Capsule Technology

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Questions and Answers

What is the primary purpose of capsules?

  • To provide a modified release of medicinal substances
  • To increase the shelf life of medicinal substances
  • To increase the bioavailability of medicinal substances
  • To mask the taste of medicinal substances (correct)

What is a characteristic of hard capsules?

  • They are more expensive than soft capsules
  • They are used for modified release of medicinal substances
  • They are cylindrical in shape (correct)
  • They are composed of one piece

What is an advantage of hard capsules?

  • They are easier to formulate than tablets (correct)
  • They are cheaper to produce than tablets
  • They are more suitable for materials with high moisture content
  • They have a slower production rate than tablets

What is a disadvantage of hard capsules?

<p>They are more expensive than tablets (D)</p> Signup and view all the answers

What is a potential advantage of hard capsules over tablets?

<p>They have a higher bioavailability (D)</p> Signup and view all the answers

What is a characteristic of soft capsules?

<p>They are one-piece capsules (A)</p> Signup and view all the answers

Why are some hard capsules unsuitable?

<p>They are unsuitable for materials with high moisture content (A)</p> Signup and view all the answers

What is a potential use of hard capsules?

<p>To separate incompatible materials (C)</p> Signup and view all the answers

What are the two types of capsules?

<p>Hard and soft capsules</p> Signup and view all the answers

What is the main advantage of capsular formulations over tablets in terms of bioavailability?

<p>Potentially higher bioavailability</p> Signup and view all the answers

What is a unique feature of capsules that allows for the separation of incompatible materials?

<p>Capsules inside capsules</p> Signup and view all the answers

What is a limitation of using hard capsules for certain materials?

<p>High level of 'free' moisture or hygroscopicity</p> Signup and view all the answers

What is an advantage of hard capsules in terms of processing and filling?

<p>Easier to formulate and lower stress in processing and filling</p> Signup and view all the answers

What is the shape of most hard capsules?

<p>Cylindrical</p> Signup and view all the answers

What is a potential application of hard capsules?

<p>Modified release, materials which cannot be compressed, solid or semi-solid contents</p> Signup and view all the answers

What is a drawback of using hard capsules compared to tablets?

<p>Higher cost and slower production rate</p> Signup and view all the answers

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Study Notes

Capsule Technology

Definition and Overview

  • Capsules are solid preparations with hard or soft shells of various shapes and capacities, containing a single dose of active substances.
  • One capsule can contain one or more active ingredients.

History

  • Capsules were invented in the 19th century to mask the taste of medicinal substances.

Types of Capsules

  • There are two types of capsules: hard and soft.
  • Most hard and soft capsules are orally delivered.

Hard Capsules

Composition and Structure

  • Cylindrical shaped, consisting of two pieces: a shorter cap and a longer body.
  • The cap goes over the body to contain the contents.

Advantages

  • Convenient to carry and have an elegant appearance.
  • Reasonably stable and tasteless, making them easy to swallow.
  • Easier to formulate than tablets, with lower stress in processing and filling.
  • Capsule shell is soluble in physiological fluids at body temperature.
  • Potential for higher bioavailability than tablets due to non-compression of powders.
  • Readily identifiable, with the possibility of using two colors.
  • Can be used to separate incompatible materials and for modified release, and for solid or semi-solid contents.

Disadvantages

  • Expensive, with a higher cost than tablets.
  • Slower production rate than tablets, with an output rate of around 20% of that of tablets.
  • Unsuitable for materials containing high levels of 'free' moisture or that are hygroscopic.

Soft Capsules

  • Also known as soft gelatin capsules, soft gels, or one-piece capsules.

Capsule Technology

Definition and Overview

  • Capsules are solid preparations with hard or soft shells of various shapes and capacities, containing a single dose of active substances.
  • One capsule can contain one or more active ingredients.

History

  • Capsules were invented in the 19th century to mask the taste of medicinal substances.

Types of Capsules

  • There are two types of capsules: hard and soft.
  • Most hard and soft capsules are orally delivered.

Hard Capsules

Composition and Structure

  • Cylindrical shaped, consisting of two pieces: a shorter cap and a longer body.
  • The cap goes over the body to contain the contents.

Advantages

  • Convenient to carry and have an elegant appearance.
  • Reasonably stable and tasteless, making them easy to swallow.
  • Easier to formulate than tablets, with lower stress in processing and filling.
  • Capsule shell is soluble in physiological fluids at body temperature.
  • Potential for higher bioavailability than tablets due to non-compression of powders.
  • Readily identifiable, with the possibility of using two colors.
  • Can be used to separate incompatible materials and for modified release, and for solid or semi-solid contents.

Disadvantages

  • Expensive, with a higher cost than tablets.
  • Slower production rate than tablets, with an output rate of around 20% of that of tablets.
  • Unsuitable for materials containing high levels of 'free' moisture or that are hygroscopic.

Soft Capsules

  • Also known as soft gelatin capsules, soft gels, or one-piece capsules.

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