Cardiovascular Disease and Thrombosis Quiz
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Questions and Answers

Which factor is responsible for the formation of a hemostatic plug that seals the vessel wall and prevents further blood loss?

  • Tissue plasminogen activator evaluation
  • Fibrinolysis facilitation
  • Platelet adherence (correct)
  • Activation of the coagulation cascade

What is responsible for enhancing platelet aggregation in the coagulation cascade?

  • Fibrin production
  • Factors V and VIII activation
  • Thrombin (correct)
  • Tissue plasminogen activator

Which condition is associated with venous stasis?

  • Pregnancy/postpartum
  • Excess of factor VIII or XI
  • Indwelling venous catheters
  • Heart failure (correct)

What is the FDA-approved use of Warfarin?

<p>Prevention and treatment of VTE (D)</p> Signup and view all the answers

Which mechanism does Warfarin use to exert its anticoagulant effect?

<p>Inhibiting production of clotting factors II, VII, IX, X, proteins C and S (B)</p> Signup and view all the answers

What is a contraindication for Warfarin therapy?

<p>Pregnancy/postpartum (C)</p> Signup and view all the answers

Which cellular materials compose a thrombus?

<p>Red and white blood cells, platelets (B)</p> Signup and view all the answers

What is the common manifestation of clot formation in the venous circulation?

<p>Pulmonary embolism (PE) (B)</p> Signup and view all the answers

Which factor does Unfractionated heparin (UFH) inhibit to prevent clot formation?

<p>Factor IIa (thrombin) (C)</p> Signup and view all the answers

What condition is a contraindication for the use of Unfractionated heparin (UFH)?

<p>Severe thrombocytopenia (C)</p> Signup and view all the answers

What should be done if major bleeding occurs during Unfractionated heparin (UFH) therapy?

<p>Discontinue therapy immediately and start IV protamine sulfate infusion over 10 minutes (B)</p> Signup and view all the answers

What does heparin-induced inhibition of thrombin-induced activation of factor VIII result in?

<p>Inhibition of further clot formation (A)</p> Signup and view all the answers

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