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Questions and Answers
What are the four major groups of carbohydrates based on their structure?
What are the four major groups of carbohydrates based on their structure?
The four major groups of carbohydrates are monosaccharides, disaccharides, oligosaccharides, and polysaccharides.
Explain the difference between a monosaccharide and a disaccharide in terms of hydrolysis.
Explain the difference between a monosaccharide and a disaccharide in terms of hydrolysis.
Monosaccharides are simple sugars that cannot be further hydrolyzed into simpler forms, while disaccharides contain two sugar units that can be broken down into monosaccharides through hydrolysis.
Provide two examples of how carbohydrates are used in the human body.
Provide two examples of how carbohydrates are used in the human body.
Carbohydrates serve as the chief source of energy for the body, and they are also constituents of compound lipids and conjugated proteins.
Explain the role of carbohydrate derivatives in medicine.
Explain the role of carbohydrate derivatives in medicine.
Describe the relationship between carbohydrate metabolism and diabetes mellitus.
Describe the relationship between carbohydrate metabolism and diabetes mellitus.
What is the general formula for monosaccharides?
What is the general formula for monosaccharides?
How does the general formula of carbohydrates relate to their name?
How does the general formula of carbohydrates relate to their name?
Give an example of a disease caused by a deficiency in carbohydrate metabolism.
Give an example of a disease caused by a deficiency in carbohydrate metabolism.
What are the primary functions of glucose in erythrocytes and brain cells?
What are the primary functions of glucose in erythrocytes and brain cells?
Explain the role of fructose in the male reproductive system.
Explain the role of fructose in the male reproductive system.
Describe the significance of galactose in the production of milk.
Describe the significance of galactose in the production of milk.
What is the primary difference between α-sugars and β-sugars in terms of their structural orientation?
What is the primary difference between α-sugars and β-sugars in terms of their structural orientation?
What is the name of a ketotetrose, and what is one of its primary functions?
What is the name of a ketotetrose, and what is one of its primary functions?
Explain the concept of optical activity in relation to monosaccharides.
Explain the concept of optical activity in relation to monosaccharides.
What are the two main categories of monosaccharides based on their carbonyl group?
What are the two main categories of monosaccharides based on their carbonyl group?
Describe the chemical reaction responsible for the formation of cyclic monosaccharides.
Describe the chemical reaction responsible for the formation of cyclic monosaccharides.
What is the common name for glucose?
What is the common name for glucose?
What are the two possible ring forms that can be formed in cyclic monosaccharides?
What are the two possible ring forms that can be formed in cyclic monosaccharides?
What are the four main aldopentoses, and how are they similar?
What are the four main aldopentoses, and how are they similar?
Explain how the presence of asymmetric carbon atoms contributes to the diversity of monosaccharides.
Explain how the presence of asymmetric carbon atoms contributes to the diversity of monosaccharides.
What are the two main ketopentoses, and what is one key function of one of them?
What are the two main ketopentoses, and what is one key function of one of them?
What are the three main aldohexoses, and what makes them significant?
What are the three main aldohexoses, and what makes them significant?
What is the difference in structure between aldotrioses and ketotrioses?
What is the difference in structure between aldotrioses and ketotrioses?
What are the key differences in composition between trioses, tetroses, pentoses, and hexoses?
What are the key differences in composition between trioses, tetroses, pentoses, and hexoses?
Explain the concept of optical isomerism in carbohydrates and provide an example of a simple carbohydrate that exhibits this property.
Explain the concept of optical isomerism in carbohydrates and provide an example of a simple carbohydrate that exhibits this property.
Describe the difference between aldose and ketose sugars and provide an example of each.
Describe the difference between aldose and ketose sugars and provide an example of each.
What are epimers? Provide two examples of epimers, specifying which carbon atom differs between them.
What are epimers? Provide two examples of epimers, specifying which carbon atom differs between them.
Explain the process of anomer formation in carbohydrates and provide two examples of anomers.
Explain the process of anomer formation in carbohydrates and provide two examples of anomers.
What are deoxy sugars? Briefly describe their formation and give one example of a deoxy sugar found in a biological molecule, mentioning the molecule.
What are deoxy sugars? Briefly describe their formation and give one example of a deoxy sugar found in a biological molecule, mentioning the molecule.
Explain how the direction of rotation of plane polarized light is used to classify carbohydrates as dextrorotatory or levorotatory. Provide examples of each type.
Explain how the direction of rotation of plane polarized light is used to classify carbohydrates as dextrorotatory or levorotatory. Provide examples of each type.
Describe the relationship between the number of asymmetric carbon atoms in a carbohydrate molecule and the number of possible optical isomers.
Describe the relationship between the number of asymmetric carbon atoms in a carbohydrate molecule and the number of possible optical isomers.
Briefly explain the role of asymmetric carbon atoms in determining the optical activity of carbohydrates. Provide a specific example.
Briefly explain the role of asymmetric carbon atoms in determining the optical activity of carbohydrates. Provide a specific example.
Name two amino sugars that are essential components of glycosaminoglycans, and specify the glycosaminoglycan each is found in.
Name two amino sugars that are essential components of glycosaminoglycans, and specify the glycosaminoglycan each is found in.
What specific type of linkage connects the carbohydrate residue to the noncarbohydrate residue in a glycoside?
What specific type of linkage connects the carbohydrate residue to the noncarbohydrate residue in a glycoside?
Explain the relationship between neuraminic acid and sialic acids.
Explain the relationship between neuraminic acid and sialic acids.
Describe the structure of muramic acid, highlighting its key components.
Describe the structure of muramic acid, highlighting its key components.
What is the significance of amino sugars in the context of antibiotic activity, providing an example?
What is the significance of amino sugars in the context of antibiotic activity, providing an example?
What is meant by ‘invert sugar’ and how is it formed?
What is meant by ‘invert sugar’ and how is it formed?
Explain the clinical application of sucrose in relation to edema.
Explain the clinical application of sucrose in relation to edema.
What is the reason why sucrose cannot be utilized when administered parenterally?
What is the reason why sucrose cannot be utilized when administered parenterally?
What is the primary function of glycogen in animals, and where is it primarily stored?
What is the primary function of glycogen in animals, and where is it primarily stored?
Explain the key difference between amylose and amylopectin in terms of their molecular structures.
Explain the key difference between amylose and amylopectin in terms of their molecular structures.
What is postmortem glycogenolysis, and why does it eventually cease?
What is postmortem glycogenolysis, and why does it eventually cease?
Describe the process of glycogenolysis. What is its role in maintaining blood glucose levels?
Describe the process of glycogenolysis. What is its role in maintaining blood glucose levels?
What are dextrins, and how are they produced?
What are dextrins, and how are they produced?
Explain the relationship between the deficiency of a specific enzyme and the occurrence of diarrhea.
Explain the relationship between the deficiency of a specific enzyme and the occurrence of diarrhea.
Explain the role of amylase in the digestion of starch.
Explain the role of amylase in the digestion of starch.
What is the relationship between starch and its dietary sources? Provide three examples of foods rich in starch.
What is the relationship between starch and its dietary sources? Provide three examples of foods rich in starch.
Flashcards
Definition of Carbohydrates
Definition of Carbohydrates
Carbohydrates are aldehyde or ketone derivatives of polyhydric alcohols, or yield these on hydrolysis.
Biomedical Importance of Carbohydrates
Biomedical Importance of Carbohydrates
They serve as energy sources, constituents of lipids and proteins, and certain derivatives are used as drugs.
Role in Disease
Role in Disease
Metabolic dysfunctions like galactosemia and diabetes relate to carbohydrate metabolism.
Types of Carbohydrates
Types of Carbohydrates
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Monosaccharides
Monosaccharides
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Disaccharides
Disaccharides
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Oligosaccharides
Oligosaccharides
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Polysaccharides
Polysaccharides
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Dextrorotatory
Dextrorotatory
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Levorotatory
Levorotatory
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Dextrose
Dextrose
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Levulose
Levulose
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Enantiomers
Enantiomers
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Anomers
Anomers
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Aldose-Ketose Isomerism
Aldose-Ketose Isomerism
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Epimers
Epimers
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Fructose
Fructose
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Galactose
Galactose
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Mannose
Mannose
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Cyclic form of sugars
Cyclic form of sugars
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α and β sugars
α and β sugars
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Asymmetric carbon atom
Asymmetric carbon atom
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Optical activity
Optical activity
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Amino Sugars
Amino Sugars
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Glucosamine
Glucosamine
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Galactosamine
Galactosamine
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Mannosamine
Mannosamine
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Muramic Acid
Muramic Acid
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Glycosides
Glycosides
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Invert Sugar
Invert Sugar
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Function of Sucrose
Function of Sucrose
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Trioses
Trioses
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Aldotrioses
Aldotrioses
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Ketotrioses
Ketotrioses
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Tetroses
Tetroses
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Pentoses
Pentoses
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Aldopentoses
Aldopentoses
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Hexoses
Hexoses
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Hydrolysis of disaccharides
Hydrolysis of disaccharides
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Homopolysaccharides
Homopolysaccharides
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Starch
Starch
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Amylose
Amylose
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Glycogen
Glycogen
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Glycogenesis
Glycogenesis
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Dextrins
Dextrins
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Study Notes
Carbohydrate Chemistry
- Carbohydrates are defined chemically as aldehyde or ketone derivatives of higher polyhydric alcohols, or compounds that produce these derivatives upon hydrolysis.
Biomedical Importance of Carbohydrates
- Chief source of energy
- Constituents of combined lipids and conjugated proteins
- Degradation products act as catalysts
- Some carbohydrate derivatives serve as drugs (e.g., cardiac glycosides/antibiotics)
- Lactose is the primary sugar in milk produced by lactating mammary glands
- Degradation products are used to synthesize other substances like fatty acids, cholesterol, and amino acids.
- Carbohydrates are part of mucopolysaccharides, which form the fundamental substance of mesenchymal tissues.
- Inherited deficiencies in carbohydrate metabolic pathways can lead to diseases like galactosemia, glycogen storage diseases (GSDs), and lactose intolerance.
- Disruptions in glucose metabolism cause diabetes mellitus.
Carbohydrates of Physiologic Significance: Classification
- Carbohydrates are classified into four major groups:
- Monosaccharides
- Disaccharides
- Oligosaccharides
- Polysaccharides
Carbohydrates of Physiologic Significance: Monosaccharides
- Monosaccharides are simple sugars that cannot be further hydrolyzed.
- Subtypes are based on carbon atom number (trioses, tetroses, pentoses, hexoses, etc.) and presence of functional groups (aldoses or ketoses).
- Examples include glucose, fructose, galactose, mannose
- Ribose, arabinose, and xylose are important pentoses present in nucleic acids, ATP, GTP, and coenzymes (NAD, FAD)
- Some pentoses can be present in fruits like cherries and grapes
- Also, Ribose & other pentoses can cause alimentary pentosuria, if consumed in high amounts.
- Mannose is part of various glycoproteins
- Galactose is synthesized in the mammary gland to create lactose (milk sugar) and is present in agar, glycosaminoglycans, and glycolipids
- Galactose can be converted to glucose
- Glucose (grape sugar/dextrose) is the primary metabolic fuel for mammals and the fetus.
- All tissues use glucose for energy; erythrocytes and brain cells exclusively use glucose
- Glucose, in the liver and other tissues, is converted to glycogen and galactose
- Fructose is found in fruits, honey, and semen and can be converted to glucose in the liver.
- Seminal fluid is rich in fructose, which is used by sperm for energy.
Carbohydrates of Physiologic Significance: Monosaccharides - Cyclic Structures
- Aldehyde, ketone groups in monosaccharides react with hydroxyl groups to form cyclic structures called pyranose and furanose rings.
- Alpha (α) and beta (β) anomers differ in the position of the hydroxyl group on the anomeric carbon.
- Anomeric carbons are the carbons resulting from the carbonyl group's reaction.
Carbohydrates of Physiologic Significance: Monosaccharides- Optical Activity and Isomerism
- Asymmetric carbon atoms have four different groups attached and exhibit optical activity (rotating plane-polarized light).
- Optical isomers (enantiomers) are mirror images.
- Glucose is dextrorotatory (d or +)
- Fructose is levorotatory (l or −)
- Aldose-ketose isomerism means compounds have the same molecular formula but different functional groups (aldehyde vs. ketone).
2. Disaccharides
- Disaccharides are two monosaccharides linked by a glycosidic bond.
- Sucrose, lactose, maltose, trehalose, and isomaltose are examples of disaccharides (two mono saccharide units bonded).
- Some disaccharides are reducing agents, while others are not.
- Invert sugar is a mixture of fructose and glucose formed by the hydrolysis of sucrose
3. Polysaccharides
- Polysaccharides are complex polymers of monosaccharides.
- Homopolymers contain only one type of monosaccharide (e.g., starch, glycogen, cellulose, agar).
- Heteropolymers contain different types of monomers (e.g., mucopolysaccharides).
- Starch is a storage carbohydrate in plants consisting of amylose (linear) and amylopectin (branched) polymers.
- Glycogen is a storage form of glucose in animals, similar to amylopectin (highly branched)
- Dextrins are hydrolysis products of starch. Different types of dextrins are soluble or insoluble in water, are used as mucilages or in infant feeding.
- Cellulose is a structural component in plants, composed of linked glucose units in a β configuration.
- Inulin is found in Jerusalem artichokes whose units are linked by beta-1,2 bonds.
Carbohydrate Derivatives of Biomedical Importance
- Deoxy sugars are formed by replacing a hydroxyl group with a hydrogen atom. (e.g., deoxyribose).
- Amino sugars contain amino groups. (e.g., glucosamine, galactosamine).
- Neuraminic acid is unstable and only exists in acylated form as sialic acids. Muramic acid is important for cellular walls of bacteria.
- Glycosides contain a carbohydrate and a noncarbohydrate component (aglycone) linked by an acetal bond. Cardiac glycosides are examples.
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