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Questions and Answers
What are the indications for Cardizem/diltiazem? (Select all that apply)
What are the indications for Cardizem/diltiazem? (Select all that apply)
- Angina pectoris (correct)
- Vasospastic (Prinzmetal's) angina (correct)
- Hypertension (correct)
- Asthma
What is the primary action of Cardizem/diltiazem?
What is the primary action of Cardizem/diltiazem?
Inhibits transport of calcium into myocardial and vascular smooth muscle cells.
Which of the following are contraindications for using Cardizem/diltiazem? (Select all that apply)
Which of the following are contraindications for using Cardizem/diltiazem? (Select all that apply)
- Ventricular tachycardia
- Hypersensitivity (correct)
- Sick sinus syndrome (correct)
- 2nd- or 3rd-degree AV block (correct)
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Study Notes
Indications for Diltiazem
- Used to treat hypertension, angina pectoris, and vasospastic (Prinzmetal's) angina.
- Effective in managing supraventricular tachyarrhythmias and rapidly controlling ventricular rates in atrial flutter or fibrillation.
Mechanism of Action
- Inhibits calcium transport into myocardial and vascular smooth muscle cells.
- This action reduces excitation-contraction coupling, thereby decreasing cardiac contraction strength.
- Leads to systemic vasodilation, which lowers blood pressure.
- Promotes coronary vasodilation, reducing the frequency and severity of angina attacks.
- Aids in the reduction of ventricular rate during atrial fibrillation or flutter.
Contraindications and Precautions
- Contraindicated in individuals with hypersensitivity to the drug.
- Not recommended for patients with sick sinus syndrome or 2nd- or 3rd-degree AV blocks unless an artificial pacemaker is present.
- Caution is advised in patients with low systolic blood pressure.
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