Cardiomyopathy and Myocarditis: Definition and Classification

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Questions and Answers

Which term is used to describe diffuse dysfunction attributed to multivessel coronary artery disease?

  • Restrictive cardiomyopathy
  • Dilated cardiomyopathy
  • Hypertrophic cardiomyopathy
  • Ischemic cardiomyopathy (correct)

What are cardiomyopathies characterized by?

  • Morphologically and functionally normal myocardium
  • Abnormal myocardium in the presence of other diseases
  • Genetic disease (correct)
  • Structural heart disease

What was the traditional classification of cardiomyopathies based on?

  • Echocardiographic findings
  • Symptoms reported by patients
  • Autopsy specimens (correct)
  • Electrocardiographic findings

Which term is used to describe cardiomyopathy resulting from causes other than multivessel coronary artery disease?

<p>Hypertrophic cardiomyopathy (B)</p> Signup and view all the answers

What term is sometimes applied to describe diffuse dysfunction attributed to multivessel coronary artery disease?

<p>Ischemic cardiomyopathy (D)</p> Signup and view all the answers

Which cardiomyopathy is now defined more on the basis of abnormal diastolic function?

<p>Restrictive cardiomyopathy (C)</p> Signup and view all the answers

Why is the classification scheme based on phenotype considered increasingly inadequate?

<p>All of the above (D)</p> Signup and view all the answers

Which term primarily describes the resulting syndrome of fluid retention in cardiomyopathy?

<p>Congestive heart failure (C)</p> Signup and view all the answers

What may be absent despite severe fluid retention in younger patients with cardiomyopathy?

<p>Peripheral edema (A)</p> Signup and view all the answers

What is the primary presentation for fulminant myocarditis?

<p>Acute cardiogenic shock (A)</p> Signup and view all the answers

Which imaging modality is increasingly used to provide further information on myocardial tissue characterization?

<p>MRI (A)</p> Signup and view all the answers

Which type of inheritance pattern is most commonly seen in familial cardiomyopathies?

<p>Autosomal dominant (D)</p> Signup and view all the answers

What kind of genetic mutations are the most common in cardiomyopathy?

<p>Truncating variants (B)</p> Signup and view all the answers

How do missense mutations affect the normal allele in cardiomyopathy?

<p>Interfere with normal allele through a dominant negative mechanism (D)</p> Signup and view all the answers

What is haploinsufficiency in the context of cardiomyopathy?

<p>Lack of a stable protein causing disease (C)</p> Signup and view all the answers

Which type of mutations may create a truncated or unstable protein in cardiomyopathy?

<p>Nonsense mutations (B)</p> Signup and view all the answers

What characterizes genetic cardiomyopathy in terms of penetrance?

<p>Age-dependent and incomplete penetrance (A)</p> Signup and view all the answers

How does sex influence penetrance and clinical severity in most cardiomyopathies?

<p>Greater in men (B)</p> Signup and view all the answers

In which type of mutation is the lack of a stable protein the cause of cardiomyopathy?

<p>&quot;Haploinsufficiency&quot; mutations (C)</p> Signup and view all the answers

What is a possible consequence of antiviral drugs used to treat chronic HIV?

<p>Lymphocytic myocarditis (A)</p> Signup and view all the answers

In which regions has hepatitis C been particularly associated with cardiomyopathy?

<p>Germany and Asia (C)</p> Signup and view all the answers

What factor can complicate the clinical picture related to cardiomyopathy when treating chronic HIV?

<p>Pericardial effusions (D)</p> Signup and view all the answers

What effect can interferon therapy have on cardiac function?

<p>Improvement (B)</p> Signup and view all the answers

Which viruses have been specifically implicated in myocarditis, besides hepatitis viruses?

<p>Mumps and respiratory syncytial virus (A)</p> Signup and view all the answers

What is the dominant injury site of SARS-CoV-2, leading to severe complications?

<p>Lungs (D)</p> Signup and view all the answers

Which cytokine is mentioned as possibly depressing cardiac function transiently?

<p>Interferon (D)</p> Signup and view all the answers

Which family of RNA viruses was first implicated in causing clinical myocarditis in humans?

<p>Picornaviruses (C)</p> Signup and view all the answers

Which of the following DNA viruses is well recognized to cause myocarditis and is also common in the healthy population?

<p>Adenovirus (C)</p> Signup and view all the answers

Which virus may affect the cardiovascular system through infection of vascular endothelial cells?

<p>Parvovirus B19 (B)</p> Signup and view all the answers

Which virus was associated with an incidence of dilated cardiomyopathy (DCM) of 1–2% before the advent of highly active antiretroviral therapy?

<p>Human immunodeficiency virus (HIV) (B)</p> Signup and view all the answers

Which virus has been associated with a lower incidence of cardiac disease due to the advent of highly active antiretroviral therapy?

<p>Human immunodeficiency virus (HIV) (B)</p> Signup and view all the answers

Which technique detects viral genomes in the majority of patients with dilated cardiomyopathy (DCM)?

<p>Polymerase chain reaction (PCR) (A)</p> Signup and view all the answers

Which of the following viruses may contribute to chronic cardiomyopathy despite serologic evidence of exposure in many children and most adults?

<p>Parvovirus B19 (D)</p> Signup and view all the answers

What is a common feature of Chagas' disease related to the conduction system abnormalities?

<p>Atrial fibrillation (C)</p> Signup and view all the answers

Why is xenodiagnosis rarely performed in Chagas' disease diagnosis?

<p>Low specificity and sensitivity (B)</p> Signup and view all the answers

Which medication is commonly used to treat heart failure manifestations in advanced stages of Chagas' disease?

<p>Heart failure medications (C)</p> Signup and view all the answers

What is a known side effect of the antiparasitic therapies benznidazole and nifurtimox?

<p>Neuropathy (D)</p> Signup and view all the answers

Why was the role of antiparasitic therapy left unclear in the trial with adults having Chagas' cardiomyopathy?

<p>Disease progression continued despite treatment (D)</p> Signup and view all the answers

What makes the dilated ventricles in Chagas' disease particularly thrombogenic?

<p>Common occurrence of ventricular aneurysms (C)</p> Signup and view all the answers

Why are two separate positive serologic tests needed to diagnose Chagas' disease?

<p>Low specificity and sensitivity of the tests (B)</p> Signup and view all the answers

In Chagas' disease, what is a major focus of treatment in advanced stages?

<p>Addressing clinical manifestations (C)</p> Signup and view all the answers

What is the main characteristic of the dilated ventricles in Chagas' disease related to thrombogenesis?

<p>Thrombogenic nature due to their dilatation (B)</p> Signup and view all the answers

Which diagnostic method for Chagas' disease lacks sufficient specificity and sensitivity, requiring two positive tests for confirmation?

<p>Serologic tests for specific IgG antibodies (B)</p> Signup and view all the answers

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