Cardiovascular System: RAAS Medications - ACE Inhibitors & ARBs
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Questions and Answers

Which medication class is known for preventing calcium from entering cells, resulting in decreased heart rate and myocardial contraction?

  • Beta blockers
  • Cardiac Glycosides
  • Vasodilators
  • Calcium Channel Blockers (correct)

Which medication class is primarily used for the treatment of hypertension and angina pectoris?

  • Beta blockers
  • Vasodilators (correct)
  • Organic nitrates
  • Cardiac Glycosides

Which medication is associated with adverse effects such as headaches, drowsiness, flushing, fatigue, dizziness, and edema?

  • Nitroprusside
  • Amlodipine (correct)
  • Digoxin
  • Hydralazine

Which medication is particularly used in severe hypertension but has potential serious side effects?

<p>Minoxidil (C)</p> Signup and view all the answers

Which medication class is known for increasing the force of contraction, slowing conduction, and increasing the refractory period of the heart?

<p>Cardiac Glycosides (C)</p> Signup and view all the answers

What is the mechanism of action of Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors)?

<p>Blocking access to receptors in blood vessels (B)</p> Signup and view all the answers

What is a common side effect of Angiotensin Receptor Blockers (ARBs) according to the text?

<p>Dry irritating nonproductive cough (A)</p> Signup and view all the answers

How do Angiotensin Receptor Blockers (ARBs) differ from Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors)?

<p>They have similar effects but do not inhibit Kinase II (C)</p> Signup and view all the answers

Which condition are Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors) NOT proven to decrease the risk of according to the text?

<p>Asthma (A)</p> Signup and view all the answers

What is a key consideration when administering the first dose of Angiotensin Converting Enzyme Inhibitors (ACE Inhibitors) especially if the patient is on a diuretic?

<p>Lowering the initial dose or stopping the diuretic 2-3 days prior (A)</p> Signup and view all the answers

What is a unique adverse effect associated with quinidine?

<p>Lupus-like syndrome (D)</p> Signup and view all the answers

What is the specific first-line use of quinidine in the African American population?

<p>Hypertensive crisis intervention (A)</p> Signup and view all the answers

What is a common early sign of toxicity associated with quinidine that should be monitored?

<p>Anorexia (C)</p> Signup and view all the answers

Which drug works directly on smooth muscle to promote vein dilation and decrease oxygen demand?

<p>Nitroglycerin (B)</p> Signup and view all the answers

Why is it important to handle nitroglycerin carefully, avoiding light, heat, or moisture?

<p>To maintain its explosive properties (C)</p> Signup and view all the answers

What is the specific use of captopril?

<p>Treatment of heart failure and nephropathy (D)</p> Signup and view all the answers

Which drug category can cause rebound hypertension if stopped abruptly?

<p>ACE inhibitors (B)</p> Signup and view all the answers

What effect does aliskirin have on the Renin-Angiotensin-Aldosterone System (RAAS)?

<p>Suppresses the entire RAAS cascade (B)</p> Signup and view all the answers

Which drug is a selective aldosterone receptor blocker with fewer side effects than spironolactone?

<p>Eplerenone (D)</p> Signup and view all the answers

For which condition is lisinopril specifically used?

<p>Hypertension and heart failure (A)</p> Signup and view all the answers

What is the term for a solution with the same concentration as plasma?

<p>Isotonic (A)</p> Signup and view all the answers

Which part of the nephron is responsible for early reabsorption of sodium and chloride?

<p>Loop of Henle (C)</p> Signup and view all the answers

What is the main function of diuretics in the body?

<p>Enhance sodium and chloride secretion (D)</p> Signup and view all the answers

Which diuretic is considered less potent and more suitable for outpatient use?

<p>Hydrochlorothiazide (A)</p> Signup and view all the answers

What is the action of diuretics like furosemide on sodium and chloride in the body?

<p>Block reabsorption (A)</p> Signup and view all the answers

Which term refers to the condition of decreased urine output?

<p>Oliguria (D)</p> Signup and view all the answers

What effect does blocking Na and Cl reabsorption have on urine excretion?

<p>Increases urine production (C)</p> Signup and view all the answers

What is the mechanism of action of spironolactone in the context of diuretics?

<p>Inhibits the Na-K pump leading to increased potassium retention (B)</p> Signup and view all the answers

Which adverse effect is unique to loop diuretics like furosemide compared to other diuretics mentioned?

<p>Ototoxicity (C)</p> Signup and view all the answers

What is a common adverse effect experienced with triamterene, another potassium-sparing diuretic?

<p>Dizziness (C)</p> Signup and view all the answers

How does mannitol, an osmotic diuretic, differ from loop and potassium-sparing diuretics in terms of its mechanism of action?

<p>Creates an osmotic force without affecting Na and K (A)</p> Signup and view all the answers

Which diuretic is known for reducing intracranial pressure and intraocular pressure as part of its therapeutic uses?

<p>Mannitol (D)</p> Signup and view all the answers

What electrolyte imbalance is specifically associated with loop diuretics like furosemide?

<p>Hypokalemia (D)</p> Signup and view all the answers

Which drug interaction concern is unique to spironolactone among the mentioned diuretics?

<p>Increased risk of digoxin toxicity due to potassium depletion (C)</p> Signup and view all the answers

What caution should be exercised when administering triamterene related to its side effects?

<p>Renal or hepatic disease caution due to differing drug onset times (D)</p> Signup and view all the answers

What is the term for a solution that has a greater concentration than plasma?

<p>Hypertonic (D)</p> Signup and view all the answers

Which medication is used to treat high potassium levels by avoiding foods or medications containing K?

<p>Sodium polystyrene sulfonate (D)</p> Signup and view all the answers

In the context of fluid volume excess therapy, what is the primary effect of diuretics on Na and Cl reabsorption?

<p>Decrease Na and Cl reabsorption (C)</p> Signup and view all the answers

What is the main classification of diuretics that blocks Na and Cl in the loop of Henle and distal convoluted tubule?

<p>Thiazide diuretics (B)</p> Signup and view all the answers

Which term refers to a condition characterized by abnormally low urine output?

<p>Oliguria (D)</p> Signup and view all the answers

What percentage of water reabsorption occurs in tubular secretion?

<p>99% (B)</p> Signup and view all the answers

Which term describes a solution with a concentration less than that of plasma?

<p>Hypotonic (C)</p> Signup and view all the answers

What is the mechanism of action of spironolactone as a diuretic?

<p>Blocks aldosterone receptors (D)</p> Signup and view all the answers

Which electrolyte imbalance is NOT commonly associated with spironolactone use?

<p>Hypokalemia (C)</p> Signup and view all the answers

What is the unique adverse effect of triamterene among the mentioned diuretics?

<p>Endocrine effects (D)</p> Signup and view all the answers

Which drug interaction concern is common to triamterene and spironolactone as potassium-sparing diuretics?

<p>Electrolyte imbalances (D)</p> Signup and view all the answers

How does mannitol differ in mechanism of action compared to loop and potassium-sparing diuretics?

<p>Creates osmotic force (B)</p> Signup and view all the answers

Which condition is NOT listed among the therapeutic uses of loop diuretics like furosemide?

<p><strong>Hyponatremia</strong> (D)</p> Signup and view all the answers

What is a common adverse effect of loop diuretics like furosemide that sets them apart from potassium-sparing diuretics?

<p><strong>Hypokalemia</strong> (C)</p> Signup and view all the answers

What is the primary site of sodium absorption and diuretic action in the kidneys?

<p>Loop of Henle (B)</p> Signup and view all the answers

Which term describes a condition of abnormally low urine output?

<p>Oliguria (A)</p> Signup and view all the answers

What is the mechanism through which diuretics like furosemide impact urine excretion?

<p>Increasing Na excretion (C)</p> Signup and view all the answers

Which diuretic is less potent and more suitable for outpatient use?

<p>Hydrochlorothiazide (C)</p> Signup and view all the answers

What is the term for a solution that has a concentration greater than that of plasma?

<p>Hypertonic (A)</p> Signup and view all the answers

In the context of diuretics, what does the term 'nephron' primarily refer to?

<p>Reabsorption process (D)</p> Signup and view all the answers

What is the main classification of diuretics that blocks sodium and chloride in early reabsorption within the loop of Henle?

<p>Potassium-sparing diuretic (D)</p> Signup and view all the answers

Which electrolyte imbalance is NOT commonly associated with loop diuretics like furosemide?

<p>Hyperkalemia (C)</p> Signup and view all the answers

What is a common adverse effect associated with the potassium-sparing diuretic spironolactone?

<p>Hyperkalemia (A)</p> Signup and view all the answers

What is a unique adverse effect of triamterene among the mentioned diuretics?

<p>Hyperkalemia (C)</p> Signup and view all the answers

What electrolyte imbalance is specifically associated with spironolactone use?

<p>Hyperkalemia (D)</p> Signup and view all the answers

What is a common adverse effect experienced with mannitol, an osmotic diuretic?

<p>Headache (B)</p> Signup and view all the answers

What caution should be exercised when administering triamterene related to its side effects?

<p>Electrolyte monitoring (B)</p> Signup and view all the answers

Which drug interaction concern is common to triamterene and spironolactone as potassium-sparing diuretics?

<p>Digoxin toxicity (B)</p> Signup and view all the answers

What is the mechanism of action of spironolactone as a potassium-sparing diuretic?

<p>Inhibiting the Na/K exchange directly (A)</p> Signup and view all the answers

Which medication is known for reducing intracranial pressure and intraocular pressure among the listed diuretics?

<p>Mannitol (C)</p> Signup and view all the answers

What electrolyte imbalance is specifically associated with loop diuretics like furosemide?

<p>Hypokalemia (A)</p> Signup and view all the answers

Which diuretic directly inhibits Na/K exchange, causing side effects such as dizziness, headache, and diarrhea?

<p>Triamterene (A)</p> Signup and view all the answers

What is a unique endocrine effect associated with triamterene among the mentioned diuretics?

<p>Endocrine effects (C)</p> Signup and view all the answers

Which electrolyte imbalance is NOT commonly associated with spironolactone use?

<p>Hypokalemia (C)</p> Signup and view all the answers

What is a common adverse effect experienced with mannitol, an osmotic diuretic?

<p>Headache (B)</p> Signup and view all the answers

Which term describes a condition of abnormally high urine output?

<p>Polyuria (B)</p> Signup and view all the answers

What electrolyte imbalance is specifically associated with the use of sodium polystyrene sulfonate or dialysis for treating high potassium?

<p>Hyperkalemia (C)</p> Signup and view all the answers

Where does urine formation primarily involve filtrations, reabsorption, and tubular secretion?

<p>Kidneys (A)</p> Signup and view all the answers

What is the most suitable diuretic for outpatient use due to being less potent compared to others?

<p>Hydrochlorothiazide (A)</p> Signup and view all the answers

Which term refers to a solution that has a greater concentration than plasma?

<p>Hypertonic (B)</p> Signup and view all the answers

What effect does blocking Na and Cl reabsorption have on urine excretion?

<p>Increases urine excretion (C)</p> Signup and view all the answers

Which classification of diuretics blocks Na & Cl in the early reabsorption in the loop of Henle and distal convoluted tubule?

<p>Thiazide diuretic (D)</p> Signup and view all the answers

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