Podcast
Questions and Answers
What is the primary advantage of myoglobin as a cardiac marker?
What is the primary advantage of myoglobin as a cardiac marker?
Its low molecular weight allows it to be released earlier from damaged cells.
Which LDH isoenzyme is primarily found in the heart?
Which LDH isoenzyme is primarily found in the heart?
LDH-1 (H4)
In which tissues are the largest amounts of LDH found?
In which tissues are the largest amounts of LDH found?
Muscles, liver, kidneys, heart, and red blood cells.
What main function does the LDH enzyme serve in the body?
What main function does the LDH enzyme serve in the body?
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Which LDH isoenzyme is predominantly found in the liver and striated muscle?
Which LDH isoenzyme is predominantly found in the liver and striated muscle?
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Explain why myoglobin can be considered an early marker for myocardial infarction (MI).
Explain why myoglobin can be considered an early marker for myocardial infarction (MI).
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Study Notes
Cardiac Biomarkers
Myoglobin
- Small protein that stores oxygen in skeletal and cardiac muscle
- Early marker of Myocardial Infarction (MI) due to its low molecular weight and rapid release from damaged cells
- Allows early detection of acute myocardial infarction
Lactate Dehydrogenase (LDH)
- Enzyme that speeds up chemical reactions in the body to produce energy
- Found in almost all tissues, with highest amounts in muscles, liver, kidneys, heart, and red blood cells
LDH-Isoenzymes
Characteristics
- Five isoenzymes: LDH-1, LDH-2, LDH-3, LDH-4, and LDH-5
- Each isoenzyme has a specific distribution in the body:
- LDH-1 (H4): Heart
- LDH-2 (H3M1): Reticuloendothelial system
- LDH-3 (H2M2): Lungs
- LDH-4 (H1M3): Kidney, placenta, and pancreas
- LDH-5 (M4): Liver and striated (skeletal) muscle
- Normal levels: LDH-2 levels are higher than others
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Description
Learn about cardiac biomarkers, including myoglobin and lactate dehydrogenase (LDH), which are used to detect acute myocardial infarction. Understand the advantages and characteristics of these biomarkers.
