Candida Glabrata Azole Resistance Quiz

What mechanism is responsible for conferring resistance against azole compounds in C. albicans?

Which mechanism involves the prevention of accumulating toxic metabolites by inactivating another enzyme in the pathway?

What mechanism involves the alteration of membrane homeostasis to make it more rigid or more fluid?

Which mechanism involves the acquisition of mutations in genes encoding antifungal targets, resulting in resistance in many pathogenic fungi?

Which mechanism involves the ability of fungal pathogens to excrete antifungal compounds through overexpression of specific efflux pumps?

Is the alteration of membrane homeostasis a mechanism of antifungal resistance?

Does the overexpression of efflux pumps contribute to antifungal resistance in many fungal species?

Is the prevention of accumulating toxic metabolites by inactivating another enzyme a mechanism of antifungal resistance?

Do non-synonymous SNPs lead to amino-acid alterations and reduced binding affinity of the antifungal to the target?

Is the activation of stress pathways not essential for surviving stressful conditions in the environment?

Is the loss of mitochondrial function associated with increased fluconazole resistance in glabrata isolate?

Is rebalancing of the hypoxic response suggested as a mechanism for increased fluconazole resistance due to loss of mitochondrial function?

Do azoles and polynx amphotericin B have an impact on membrane homeostasis by disturbing cellular ergosterol content?

Does the adjustment of membrane homeostasis involve changing the ratio of phospholipid species to make the membrane more rigid or more fluid?

Is Hsp90 chaperone a key regulator in stress signaling and involved in protein folding and stabilizing many proteins involved in signal transduction protein?

What is the impact of azoles and polynx amphotericin B on membrane homeostasis?

What is the suggested mechanism for increased fluconazole resistance due to loss of mitochondrial function?

What is the role of Hsp90 chaperone in stress signaling?

How do eukaryotic cells adjust membrane homeostasis in response to antifungal drugs?

What is the effect of loss of mitochondrial function on fluconazole resistance in glabrata isolate?