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Questions and Answers
What is the main characteristic of atherosclerosis?
What is the main characteristic of atherosclerosis?
Deposits of fatty substances, cholesterol, cellular waste products, calcium, and fibrin in the inner lining of the artery.
What is ischemia in the context of angina?
What is ischemia in the context of angina?
Reduction of the heart’s blood and oxygen supply.
What happens to the heart during a myocardial infarction?
What happens to the heart during a myocardial infarction?
The blood supply to the heart is disrupted, causing damage to the heart.
What is a possible complication of congestive heart failure?
What is a possible complication of congestive heart failure?
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What is an irregularity in heart rhythm known as?
What is an irregularity in heart rhythm known as?
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What is the name of the condition that occurs when a blood clot is dislodged and moves through the circulatory system?
What is the name of the condition that occurs when a blood clot is dislodged and moves through the circulatory system?
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What is a possible cause of damage to the heart muscle leading to congestive heart failure?
What is a possible cause of damage to the heart muscle leading to congestive heart failure?
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What is the approximate percentage of people who do not survive their first heart attack?
What is the approximate percentage of people who do not survive their first heart attack?
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What is bradycardia, and what is its effect on the heart?
What is bradycardia, and what is its effect on the heart?
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What is fibrillation, and how does it affect the heart?
What is fibrillation, and how does it affect the heart?
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What is congenital heart disease, and how common is it?
What is congenital heart disease, and how common is it?
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What is rheumatic heart disease, and what causes it?
What is rheumatic heart disease, and what causes it?
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What are some common symptoms of heart disease?
What are some common symptoms of heart disease?
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What is a lipid profile, and what does it typically include?
What is a lipid profile, and what does it typically include?
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What is a high level of cholesterol associated with?
What is a high level of cholesterol associated with?
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What is the function of LDL cholesterol, and what is its effect on the heart?
What is the function of LDL cholesterol, and what is its effect on the heart?
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What is the function of creatine kinase (CK) in cardiac muscles?
What is the function of creatine kinase (CK) in cardiac muscles?
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What is the significance of CK-MB isoenzyme in diagnosing acute myocardial infarction (AMI)?
What is the significance of CK-MB isoenzyme in diagnosing acute myocardial infarction (AMI)?
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What is the limitation of lactate dehydrogenase (LDH) as a biomarker for myocardial infarction?
What is the limitation of lactate dehydrogenase (LDH) as a biomarker for myocardial infarction?
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How do cardiac troponin T and I (cTnT and cTnI) differ from other cardiac enzymes in diagnosing myocardial infarction?
How do cardiac troponin T and I (cTnT and cTnI) differ from other cardiac enzymes in diagnosing myocardial infarction?
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What is the significance of cardiac biomarkers in diagnosing myocardial infarction?
What is the significance of cardiac biomarkers in diagnosing myocardial infarction?
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How do conventional ECG changes differ from troponin levels in diagnosing myocardial infarction?
How do conventional ECG changes differ from troponin levels in diagnosing myocardial infarction?
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What is the role of myoglobin in diagnosing myocardial infarction?
What is the role of myoglobin in diagnosing myocardial infarction?
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What is the significance of cardiac enzymes in diagnosing myocardial infarction?
What is the significance of cardiac enzymes in diagnosing myocardial infarction?
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Study Notes
Types of Cardiovascular Disease
- Atherosclerosis: characterized by deposits of fatty substances, cholesterol, cellular waste products, calcium, and fibrin in the inner lining of the artery
- Coronary heart disease: includes acute myocardial infarction (heart attack), angina (chest pain), and congestive heart failure (CHF)
- Arrhythmia: irregular heart beat
- Congenital and rheumatic heart disease: can affect children and result from hereditary factors, maternal diseases, or chemical intake during fetal development
Atherosclerosis
- Characterized by hyperlipidemia (abnormally high blood lipid level) and plaque (build-up of cholesterol deposits in the arteries)
Angina
- Ischemia: reduction of the heart's blood and oxygen supply
- Can lead to severe pain, a sign of myocardial infarction (MI)
Myocardial Infarction (Heart Attack)
- Blood supply to the heart is disrupted, causing damage to the heart
- May cause irregular heart beat or stop altogether
- Can be similar to stroke
- 25% of people do not survive their first heart attack
Congestive Heart Failure (CHF)
- Damaged or overworked heart muscle is unable to keep blood circulating normally
- Can result from rheumatic fever, pneumonia, or other cardiovascular problems
- Lack of proper circulation can lead to blood accumulation in the vessels of the legs, ankles, or lungs
Arrhythmias
- Irregularity in heart rhythm
- Tachycardia: racing heart in the absence of exercise or anxiety
- More sensitive biochemical markers, such as troponins, can be released in some patients without conventional ECG changes of infarction
Cardiac Markers
- Cardiac enzymes: creatine kinase (CK), lactate dehydrogenase (LDH), serum aspartate aminotransferase (AST) or serum glutamate transaminase (SGOT)
- Cardiac proteins: cardiac troponin T and I (cTnT and cTnI), myoglobin
Creatine Kinase (CK)
- Enzyme expressed in multiple tissues, including cardiac and muscle tissues
- Function: catalyzes the conversion of creatine to phosphocreatine, degrading ATP to ADP
- CK-MB isoenzyme: increases 4 hours after acute myocardial infarction (AMI), reaches maximum peak within 12-24 hours, and returns to normal after 2-3 days of onset
Lactate Dehydrogenase (LDH)
- Distributed widely in liver, cardiac muscle, kidney, skeletal muscle, erythrocytes, and other tissues
- Non-specific marker, but can be used to diagnose myocardial infarction (MI)
Symptoms of Heart Disease
- Fatigue, weakness, shortness of breath, dizziness, palpitations, chest discomfort and/or pain, chest heaviness, nausea, vomiting, and pain that radiates to the jaw, arm, or throat
- Sometimes heart disease causes no symptoms at all
Lipid Profiles
- Includes levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), very low-density lipoprotein cholesterol (VLDL-C), triglycerides (TG), and atherogenic ratio (LDL-C/HDL-C)
- Used to determine risk of heart disease
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Description
This quiz covers the basics of cardiovascular disease, including symptoms, risk factors, and diagnostic tests such as lipid profiles and cardiac markers. Topics include atherosclerosis, coronary heart disease, angina, and more.