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Cancer Progression Processes Quiz

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Questions and Answers

Which process accelerates the development of cervical cancer and colon cancer?

Independence from the environment (metastasizing)

Increased proliferation (correct)

Decreased cell death (apoptosis)

Consecutive cycles of mutations/selections

What is a key requirement for tumor cells in the process of metastasis?

Dependence on the environment

Vascular growth (angiogenesis) (correct)

Reduced proliferation

Decreased genetic instability

Which external factors are considered as cancer risk factors?

Mutagens like smoke and asbestos

Radiation-induced DNA damage from UV light

Human Papillomavirus (HPV)

All of the above (correct)

What is the purpose of the Ames test in relation to cancer research?

Identify environmental mutagens Signup and view all the answers

How do consecutive cycles of mutations/selections impact cancer development?

Promote the accumulation of genetic changes Signup and view all the answers

What role does decreased cell death (apoptosis) play in the progression of cancer?

Promotes tumor growth Signup and view all the answers

Which process plays an important role in embryogenesis, removal of old epithelial cells, and activated immune cells?

Decreased cell death (apoptosis) Signup and view all the answers

What is the main consequence of polyp formation in the gut?

Increased proliferation in the intestinal epithelium Signup and view all the answers

Which factor contributes to the acceleration of the process in cervical cancer and colon cancer development?

Increased proliferation Signup and view all the answers

What leads to disruption of homeostasis in abnormal cells?

Increased cell division Signup and view all the answers

Which characteristic is a common feature in the accelerated development of cervical and colon cancers?

Increased genetic instability Signup and view all the answers

What factor is responsible for decreased apoptosis in abnormal cells?

Spontaneous mutations Signup and view all the answers

What is the role of HPV infection in the development of cervical cancer?

Inhibition of tumor suppressor genes Signup and view all the answers

Which gene mutation is responsible for the initiation of the adenoma-carcinoma sequence in colon cancer?

Inactivation of APC Signup and view all the answers

What is the consequence of inactivating p53 mutations in cancers?

Apoptosis activation Signup and view all the answers

In the context of cancer development, what is the function of the transcription factor P53?

Promotion of growth arrest Signup and view all the answers

How do oncogenic human papilloma viruses (HPV) contribute to cervical cancer development?

Inhibiting p53 and RB Signup and view all the answers

What is the significance of loss of APC in the Wnt signaling pathway in colon cancer?

Accumulation of beta-catenin Signup and view all the answers