Carbachol Pharmacological Properties Quiz

Carbachol Pharmacological Activity

• Carbachol has similar pharmacological activity to acetylcholine (ACh) as it is an ester of choline, possessing muscarinic and nicotinic properties.
• It interacts with the same receptor sites as AChE, but is hydrolyzed more slowly than acetyl ester, reducing the amount of free enzyme and prolonging ACh duration in the synapse.
• Bethanechol Chloride is 240 times more potent than acetylcholine and is orally effective, with low toxicity and no serious side effects.
• Bethanechol is a potent muscarinic agonist, administered orally and by subcutaneous injection.
• It is more stable to hydrolysis than acetylcholine and methacholine, leading to more ACh being available in the synaptic cleft.
• Carbachol is used for relief of post-surgical urinary retention and abdominal distention.
• The synthesis of Carbachol involves the conversion of choline carbamate to Bethanechol Chloride.
• Carbachol's slower hydrolysis rate reduces the amount of free enzyme, prolonging the duration of ACh in the synapse.
• Carbachol's stability to hydrolysis makes it effective in maintaining ACh levels in the synaptic cleft.
• Bethanechol possesses both muscarinic and nicotinic properties, stimulating cholinergic receptors.
• Carbachol has low toxicity, making it safe for use in clinical settings.
• It is effective in maintaining ACh levels and is used for specific medical conditions such as post-surgical urinary retention and abdominal distention.