Podcast
Questions and Answers
What is the clinical significance of the ventilation/perfusion (V/Q) ratio in respiratory physiology?
What is the clinical significance of the ventilation/perfusion (V/Q) ratio in respiratory physiology?
- It solely assesses lung compliance.
- It has no impact on overall lung health.
- It primarily evaluates lung tissue elasticity.
- It determines the efficiency of gas exchange in the lungs. (correct)
How does the distribution of ventilation and perfusion differ between the apex and the base of the lungs?
How does the distribution of ventilation and perfusion differ between the apex and the base of the lungs?
- Ventilation and perfusion are equally distributed throughout the lungs.
- Ventilation is greater at the apex than the base, while perfusion is equal.
- Both ventilation and perfusion are greater at the apex than the base.
- Ventilation is lower at the apex compared to the base, while perfusion is greater. (correct)
What is the mechanism of hypoxic pulmonary vasoconstriction?
What is the mechanism of hypoxic pulmonary vasoconstriction?
- It leads to vasodilation of pulmonary arteries to increase blood flow.
- It enhances blood flow to well-ventilated areas to optimize gas exchange. (correct)
- It is a response that occurs only in children.
- It has no physiological relevance in adults.
In a case where an adult patient shows reduced air entry and accumulation of secretion in the right lung, how should the patient be positioned?
In a case where an adult patient shows reduced air entry and accumulation of secretion in the right lung, how should the patient be positioned?
When treating an infant with similar respiratory issues, how should the positioning differ from that of an adult, and why?
When treating an infant with similar respiratory issues, how should the positioning differ from that of an adult, and why?
What is a potential consequence of administering excessive supplementary oxygen therapy?
What is a potential consequence of administering excessive supplementary oxygen therapy?
Which of the following best describes the Haldane effect?
Which of the following best describes the Haldane effect?
Why is positioning important in respiratory physiotherapy for infants?
Why is positioning important in respiratory physiotherapy for infants?
In adults, what influences the decision for patient positioning during respiratory therapy?
In adults, what influences the decision for patient positioning during respiratory therapy?
How does the perfusion gradient help in respiratory physiotherapy?
How does the perfusion gradient help in respiratory physiotherapy?
What factor might exacerbate V/Q mismatch during supplementary oxygen therapy?
What factor might exacerbate V/Q mismatch during supplementary oxygen therapy?
What is the primary reason for the variation in positioning effects between infants and adults?
What is the primary reason for the variation in positioning effects between infants and adults?
In the context of ventilation and perfusion, what does V/Q stand for?
In the context of ventilation and perfusion, what does V/Q stand for?
Which of the following is a caution when providing supplementary oxygen therapy?
Which of the following is a caution when providing supplementary oxygen therapy?
What physiological aspect must be monitored due to its role in ventilation and perfusion?
What physiological aspect must be monitored due to its role in ventilation and perfusion?
Flashcards
Ventilation-Perfusion (V/Q) mismatch
Ventilation-Perfusion (V/Q) mismatch
A situation where the amount of air reaching the alveoli (ventilation) is not balanced with the blood flow to those alveoli (perfusion).
Hypoxic drive
Hypoxic drive
The body's use of low blood oxygen levels to stimulate breathing.
Supplementary oxygen therapy
Supplementary oxygen therapy
Providing supplemental oxygen to a patient beyond what can be achieved through normal breathing.
V/Q mismatch reversal
V/Q mismatch reversal
Shifting the imbalance in ventilation and perfusion, potentially worsened by supplemental oxygen.
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Haldane effect
Haldane effect
The process where the bond between hemoglobin and carbon dioxide influences the lungs' ability to bind or release oxygen.
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Positioning in adults
Positioning in adults
Varying position alters perfusion gradients impacting secretion drainage and oxygenation.
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Positioning in infants
Positioning in infants
Infants have compliant rib cages; dependent positioning compresses chest hindering drainage.
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Perfusion gradient
Perfusion gradient
Differences in blood flow and oxygenation across the lung; dependent positioning.
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Ventilation gradient
Ventilation gradient
Differences in air flow reaching the lungs; dependent positioning.
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Non-dependent lung
Non-dependent lung
Portion of the lung at the upper part of the body; potentially better oxygenated.
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V/Q ratio
V/Q ratio
The ratio of ventilation (air flow) to perfusion (blood flow) in the lungs.
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Ventilation/Perfusion (V/Q) mismatch at the lung apex
Ventilation/Perfusion (V/Q) mismatch at the lung apex
Ventilation (bringing air in) is less than perfusion (blood flow) at the apex of the lungs. This results in lower V/Q.
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Ventilation/Perfusion (V/Q) mismatch at the lung base
Ventilation/Perfusion (V/Q) mismatch at the lung base
Ventilation (bringing air in) is greater than perfusion (blood flow) at the base of the lungs. This results in higher V/Q.
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Hypoxic pulmonary vasoconstriction
Hypoxic pulmonary vasoconstriction
A process where blood vessels in the lungs constrict in response to low levels of oxygen. This helps to direct blood flow to well-ventilated areas of the lungs.
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Positioning patient with lung secretions
Positioning patient with lung secretions
Position the patient with the affected lung in the dependent position to facilitate drainage of secretions.
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Cardiopulmonary Physiotherapy - Review of Respiratory Physiology II: Ventilation and Perfusion
- The lecture covers respiratory physiology, specifically ventilation and perfusion.
- Learning objectives include defining the ventilation/perfusion (V/Q) ratio, explaining regional differences in ventilation and perfusion of the lungs, illustrating V/Q matching and mismatch, describing regulatory mechanisms responding to disturbed V/Q ratios, applying the concept of ventilation and perfusion to clinical decision-making for adults and pediatric patients with respiratory dysfunction, and understanding the different aspects of V/Q ratio.
- Gas exchange is crucial and happens at the alveoli level. Oxygen and carbon dioxide diffuse across the respiratory membrane. Key factors are the partial pressures of oxygen and carbon dioxide in the alveoli and pulmonary capillaries.
- Ventilation is the movement of air in and out of the lungs. Minute ventilation (VE) is the volume of air that enters or leaves the lungs per minute. Tidal volume (VT) is the volume of air inhaled or exhaled in a single breath. Respiratory rate (f) is the number of breaths per minute.
- The formula for minute ventilation (VE) is: VE = f x VT
- Typical values for adults at rest are f = 12 breaths/minute and VT = 500 mL. Children's values vary from 3 to 5 mL/kg.
- Lung volumes and capacities include inspiratory reserve volume (IRV), tidal volume (VT), expiratory reserve volume (ERV), residual volume (RV), vital capacity (VC), functional residual capacity (FRC), and total lung capacity (TLC).
- Anatomical dead space is the air in the conducting passages that does not reach the alveoli. Alveolar dead space is air reaching alveoli but not participating in gas exchange due to insufficient blood supply. Physiological dead space is the combined anatomical and alveolar dead space.
- Alveolar ventilation is the amount of minute ventilation reaching the respiratory zone used for gas exchange.
- The formula for alveolar ventilation is: Alveolar ventilation = (Tidal volume – anatomical dead space) x Respiratory rate
- Hyperventilation and hypoventilation are deviations from normal ventilation.
- Hypoventilation results in poor CO2 excretion, leading to respiratory acidosis. Causes include respiratory depression, respiratory muscle weakness, infection, consolidation, or atelectasis, and COPD.
- Hyperventilation leads to excessive CO2 excretion and respiratory alkalosis. Possible causes include anxiety, metabolic disease (like hyperthyroidism), and high altitude.
- The V/Q ratio describes the ratio of ventilation to perfusion. Normal value in healthy people is 0.8 representing 4 liters of ventilation per minute, and 5 liters of perfusion.
- V/Q matching is effective ventilation matched with blood supply from pulmonary capillaries.
- V/Q mismatch is an imbalance between ventilation and perfusion. This occurs when ventilation or perfusion is inadequate or uneven in different parts of the lungs.
- Consequences of V/Q mismatch include inadequate oxygenation of blood and CO2 removal.
- Hypoxic pulmonary vasoconstriction (HPV) is an automatic response to low oxygen, to redirect blood flow to areas of the lung with good ventilation.
- The mechanism is controlled by smooth muscle cells in pulmonary arterioles and is sensitive to alveolar PO2.
- Autoregulating homeostatic mechanisms in the lungs adjust pulmonary arterioles and bronchioles to match ventilation and perfusion. Hypoxia is a key stimulus.
- Clinical implications of ventilation-perfusion imbalances in patient care, including positioning for adults and infants, are crucial for optimal treatment outcomes. COPD patients necessitate special care.
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