Cannabinoids and Their Effects

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Questions and Answers

What is the primary medical use of Cannabidiol?

  • To treat loss of appetite in people with AIDS (correct)
  • To increase appetite in healthy individuals
  • To induce sleep in insomnia patients
  • To alleviate headaches and migraines

Which method of consumption does not produce smoke or odor?

  • Vaporization (correct)
  • Oral (capsules)
  • Topical application
  • Smoking

Which of the following is NOT affected by THC?

  • Sensory perception
  • Pleasure centers of the brain
  • Digestion speed (correct)
  • Coordinated movement

How can Cannabidiol be administered?

<p>Through various methods including oils and edibles (B)</p> Signup and view all the answers

What sensation is produced when THC overstimulates certain parts of the brain?

<p>Euphoria or 'high' (B)</p> Signup and view all the answers

Which cannabinoid receptor is primarily found throughout the neuronal system?

<p>CB1 (B)</p> Signup and view all the answers

What effect might result from lasting impairment after marijuana use?

<p>Difficulty learning new skills (D)</p> Signup and view all the answers

What is a primary role of CBD at CB1 receptors?

<p>Preventing THC from binding (D)</p> Signup and view all the answers

What does the term 'cannabis' primarily refer to?

<p>The plant Cannabis sativa L (D)</p> Signup and view all the answers

Synthetic cannabinoids, such as Spice or K2, are known for which of the following characteristics?

<p>Chemical similarity to cannabis compounds (C)</p> Signup and view all the answers

Which cannabinoid is the major psychoactive ingredient in cannabis?

<p>Delta-9 tetrahydrocannabinol (THC) (A)</p> Signup and view all the answers

Which receptors in the basal ganglia and cerebellum are linked to sedation and movement effects?

<p>CB1 (C)</p> Signup and view all the answers

What is the THC content range typically found in hashish?

<p>20-60% (D)</p> Signup and view all the answers

What cognitive effects are associated with problems in the processing of information due to marijuana use?

<p>Poor concentration (D)</p> Signup and view all the answers

What might be a life-threatening health effect associated with the use of synthetic cannabinoids?

<p>Severe respiratory distress (D)</p> Signup and view all the answers

Which of the following is NOT a synonym for marijuana?

<p>Kief (C)</p> Signup and view all the answers

Which area of the brain is particularly involved with perceptual and cognitive effects due to the presence of CB1 receptors?

<p>Hippocampus (A)</p> Signup and view all the answers

Which part of the cannabis plant is primarily processed to create hashish?

<p>Buds (B)</p> Signup and view all the answers

How does the psychoactive effect of cannabis influence a person?

<p>It alters mood, thoughts, and perceptions (A)</p> Signup and view all the answers

What characteristic differentiates marijuana from hashish?

<p>Hashish is a product made from cannabis resin (D)</p> Signup and view all the answers

Which of the following terms describes the hair-like structures on cannabis buds?

<p>Trichomes (D)</p> Signup and view all the answers

What is the main difference between THC and CBD?

<p>THC is intoxicating, while CBD is non-intoxicating. (A)</p> Signup and view all the answers

What is Delta-8 THC associated with?

<p>It can lead to medical emergencies in high doses. (B)</p> Signup and view all the answers

Which of the following products is Marinol® categorized as?

<p>A prescription medication with active CBD. (B)</p> Signup and view all the answers

What type of plants are primarily used for their textile fibers and edible oils?

<p>Hemp plants containing very small amounts of delta-9 THC. (A)</p> Signup and view all the answers

What are common side effects of CBD?

<p>Drowsiness and diarrhea. (A)</p> Signup and view all the answers

Which compound found in cannabis is mainly responsible for intoxication?

<p>Delta-9 THC. (D)</p> Signup and view all the answers

Which of the following statements about CBD is inaccurate?

<p>CBD can lead to intoxication similar to THC. (C)</p> Signup and view all the answers

What is a potential risk of consuming high amounts of Delta-8 THC products?

<p>Breathing problems and medical emergencies. (D)</p> Signup and view all the answers

What is a common short-term effect of cannabis use?

<p>Increased appetite (C)</p> Signup and view all the answers

Which of the following is NOT a reported short-term effect of cannabis?

<p>Large airway inflammation (B)</p> Signup and view all the answers

What can be a psychological side effect of consuming a large amount of cannabis?

<p>Hallucinations (B)</p> Signup and view all the answers

Which of the following effects is typically associated with high levels of THC in cannabis?

<p>Elevated heart rate (B)</p> Signup and view all the answers

What is a potential long-term health risk related to cannabis smoking?

<p>Respiratory issues (C)</p> Signup and view all the answers

Which health risk relates to cardiovascular effects of long-term cannabis use?

<p>Increased risk of arrhythmias (C)</p> Signup and view all the answers

Which short-term effect may be experienced due to cannabis consumption?

<p>Dry mouth (B)</p> Signup and view all the answers

What is one possible mental effect of cannabis intoxication?

<p>Impaired time perception (A)</p> Signup and view all the answers

What condition is characterized by nausea, vomiting, and abdominal pain after long-term cannabis use?

<p>Cannabinoid hyperemesis syndrome (D)</p> Signup and view all the answers

Which of the following gastrointestinal issues is NOT mentioned as a potential effect of cannabis use?

<p>Celiac disease (C)</p> Signup and view all the answers

What substance is hashish primarily made from?

<p>THC-rich resin (D)</p> Signup and view all the answers

Where is hashish primarily sourced from?

<p>Middle East and North Africa (B)</p> Signup and view all the answers

What is a significant health risk associated with long-term cannabis use?

<p>Increased cancer risk (B)</p> Signup and view all the answers

Which drug is considered stronger than marijuana due to its concentrated form?

<p>Hashish (A)</p> Signup and view all the answers

What is the main difference between hashish and hashish oil?

<p>Hashish is a solid form while hashish oil is a liquid extract (A)</p> Signup and view all the answers

What is the equivalent effect of a drop of hashish oil compared to marijuana?

<p>Equal to a single marijuana joint (B)</p> Signup and view all the answers

Flashcards

What is Cannabis?

Cannabis refers to the dried leaves, flowers, stems, and seeds of the Cannabis sativa L plant. It contains various cannabinoids, including THC (tetrahydrocannabinol), the psychoactive compound.

What is Weed or Marijuana?

A type of cannabis product made from the dried buds and leaves of the cannabis plant. It contains a moderate amount of THC.

What is Hashish?

Hashish, often shortened to 'hash', is a concentrated form of cannabis made from the resin of the buds of the cannabis plant. It's compacted into a sticky brown substance with a higher concentration of THC compared to marijuana.

What is THC?

THC (tetrahydrocannabinol) is the primary psychoactive compound found in cannabis plants. It's responsible for the intoxicating effects.

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What are Trichomes?

Trichomes are microscopic hair-like structures found on cannabis plants. They contain the resin (sticky substance) which is used to make hashish.

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What is Hemp?

Hemp refers to the Cannabis sativa L plant used for industrial purposes, such as producing fiber and oil. It's a low-THC variety.

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What are the Effects of Cannabis?

Cannabis can temporarily alter a person's mood, thoughts, and perceptions. These effects are due to the presence of THC.

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How Does Hashish Compare to Marijuana in Potency?

Hashish is typically stronger than marijuana due to its higher THC concentration. This makes it more potent and can produce more intense effects.

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THC (Tetrahydrocannabinol)

A chemical compound found in cannabis, known for its psychoactive effects. It's the main component responsible for 'getting high'.

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CBD (Cannabidiol)

Another compound found in cannabis, but unlike THC, it doesn't produce a 'high'. It's often marketed for various benefits, like relaxation and pain relief.

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Delta-8 THC

A specific form of THC that's also psychoactive but is different from the common Delta-9 THC. It's gaining popularity for its potential therapeutic benefits.

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Marinol®

A prescription medication containing CBD, available in pill form. It's used to treat specific medical conditions.

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Cannabis sativa L plant

The plant species that produces both THC and CBD. It's commonly known as marijuana or cannabis.

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Hemp

A type of Cannabis sativa L plant with very low levels of THC. It's primarily used for its fibers and seeds.

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Cannabis

A general term for the cannabis plant and its various preparations, including marijuana, hashish, and weed.

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Cannabinoids

The group of chemicals found in cannabis, each with different properties. THC and CBD are two examples.

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What is Cannabidiol (CBD)?

Cannabidiol, or CBD, is a compound found in cannabis plants. It's known for its potential medicinal benefits without causing a 'high'. It's often used to treat various conditions like loss of appetite, chronic pain, and anxiety.

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What is Marinol?

Marinol is a prescription drug containing THC, the psychoactive compound in cannabis. It's used to treat specific medical conditions like loss of appetite and nausea caused by chemotherapy.

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What is a Vaporizer, specifically the 'G-Pen'?

Vaporizers are devices that heat cannabis, releasing vapor instead of smoke. This method offers a smoother and potentially safer experience, but some vaporizer designs mimic electronic cigarettes and are popular among teens. These devices are often disguised as pens, making them covert and less detectable.

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How does THC affect the brain?

THC interacts with cannabinoid receptors in the brain, impacting areas responsible for pleasure, memory, thinking, and perception. This interaction leads to the 'high' experienced when using cannabis, as these brain functions are overstimulated.

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How can Cannabis be consumed?

Cannabis can be consumed in various ways, including smoking, vaporizing, and oral ingestion through oils, capsules, edibles, tinctures, and lozenges. Topical applications and suppositories also exist for different purposes.

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What are some effects of being high?

The effects of being high can involve memory problems, difficulty processing information, altered perception of time and senses, and impaired concentration and coordination.

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What are some long-term effects of marijuana use?

Even after the immediate effects of marijuana wear off, some people may experience lasting impairment, making it difficult to perform complex tasks, learn new skills, maintain alertness and focus, recall information, and make sound decisions.

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Where are CB1 and CB2 receptors located?

CB1 receptors are found throughout the nervous system, while CB2 receptors are primarily found in the immune system.

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How does THC interact with CB1 receptors?

THC is an agonist of CB1 receptors, which means it binds to and activates them. This activation can lead to the psychoactive effects of marijuana.

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How do CB1 receptors affect different parts of the brain?

Activation of CB1 receptors in the hippocampus and cortex may be responsible for the perceptual and cognitive effects of marijuana, such as altered perception and memory problems. Activation of CB1 receptors in the basal ganglia and cerebellum may contribute to sedation and movement difficulties. Activation of CB1 receptors in the spinal cord and brainstem may contribute to the analgesic (pain-relieving) effects of marijuana.

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How does CBD interact with CB1 receptors?

CBD acts as a negative allosteric modulator at CB1 receptors. This means it prevents THC (and other agonists) from binding to and activating these receptors.

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What are synthetic cannabinoids?

Synthetic cannabinoids are lab-made substances chemically similar to compounds found in cannabis. They can have higher concentrations of THC than natural cannabis and can produce more potent and dangerous effects.

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What are the risks associated with synthetic cannabinoids?

Use of synthetic cannabinoids is associated with serious adverse effects, including potential life-threatening complications.

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What are some short-term effects of cannabis use?

Short-term effects of cannabis use can include feelings of euphoria, relaxation, altered time perception, impaired thinking and memory, and physical side effects like increased appetite and red eyes.

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What are some long-term health risks associated with cannabis use?

Long-term cannabis use can lead to respiratory problems like chronic bronchitis, and potentially increased risk of stroke, heart attack, and heart rhythm issues.

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How does cannabis affect cognitive function?

Cannabis can cause memory loss, impaired motor coordination, and altered perception, making it difficult to perform tasks requiring concentration and coordination.

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How does cannabis smoking affect the lungs?

Long-term cannabis smoking is associated with lung issues like inflammation, increased resistance to airflow, and chronic bronchitis.

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How does cannabis use impact the heart?

Cannabis use can increase heart rate, potentially leading to an increased risk of cardiovascular problems such as stroke and heart attack.

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How can cannabis affect mental state?

Cannabis can create feelings of paranoia, anxiety, and fear, especially when used in large amounts or by those with little experience.

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How does cannabis use affect appetite and weight?

While cannabis can increase appetite, long-term use may lead to weight gain and associated health issues.

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What are some of the physical symptoms of cannabis use?

Cannabis can cause dry mouth, red eyes, and a sense of altered perception, affecting senses like sight, sound, and touch.

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What is Cannabinoid Hyperemesis Syndrome (CHS)?

A serious condition caused by long-term, heavy cannabis use, characterized by nausea, vomiting, and abdominal pain.

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What is Hashish Oil?

An extract produced by dissolving the cannabinoids from cannabis using a solvent.

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What are Schedule I Drugs?

A category of drugs with a high potential for abuse and no currently accepted medical use in the United States.

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What is THC (tetrahydrocannabinol)?

The psychoactive component of cannabis, responsible for the 'high' effect.

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What is Pancreatitis?

A condition marked by inflammation of the pancreas, often associated with excessive alcohol consumption or heavy cannabis use.

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What is Peptic Ulcer Disease?

A disorder characterized by sores in the lining of the stomach or duodenum, commonly caused by bacteria.

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What is Acid Reflux?

A condition where stomach acid flows back up into the esophagus, causing heartburn and discomfort.

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Study Notes

Marijuana (Cannabis) Overview

  • Marijuana (also called cannabis) refers to dried leaves, flowers, stems, and seeds of the Cannabis sativa L plant. This plant contains at least 125 different cannabinoids, including delta-9 tetrahydrocannabinol (THC), the main psychoactive component.
  • THC has intoxicating effects, temporarily altering mood, thoughts, and perceptions.
  • Hashish is a resin extracted from the leaves, protecting them from the sun's drying rays.

Types of Cannabis Products

  • Cannabis, weed, marijuana, and hemp are often used interchangeably, although the Opium Act differentiates.
  • Weed/marijuana is made from dried buds and leaves of the cannabis plant, typically containing 25-30% THC.
  • Hashish (often shortened to hash) is produced from the resin of the cannabis plant buds and is compressed into a sticky brown substance, with a THC concentration of 20-60%. It is typically stronger than marijuana.

Marijuana Basics - Common Forms

  • Images are available showing different forms of marijuana, including dried buds and a compressed, darker substance.

Trichomes and Hashish

  • Trichomes are hair-like structures on the cannabis plant (visually exemplified).
  • These trichomes are compressed/processed to form hashish.

Other Names for Marijuana

  • A variety of common names for marijuana were presented in a bulleted list. This list included slang terms and informal names.

Marijuana Chemical Components

  • Marijuana contains approximately 100 cannabinoids plus other chemicals in varying concentrations.
  • Specific cannabinoids like THC, delta-9-tetrahydrocannabinol; delta-9-tetrahydrocannabivarin, delta-8 tetrahydrocannabinol; cannabigerol; cannabinol; cannabichromene and cannabidiol (CBD) were highlighted.
  • Chemical structures (images) are accompanying these cannabinoids.

CBD

  • CBD is a non-intoxicating cannabinoid often marketed for various uses.
  • CBD is found in Cannabis sativa L but usually in very small concentrations without the intoxicating effects of THC.
  • Hemp plants generally contain low amounts of delta-9 THC.

Delta-8 THC

  • Delta-8 THC is a psychoactive cannabinoid derived from the cannabis plant
  • Delta-8 THC products are not FDA approved for safe use. Overconsumption may lead to serious health problems up to and including acute medical emergencies.

Marinol®

  • Marinol® is a Schedule III controlled substance containing the cannabinoid CBD, taken as a pill.
  • It is prescribed for medical purposes, including treating appetite loss associated with AIDS and to reduce nausea and vomiting caused by cancer chemotherapy.

How Marijuana is Taken

  • Marijuana can be taken in various ways, including smoking, vaporization, oral ingestion (e.g., oils, capsules, edibles, tinctures, lozenges), topical applications, and suppositories.
  • Vaping devices are a popular new method for consuming marijuana, often marketed as "G-Pens." These pens emit no smoke or odor.

Marijuana, the Brain, and Impairment

  • THC affects cannabinoid receptors in the brain, influencing pleasure, memory, thinking, and movement. Over-stimulation of these receptors causes the "high" effect.
  • The effects of being "high" include memory problems, difficulty processing information, decreased sensory perception and coordination issues, and poor concentration.
  • Lasting impairments can include difficulty with complex tasks, learning new skills, maintaining alertness and attention, and recalling information.

THC Mechanism Of Action (MOA)

  • There are two known cannabinoid receptors: CB1 and CB2.
  • CB1 receptors are throughout the central nervous system, and CB2 receptors are in the immune system.
  • THC acts as an agonist of the CB1 receptor.
  • Different areas of the brain and spinal cord may be influenced by these receptors. These effects include perceptual and cognitive effects, sedation, motor movement, and analgesia.

CBD Mechanism Of Action (MOA)

  • CBD acts as a negative allosteric modulator of CB1 receptors, preventing THC from binding to them.

Synthetic Cannabinoids

  • Synthetic cannabinoids chemically resemble naturally occurring cannabis compounds, but they may possess a significantly higher concentration of psychoactive substances.
  • They are also known as Spice and K2.
  • Use of synthetic cannabinoids can cause severe, potentially life-threatening health problems.

Short-Term Effects of Marijuana

  • Intoxication, causing feelings of happiness, relaxation, impaired thinking, and memory.
  • Anxiety, fear, distrust, panic, and hallucinations, heightened by larger amounts or infrequent use.
  • Physical side effects, including increased appetite, nausea, vomiting, elevated heart rate, respiratory problems, and more.
  • Short-term effects may include specific symptoms such as red eyes, dry mouth, altered perception, impaired motor coordination, paranoia, and delayed reaction time.

Long-Term Health Risks of Marijuana

  • Lung health issues (e.g., airway inflammation and chronic bronchitis).
  • Cardiovascular issues (e.g., increased risk of stroke, heart attack, and arrhythmias).
  • Gastrointestinal issues (e.g., cannabinoid hyperemesis syndrome, nausea, vomiting, abdominal pain, acid reflux, pancreatitis, peptic ulcer disease).
  • Increased risk of certain cancers (e.g., head, neck, and throat).

Other Drugs with Similar Effects

  • Hashish and hashish oil are made from THC-rich cannabis resin, are similar to marijuana, but often considered stronger. These substances are extracted and processed in various forms (balls, cakes, sheets) and often smoked from pipes or mixed with tobacco in cigarettes.
  • Hashish is commonly produced in the Middle East, North Africa, Pakistan, and Afghanistan.

Hashish Oil

  • Hashish oil is pure cannabis resin extracted from the cannabis plant, using a solvent-based extraction process.
  • The color and odor of the extract vary based on the solvent used for extraction.
  • A drop or two of hashish oil on a cigarette is roughly comparable to a marijuana joint.

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