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Questions and Answers
What is the primary purpose of capsules?
What is a characteristic of hard capsules?
What is an advantage of hard capsules?
What is a disadvantage of hard capsules?
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What is a potential advantage of hard capsules over tablets?
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What is a characteristic of soft capsules?
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Why are some hard capsules unsuitable?
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What is a potential use of hard capsules?
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What are the two types of capsules?
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What is the main advantage of capsular formulations over tablets in terms of bioavailability?
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What is a unique feature of capsules that allows for the separation of incompatible materials?
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What is a limitation of using hard capsules for certain materials?
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What is an advantage of hard capsules in terms of processing and filling?
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What is the shape of most hard capsules?
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What is a potential application of hard capsules?
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What is a drawback of using hard capsules compared to tablets?
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Study Notes
Capsule Technology
Definition and Overview
- Capsules are solid preparations with hard or soft shells of various shapes and capacities, containing a single dose of active substances.
- One capsule can contain one or more active ingredients.
History
- Capsules were invented in the 19th century to mask the taste of medicinal substances.
Types of Capsules
- There are two types of capsules: hard and soft.
- Most hard and soft capsules are orally delivered.
Hard Capsules
Composition and Structure
- Cylindrical shaped, consisting of two pieces: a shorter cap and a longer body.
- The cap goes over the body to contain the contents.
Advantages
- Convenient to carry and have an elegant appearance.
- Reasonably stable and tasteless, making them easy to swallow.
- Easier to formulate than tablets, with lower stress in processing and filling.
- Capsule shell is soluble in physiological fluids at body temperature.
- Potential for higher bioavailability than tablets due to non-compression of powders.
- Readily identifiable, with the possibility of using two colors.
- Can be used to separate incompatible materials and for modified release, and for solid or semi-solid contents.
Disadvantages
- Expensive, with a higher cost than tablets.
- Slower production rate than tablets, with an output rate of around 20% of that of tablets.
- Unsuitable for materials containing high levels of 'free' moisture or that are hygroscopic.
Soft Capsules
- Also known as soft gelatin capsules, soft gels, or one-piece capsules.
Capsule Technology
Definition and Overview
- Capsules are solid preparations with hard or soft shells of various shapes and capacities, containing a single dose of active substances.
- One capsule can contain one or more active ingredients.
History
- Capsules were invented in the 19th century to mask the taste of medicinal substances.
Types of Capsules
- There are two types of capsules: hard and soft.
- Most hard and soft capsules are orally delivered.
Hard Capsules
Composition and Structure
- Cylindrical shaped, consisting of two pieces: a shorter cap and a longer body.
- The cap goes over the body to contain the contents.
Advantages
- Convenient to carry and have an elegant appearance.
- Reasonably stable and tasteless, making them easy to swallow.
- Easier to formulate than tablets, with lower stress in processing and filling.
- Capsule shell is soluble in physiological fluids at body temperature.
- Potential for higher bioavailability than tablets due to non-compression of powders.
- Readily identifiable, with the possibility of using two colors.
- Can be used to separate incompatible materials and for modified release, and for solid or semi-solid contents.
Disadvantages
- Expensive, with a higher cost than tablets.
- Slower production rate than tablets, with an output rate of around 20% of that of tablets.
- Unsuitable for materials containing high levels of 'free' moisture or that are hygroscopic.
Soft Capsules
- Also known as soft gelatin capsules, soft gels, or one-piece capsules.
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Description
Understand the basics of capsules, including their definition, composition, and manufacturing process. Learn about the advantages and disadvantages of hard and soft capsules.
