Cardiovascular System Overview

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Questions and Answers

What does LVEDV stand for and why is it significant in understanding heart function?

LVEDV stands for Left Ventricular End-Diastolic Volume, and it is significant because it represents the volume of blood in the left ventricle at the end of diastole, influencing ejection fraction and overall cardiac efficiency.

How does blood flow redistribution during exercise enhance skeletal muscle performance?

During exercise, blood flow is reduced to organs with lower activity, like the stomach and kidneys, allowing more blood to reach working muscles which have a higher demand for oxygen and nutrients.

What cardiovascular adaptations occur as a result of training that would lead to an increased stroke volume?

Training leads to increased ventricular volume, thicker ventricular walls due to hypertrophy, and improved force of contraction, all contributing to a higher stroke volume.

What is the normal range for ejection fraction (EF) and why is it an important measure?

<p>The normal range for ejection fraction (EF) is 55–70%, and it is important because it indicates the percentage of blood ejected from the left ventricle with each heartbeat, reflecting heart health and efficiency.</p> Signup and view all the answers

How does regular cardiovascular training affect heart rate at rest and during exercise?

<p>Regular cardiovascular training often results in decreased resting heart rate due to increased stroke volume, allowing the heart to pump more blood with fewer beats.</p> Signup and view all the answers

What is the main role of the myocardium in the heart?

<p>The myocardium is the heart muscle tissue responsible for contractions that pump blood.</p> Signup and view all the answers

How does a myocardial infarction occur?

<p>A myocardial infarction occurs when blood flow to part of the myocardium is blocked, leading to damage and potential death of the heart tissue.</p> Signup and view all the answers

What is the purpose of the heart valves?

<p>The heart valves ensure that blood flows only in one direction within the heart.</p> Signup and view all the answers

What happens during systole in the cardiac cycle?

<p>During systole, the atria contract to pump blood into the ventricles, which then contract to push blood into the lungs and the body.</p> Signup and view all the answers

Define blood pressure in terms of systolic and diastolic measurements.

<p>Blood pressure is the force exerted by circulating blood on the walls of blood vessels, measured by systolic pressure during ventricular contraction and diastolic pressure during heart rest.</p> Signup and view all the answers

What initiates the electrical activity of the heart?

<p>The electrical activity in the heart is initiated by the SA node, which sends signals through the atria.</p> Signup and view all the answers

What is the role of the P wave in an electrocardiogram?

<p>The P wave indicates the moment the SA node sends a signal that spreads through both atria.</p> Signup and view all the answers

What is the function of the intercalated discs in myocardium cells?

<p>Intercalated discs in myocardium cells allow for communication and the passing of signals between cells for synchronized contraction.</p> Signup and view all the answers

Describe the function of red blood cells.

<p>Red blood cells transport oxygen and nutrients throughout the body and carry carbon dioxide away for gas exchange.</p> Signup and view all the answers

Explain the role of the AV node during the cardiac cycle.

<p>The AV node acts as a critical relay point for electrical signals, introducing a 0.1-second delay before transmitting signals from the atria to the ventricles.</p> Signup and view all the answers

What causes the QRS complex in an electrocardiogram?

<p>The QRS complex occurs when the ventricles contract after the signal reaches them through the Purkinje fibers.</p> Signup and view all the answers

Explain the skeletal muscle pump and its importance in venous return.

<p>The skeletal muscle pump helps in venous return by increasing pressure in the veins when muscles contract, pushing blood back to the heart.</p> Signup and view all the answers

How does preload affect stroke volume according to the Frank-Starling law?

<p>Preload increases stroke volume by allowing the myocardium in the left ventricle to stretch, leading to a more forceful contraction.</p> Signup and view all the answers

Define cardiac output and how it is calculated.

<p>Cardiac output is the total volume of blood pumped by the heart per minute, calculated by multiplying heart rate (HR) by stroke volume (SV).</p> Signup and view all the answers

What is the role of epinephrine in regulating heart function during exercise?

<p>Epinephrine increases the availability of calcium in the blood, enhancing the strength of ventricular contractions.</p> Signup and view all the answers

What impact does venoconstriction have during exercise?

<p>Venoconstriction increases venous return to the heart by constricting veins when more blood is needed during exercise.</p> Signup and view all the answers

What is the primary function of systemic circulation?

<p>The primary function of systemic circulation is to deliver oxygenated blood from the heart to the rest of the body and return deoxygenated blood back to the heart.</p> Signup and view all the answers

Describe the pathway of deoxygenated blood during pulmonary circulation.

<p>Deoxygenated blood enters the heart from the superior and inferior vena cava, goes into the right atrium, passes through the tricuspid valve into the right ventricle, and is pumped into the pulmonary artery to reach the lungs.</p> Signup and view all the answers

What is coronary circulation and why is it important?

<p>Coronary circulation refers to the blood supply to the heart muscle itself, delivering oxygen and nutrients essential for its function.</p> Signup and view all the answers

How does the body respond to increased oxygen demands during exercise?

<p>The body responds by increasing heart rate (HR) and stroke volume (SV), which together raise cardiac output (Q) to meet the heightened oxygen demand.</p> Signup and view all the answers

Explain what cardiovascular drift is during prolonged exercise.

<p>Cardiovascular drift refers to the phenomenon where stroke volume decreases slightly and heart rate increases to maintain cardiac output during prolonged exercise.</p> Signup and view all the answers

During exercise, how is blood flow redistributed in the body?

<p>Blood flow to the muscles increases from 15-20% of cardiac output at rest to 80-85% at maximum exercise, while flow to organs like the liver and kidneys is reduced.</p> Signup and view all the answers

What happens to stroke volume and heart rate as a person reaches their VO2 max during exercise?

<p>At VO2 max, stroke volume may plateau while heart rate continues to increase, leading to an overall increase in cardiac output.</p> Signup and view all the answers

Why do we call the heart a double pump?

<p>The heart is referred to as a double pump because it has two distinct circuits: one for systemic circulation and another for pulmonary circulation.</p> Signup and view all the answers

Flashcards

Systemic Circulation

The circulation that delivers oxygenated blood from the heart to the body and returns deoxygenated blood back to the heart.

Pulmonary Circulation

The circulation that carries deoxygenated blood from the heart to the lungs for oxygenation and returns oxygenated blood back to the heart.

Coronary Circulation

The system of blood vessels that supplies blood to the heart muscle itself.

Cardiac Output (Q)

The amount of blood pumped by the heart per minute.

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How body responds to ↑ oxygen demands in muscle during exercise.

The increase in heart rate and stroke volume during exercise, leading to increased cardiac output.

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Cardiovascular Drift

A decrease in stroke volume during prolonged exercise, while heart rate increases to maintain cardiac output.

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Redistribution of Blood Flow

The redirection of blood flow during exercise, where blood flow to muscles increases and blood flow to other organs decreases.

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Why do we call the heart a double pump?

The heart acts as a double pump because it has two separate circuits: the systemic circulation and the pulmonary circulation.

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What does the P wave on an ECG represent?

The P wave on an electrocardiogram represents the electrical impulse generated by the SA node, spreading through both atria, causing them to contract.

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What does the QRS complex on an ECG represent?

The QRS complex represents the electrical activity during ventricular contraction, as the signal travels through the Purkinje fibers.

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What does the T wave on an ECG represent?

The T wave on an ECG represents the electrical activity associated with the repolarization of the ventricles, as they relax and prepare for the next contraction.

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What is the primary function of red blood cells (RBCs)?

Red blood cells are responsible for carrying oxygen from the lungs to the body's tissues and carbon dioxide back to the lungs for exhalation.

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How does the skeletal muscle pump contribute to venous return?

The skeletal muscle pump helps return blood to the heart by squeezing veins when muscles contract, increasing pressure and pushing blood upward.

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How does the thoracic pump assist venous return?

The thoracic pump assists venous return by creating a pressure difference between the chest and abdominal cavities during breathing, pushing blood upwards.

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How does venoconstriction help with venous return?

Venoconstriction, triggered by the nervous system during exercise, helps increase venous return by narrowing veins and pushing blood towards the heart.

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Explain the Frank-Starling Law in terms of stroke volume.

The Frank-Starling law states that the stronger the myocardial stretch during diastole (preload), the more forceful the subsequent ventricular contraction.

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What is Myocardium?

The heart muscle tissue responsible for contraction and blood pumping. It's involuntary, striated, and activated by calcium and the sliding filament theory.

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What is a Myocardial Infarction?

A heart attack occurs when blood flow to the myocardium is blocked, causing tissue damage and death due to lack of oxygen. It's often caused by fatty plaque buildup in the coronary arteries, leading to a clot that blocks blood flow.

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What is the Path of Blood Flow in the Heart?

The flow of blood through the heart, starting with the deoxygenated blood entering the right atrium, then pumps to the right ventricle to the lungs for oxygenation. The oxygenated blood returns to the left atrium, then pumps to the left ventricle, and finally to the systemic circulation.

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What is the function of valves in the heart?

Valves in the heart ensure one-directional blood flow. AV valves (tricuspid & bicuspid) prevent backflow between atria and ventricles during ventricular contraction. Semilunar valves (pulmonary & aortic) close when blood is pumped out during ventricular relaxation. Leaky valves cause murmurs.

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What is Ventricular Systole?

Refers to the contraction phase of the heart muscle, when the ventricles pump blood into the pulmonary arteries and aorta. It's regulated by the SA node and lasts for about 0.3 seconds. During this phase, the semilunar valves close.

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What is Ventricular Diastole?

Refers to the relaxation phase of the heart muscle, when the ventricles fill with blood from the atria. It's regulated by the AV node and lasts for about 0.5 seconds. During this phase, the AV valves close.

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How does the heart's electrical activity initiate contraction?

The electrical activity of the heart originates in the sinoatrial (SA) node, which acts as the pacemaker. The signal travels through the atria, causing them to contract. The signal then reaches the atrioventricular (AV) node, where it's briefly delayed before moving to the ventricles via the Bundle of His and Purkinje fibers, causing ventricular contraction.

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What is the difference between Systolic and Diastolic blood pressure?

The force of blood pushing against the walls of the arteries when the heart contracts (systole) is called systolic blood pressure. The pressure when the heart is at rest (diastole) is called diastolic blood pressure.

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What is LVEDV?

The volume of blood in the left ventricle at the end of diastole (relaxation phase). It indicates how much blood is available to be pumped out with each heartbeat.

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What is Ejection Fraction (EF)?

The percentage of blood pumped out of the left ventricle with each heartbeat. It measures the heart's efficiency in ejecting blood.

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How does blood flow change during exercise?

During exercise, the body prioritizes blood flow to working muscles, reducing blood flow to other organs like the stomach and kidneys. This ensures that the muscles receive adequate oxygen and nutrients for increased activity.

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What are the cardiovascular effects of training?

Training increases the heart's size and strength, improving its ability to pump blood. This leads to a larger stroke volume, meaning more blood is pumped with each beat, and a lower resting heart rate.

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How does training affect blood volume?

Increased blood volume, especially in the red blood cells, is a positive adaptation to training. This allows for better oxygen transport throughout the body.

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Study Notes

Cardiovascular System

  • Systemic Circulation: Delivers oxygenated blood from the heart to the body and returns deoxygenated blood to the heart.

    • Oxygenated blood enters the left atrium through pulmonary veins.
    • The blood then passes through the bicuspid valve and is pumped from the left ventricle to the aorta and then to the arteries to the body.
  • Pulmonary Circulation: Carries deoxygenated blood from the body to the heart to the lungs for oxygenation, and returns oxygen-rich blood to the heart.

    • Deoxygenated blood enters the heart through the superior and inferior vena cava into the right atrium.
    • It then moves into the right ventricle through the tricuspid valve, and is pumped into the pulmonary artery.
    • The blood travels to the lungs, goes through gas exchange (Co2 for O2 in alveoli) and returns to the heart.
  • Coronary Circulation: The system of blood vessels that supplies blood to the heart muscle (myocardium).

    • Oxygenated blood flows to the heart through coronary arteries which branch off the aorta.
    • The blood delivers O2 through capillary beds.
    • Deoxygenated blood returns via cardiac veins to the right atrium.

Changes in Cardiac Output During Exercise

  • Heart rate (HR) and stroke volume (SV) increase with the intensity of exercise. This leads to an increased cardiac output (Q).
  • In untrained individuals, HR and Q plateau at the maximal oxygen uptake (VO2 max).
  • With higher intensity exercise, SV increases because of higher systolic pressure and lower peripheral resistance.
  • Prolonged exercise can lead to cardiovascular drift, where SV decreases slightly as heart rate increases.
    • Increased body temperature leads to dehydration and lower plasma volume.
    • This leads to reduced venous return to the heart.
    • If below lactate threshold, a steady state level should be reached within 1-4 minutes.

Redistribution of Blood Flow

  • Blood flow to muscles increases from 15-20% at rest to 80–85% during maximal exercise.
  • Blood flow to other organs like the liver, kidneys, and skin is reduced.

Myocardium

  • The heart muscle tissue is involuntary and striated.
  • Cells are connected by intercalated discs, allowing for coordinated contractions.
  • Calcium ions and sliding filament theory activate the muscle contractions.

Myocardial Infarction (Heart Attack)

  • When blood flow to the heart muscle cannot reach the demand, the tissues begin to damage and die from lack of oxygen.
  • Fatty plaque buildup in coronary arteries causes blockages and blood flow interruption.

Path of Blood Flow Through the Heart

The blood circulates through the heart using specific valves and chambers to ensure one-way flow. This process is regulated by the conductive system of the heart.

Cardiac Cycle

  • Systole: Atrial and ventricular contractions that pump blood. It takes approximately 0.5 seconds. Atria contract first, followed by ventricles, pumping blood forward.
  • Diastole: Relaxation phase between contractions, lasting about 0.3 seconds. The heart fills with blood.

Electrical Activity in the Heart

  • The sinoatrial (SA) node initiates the heartbeat.
  • The signal travels through the atria, causing them to contract.
  • The atrioventricular (AV) node then transmits the signal to the ventricles.
  • The signal travels through the bundle of His and Purkinje fibers, causing the ventricles to contract .

Conductive Pathway and Electrocardiogram (ECG)

  • P wave: SA node signal spreads through the atria
  • QRS complex: Ventricular contraction
  • T wave: Ventricles relax

Blood Functions

  • Transport oxygen and nutrients
  • Regulate temperature and pH
  • Distribute heat throughout the body.

Blood Components

  • Plasma
  • Red blood cells (RBCs)
  • White blood cells (WBCs)

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