Podcast
Questions and Answers
What is the primary advantage of myoglobin as a cardiac marker?
What is the primary advantage of myoglobin as a cardiac marker?
Its low molecular weight allows it to be released earlier from damaged cells.
Which LDH isoenzyme is primarily found in the heart?
Which LDH isoenzyme is primarily found in the heart?
LDH-1 (H4)
In which tissues are the largest amounts of LDH found?
In which tissues are the largest amounts of LDH found?
Muscles, liver, kidneys, heart, and red blood cells.
What main function does the LDH enzyme serve in the body?
What main function does the LDH enzyme serve in the body?
Which LDH isoenzyme is predominantly found in the liver and striated muscle?
Which LDH isoenzyme is predominantly found in the liver and striated muscle?
Explain why myoglobin can be considered an early marker for myocardial infarction (MI).
Explain why myoglobin can be considered an early marker for myocardial infarction (MI).
Flashcards
Myoglobin advantage as cardiac marker?
Myoglobin advantage as cardiac marker?
Low molecular weight enables early release from damaged cells.
Predominant heart LDH isoenzyme?
Predominant heart LDH isoenzyme?
LDH-1 (H4) is the primary isoenzyme in the heart.
Tissues with abundant LDH?
Tissues with abundant LDH?
Muscles, liver, kidneys, heart, and red blood cells.
Main function of LDH enzyme?
Main function of LDH enzyme?
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LDH isoenzyme in liver/muscle?
LDH isoenzyme in liver/muscle?
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Why is myoglobin an early MI marker?
Why is myoglobin an early MI marker?
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Study Notes
Cardiac Biomarkers
Myoglobin
- Small protein that stores oxygen in skeletal and cardiac muscle
- Early marker of Myocardial Infarction (MI) due to its low molecular weight and rapid release from damaged cells
- Allows early detection of acute myocardial infarction
Lactate Dehydrogenase (LDH)
- Enzyme that speeds up chemical reactions in the body to produce energy
- Found in almost all tissues, with highest amounts in muscles, liver, kidneys, heart, and red blood cells
LDH-Isoenzymes
Characteristics
- Five isoenzymes: LDH-1, LDH-2, LDH-3, LDH-4, and LDH-5
- Each isoenzyme has a specific distribution in the body:
- LDH-1 (H4): Heart
- LDH-2 (H3M1): Reticuloendothelial system
- LDH-3 (H2M2): Lungs
- LDH-4 (H1M3): Kidney, placenta, and pancreas
- LDH-5 (M4): Liver and striated (skeletal) muscle
- Normal levels: LDH-2 levels are higher than others
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