12 Questions
Which factor is responsible for the formation of a hemostatic plug that seals the vessel wall and prevents further blood loss?
Platelet adherence
What is responsible for enhancing platelet aggregation in the coagulation cascade?
Thrombin
Which condition is associated with venous stasis?
Heart failure
What is the FDA-approved use of Warfarin?
Prevention and treatment of VTE
Which mechanism does Warfarin use to exert its anticoagulant effect?
Inhibiting production of clotting factors II, VII, IX, X, proteins C and S
What is a contraindication for Warfarin therapy?
Pregnancy/postpartum
Which cellular materials compose a thrombus?
Red and white blood cells, platelets
What is the common manifestation of clot formation in the venous circulation?
Pulmonary embolism (PE)
Which factor does Unfractionated heparin (UFH) inhibit to prevent clot formation?
Factor IIa (thrombin)
What condition is a contraindication for the use of Unfractionated heparin (UFH)?
Severe thrombocytopenia
What should be done if major bleeding occurs during Unfractionated heparin (UFH) therapy?
Discontinue therapy immediately and start IV protamine sulfate infusion over 10 minutes
What does heparin-induced inhibition of thrombin-induced activation of factor VIII result in?
Inhibition of further clot formation
Test your knowledge about deep vein thrombosis (DVT), pulmonary embolism (PE), and the factors involved in clot formation in the venous circulation. Learn about the composition of thrombus and the role of UFH-antithrombin complex in inhibiting thrombus activity.
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