Carbachol Pharmacological Properties Quiz

Study Notes

Carbachol Pharmacological Activity

Carbachol has similar pharmacological activity to acetylcholine (ACh) as it is an ester of choline, possessing muscarinic and nicotinic properties.
It interacts with the same receptor sites as AChE, but is hydrolyzed more slowly than acetyl ester, reducing the amount of free enzyme and prolonging ACh duration in the synapse.
Bethanechol Chloride is 240 times more potent than acetylcholine and is orally effective, with low toxicity and no serious side effects.
Bethanechol is a potent muscarinic agonist, administered orally and by subcutaneous injection.
It is more stable to hydrolysis than acetylcholine and methacholine, leading to more ACh being available in the synaptic cleft.
Carbachol is used for relief of post-surgical urinary retention and abdominal distention.
The synthesis of Carbachol involves the conversion of choline carbamate to Bethanechol Chloride.
Carbachol's slower hydrolysis rate reduces the amount of free enzyme, prolonging the duration of ACh in the synapse.
Carbachol's stability to hydrolysis makes it effective in maintaining ACh levels in the synaptic cleft.
Bethanechol possesses both muscarinic and nicotinic properties, stimulating cholinergic receptors.
Carbachol has low toxicity, making it safe for use in clinical settings.
It is effective in maintaining ACh levels and is used for specific medical conditions such as post-surgical urinary retention and abdominal distention.

Description

Pharmacological Properties of Carbachol Quiz: Test your knowledge of the pharmacological activity of carbachol, its similarities to ACh, receptor stimulation, and hydrolysis rate. Learn about its muscarinic and nicotinic properties and its interaction with AChE. Perfect for pharmacology students and professionals.