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Questions and Answers
What are hard gelatin capsules made of?
What is the advantage of hard gelatin capsules?
What is a disadvantage of hard gelatin capsules?
What permits a wide prescribing opportunity by the physician in relation to hard gelatin capsules?
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What do hard gelatin capsules allow for in terms of dispensing powders?
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What are hard gelatin capsules essentially according to the text?
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What is the primary purpose of adding titanium dioxide to the gelatin mixture?
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Which type of gelatin is mainly manufactured from animal bones?
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What contributes to the firmness of gelatin capsules?
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What is the primary method for manufacturing hard gelatin capsule shells?
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What happens to gelatin capsules in high humidity conditions?
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What is the primary purpose of plasticizers in soft gelatin capsules?
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In which type of capsule does gelatin rapidly release its contents in gastric fluid?
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What do HPMC capsules generally have lower Equilibrium Moisture Content (EMC) than?
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What distinguishes Type A from Type B gelatin?
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What happens to hard gelatin capsules in extreme dryness?
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Study Notes
Composition of Hard Gelatin Capsules
- Hard gelatin capsules are made of gelatin, water, and sometimes other additives such as titanium dioxide, plasticizers, and colorants.
Advantages of Hard Gelatin Capsules
- Hard gelatin capsules allow for flexible prescribing opportunities by physicians due to their availability in various sizes and colors.
Disadvantages of Hard Gelatin Capsules
- A disadvantage of hard gelatin capsules is that they can become brittle and crack in extreme dryness.
Dispensing Powders
- Hard gelatin capsules allow for the dispensing of powders in precise and uniform amounts.
Definition of Hard Gelatin Capsules
- Hard gelatin capsules are essentially a container made of a mixture of gelatin and other additives, molded into a specific shape.
Titanium Dioxide
- The primary purpose of adding titanium dioxide to the gelatin mixture is to provide opacity and whiteness to the capsules.
Type of Gelatin
- Bone gelatin, which is mainly manufactured from animal bones, is often used in the production of hard gelatin capsules.
Firmness of Gelatin Capsules
- The firmness of gelatin capsules is contributed by the water content, which is controlled to achieve the desired level of firmness.
Manufacturing of Hard Gelatin Capsules
- The primary method for manufacturing hard gelatin capsule shells involves dipping metal pins into a gelatin solution and then drying the shells.
Effect of Humidity
- In high humidity conditions, gelatin capsules can absorb moisture and become soft and weak.
Plasticizers in Soft Gelatin Capsules
- The primary purpose of plasticizers in soft gelatin capsules is to enhance their flexibility and prevent them from becoming brittle.
Rapid Release of Contents
- In hard gelatin capsules, gelatin rapidly releases its contents in gastric fluid.
Equilibrium Moisture Content (EMC)
- HPMC (Hydroxypropylmethylcellulose) capsules generally have lower Equilibrium Moisture Content (EMC) than gelatin capsules.
Type A vs. Type B Gelatin
- Type A gelatin is derived from acid-treated raw materials, whereas Type B gelatin is derived from alkaline-treated raw materials.
Effect of Dryness
- In extreme dryness, hard gelatin capsules can become brittle and crack.
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Description
Test your knowledge about capsules, which are solid dosage forms made of gelatin and used to enclose medicinal substances. Learn about the advantages and features of hard gelatin capsules.
