the cytosol extending the duration of depolarization.

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Repolarization

K+ rushes out of the cell, restoring the resting membrane potential.

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Absolute Refractory Period

Time period in a cardiac cell where it cannot respond to any new stimulus.

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Relative Refractory Period

Time when a cardiac cell can respond, but only to a very strong stimulus.

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Systole

The phase of the cardiac cycle when heart muscle contracts.

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Study Notes

  • The cardiovascular system includes the heart, blood, and blood vessels
  • The heart beats around 100,000 times each day
  • The heart pumps approximately 8,000 liters of blood each day

Heart Circuits

  • Pulmonary circuit: carries blood to and from the gas exchange surfaces of the lungs
  • Systemic circuit: carries blood to and from the rest of the body
  • Both circuits begin and end at the heart, and blood travels through them sequentially

Blood Vessels

  • Arteries: carry blood away from the heart
  • Veins: return blood to the heart
  • Capillaries: exchange vessels, interconnect smallest arteries and smallest veins and exchange dissolved gases, nutrients, and wastes between blood and surrounding tissues

Heart Chambers

  • Right atrium: receives blood from the systemic circuit
  • Right ventricle: pumps blood into the pulmonary circuit
  • Left atrium: receives blood from the pulmonary circuit
  • Left ventricle: pumps blood into the systemic circuit

Heart Position

  • Great vessels connect to the heart at its base (superior)
  • The pointed tip of the heart is the apex (inferior)
  • The heart sits between two pleural cavities in the mediastinum and is surrounded by the pericardium

Pericardium Layers

  • Outer fibrous pericardium
  • Inner serous pericardium:
    • Outer parietal layer
  • Inner visceral layer
  • Pericardial cavity: between parietal and visceral layers and contains pericardial fluid
  • Pericarditis is caused by pathogens in the pericardium: inflamed pericardial surfaces rub against each other, producing a distinctive scratching sound

Additional Heart Info

  • Cardiac tamponade: restricted movement of the heart because of excess fluid in the pericardial cavity
  • Atria: two thin-walled upper right and left chambers of the heart, each with an expandable outer auricle
  • Sulci: grooves that contain fat and blood vessels
  • Coronary sulcus: marks the border between atria and ventricles

Ventricles

  • Anterior and posterior interventricular sulcus: mark the boundary between left and right ventricles
  • Epicardium: covers outer surface of the heart; also known as the visceral layer of serous pericardium
  • Parietal layer of the serous pericardium covers the visceral layer
  • Myocardium: cardiac muscle tissue
  • Endocardium: covers inner surface of the heart

Connective Tissue

  • Physically supports cardiac muscle fibers, blood vessels, and nerves of the myocardium
  • Distributes forces of contraction
  • Adds strength and prevents overexpansion
  • Provides elasticity to help return the heart to its original size after contraction
  • The cardiac skeleton has four dense bands of tough elastic tissue

Heart Info

  • Cardiac Skeleton: encircles heart valves and bases of pulmonary trunk and aorta and stabilizes position of heart valves and ventricular muscle cells; electrically insulates ventricular cells from atrial cells
  • Septa: muscular partitions that separate the chambers of the heart
  • Interatrial septum: separates atria
  • Interventricular septum: separates ventricles and is much thicker than the interatrial septum

Valves

  • Atrioventricular valves: separate the atria from the ventricles, including the tricuspid and mitral valves
  • Atrioventricular Valves consist of folds of fibrous tissue, extend into openings between the atria and ventricles, and permit blood flow only in one direction
  • From the right atrium to the right ventricle
  • From the left atrium to the left ventricle
  • Semilunar valves: aortic and pulmonary valves that prevent backflow of blood into the ventricles

Heart Information

  • Right atrium receives blood from the superior and the inferior vena cava
    • Superior vena cava: carries blood from the head, neck, upper limbs, and chest
    • Inferior vena cava: carries blood from the trunk, viscera, and lower limbs
  • Foramen ovale: opening through the interatrial septum that connects the two atria of the fetal heart; it closes at birth, eventually forming the fossa ovalis
  • Pectinate muscles: prominent muscular ridges on the anterior atrial wall and inner surface of the auricle

Triscuspid Valve

  • Blood flows from right atrium to right ventricle through the tricuspid valve, which has three cusps
  • Free valve edges attach to chordae tendineae from papillary muscles of the ventricle and prevent the valve from opening backward

Ventricles

  • Trabeculae carneae: muscular ridges on the internal surface of both right and left ventricles
  • Moderator band: muscular ridge that delivers stimulus for contraction to the papillary muscles
  • Conus arteriosus: at the superior end of the right ventricle and ends at the pulmonary valve

Heart Info

  • Pulmonary Valve has three semilunar cusps
  • The Pulmonary valve leads to pulmonary trunk which:
    • Begins the pulmonary circuit
  • Divides into left and right pulmonary arteries
  • Left atrium receives blood from left and right pulmonary veins
  • Blood flows from the left atrium to the left ventricle through the mitral valve

Mitral Valve

  • There are two cusps on the mitral valve
  • Blood leaves the left ventricle through the aortic valve into the ascending aorta
  • Aortic sinuses are saclike expansions at base of ascending aorta
  • Ascending aorta turns to become aortic arch

Heart Characteristics

  • Right ventricle holds the same amount of blood as the left ventricle, but has thinner walls, develops less pressure and is more pouch-shaped than round
  • Heart valves prevent backflow of blood
  • Atrioventricular valves are between atria and ventricles, consisting of the tricuspid and mitral valves

Contraction

  • When ventricles contract, blood pressure closes AV valves
  • Papillary muscles contract and tense chordae tendineae to prevent regurgitation of blood into the atria
  • Regurgitation is the backflow of blood
  • Semilunar valves prevent backflow of blood into ventricles

Cardiac Info

  • There are two semilunar valves: pulmonary and aortic valves with no muscular braces
  • Valvular heart disease: deterioration of valve function which may develop after carditis, or inflammation of the heart, or result from rheumatic fever
  • Coronary circulation supplies blood first to the muscle tissue of the heart

Coronary Arteries

  • Originate at the aortic sinuses Elevated blood pressure and elastic rebound of the aorta maintain blood flow through the coronary arteries
  • Right coronary artery supplies blood to the right atrium, portions of both ventricles, and portions of the electrical conducting system of the hear

Cardiac Arteries

  • Right Coronary artery rises into what:
    • Marginal arteries
  • Posterior interventricular artery
  • Left coronary artery supplies blood to the left atrium, left ventricle, and interventricular septum with branches into the circumflex artery and anterior interventricular artery
  • Arterial anastomoses: interconnect anterior and posterior interventricular arteries, maintaining a constant blood supply to cardiac muscle

Cardiac Veins

  • Great cardiac vein: drains blood from the region supplied by the anterior interventricular artery; returns blood to the coronary sinus and opens into right atrium Posterior vein of left ventricle, middle cardiac vein, and small cardiac vein empty into great cardiac vein or coronary sinus
  • Anterior cardiac veins empty into right atrium

Ischemia

  • Coronary artery disease is an area of partial or complete blockage of coronary circulation
  • Cardiac muscle cells need a constant supply of oxygen and nutrients, and reduced blood flow impairs heart muscle performance
  • Coronary ischemia: reduces circulatory supply from partial or complete blockage of coronary arteries
  • The usual cause of CAD is formation of a fatty deposit or atherosclerotic plaque in the wall of a coronary vessel

Cardiac Disease

  • Plaque/thrombus in coronary arteries narrow the passageway and reduces blood flow
  • Spasms in smooth muscles of vessel walls can further decrease/stop blood flow
  • Angina pectoris: chest pain, commonly symptom of CAD, develops when workload of heart increases; individual feel comfortable at rest

Myocardial Infarction

  • MI: part of coronary circulation becomes blocked known as a heart attack.
    • Cardiac muscle cells deprived of oxygen die
    • Resulting tissue death creates a nomfunctional area called an infarct

Heart Arrhythmias

  • Arrhythmias: disturbances in heart rate
  • Bradycardia: slow heart rate
  • Tachycardia: fast heart rate
  • Ectopic Pacemaker: abnormal cells generate high rate of action potential. Bypasses conducting system Disrupts timing of ventricular contractions. Electrocardiogram: recording of electrical events in the heart, abnormal patterns are used to diagnose damage

ECG

  • P wave: atrial depolarization
  • QRS complex: ventricular depolarization. Ventricles begin contracting shortly after R wave.
  • T wave: ventricle repolarization, Intervals:
  • P-R: from start of atrial depolarization to start of QRS complex
  • Q-T: time required for ventricles to undergo a single cycle of: Depolarization Repolarization

Cardiac Contractions

  • Receives stimulus from Purkinje fibers
  • Resting membrane potential.
    • Of ventricular cell is about –90 mV Of atrial cell is about -80 mV

Heart Tissue

  • Small Size
  • Single central nucleus. Intercalated discs, branch interconnections between cells Rapid depolarization. Massive influx of Na+ through fast sodium channels. Extracellular Ca2+ enters cytosol through slow calcium channels Repolarization.
  • K+ rushes out of cell through slow potassium channels

Role of Calcium Ions in Cardiac Contraction

  • Extracellular Ca2+ crosses plasma membrane during plateau phase, provides roughly 20% of Ca2+ required for contraction.
  • Entry of extracellular Ca2+ triggers release of additional Ca2+ from sarcoplasmic reticulum
  • Aerobic Energy with circulation being delivered, cardiac contractile cells store myoglobin

Cardiac Cycle

  • From start of one heartbeat to beginning of next heartbeat. Alternating periods of contraction and relaxation
  • Includes alternating periods of contraction and relaxation
  • Systole: contraction
  • Diastole: relaxation

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Description

Explore key aspects of the cardiovascular system: fluid accumulation in the pericardial cavity, blood vessels carrying blood away from the heart, and the heart chamber receiving blood from the systemic circuit. This also covers the location of pericardial fluid, the functional significance of capillary vessels, the anatomical landmark of the coronary sulcus, and the circuit responsible for transporting blood to the lungs.

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