Cancer Progression Processes Quiz

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Questions and Answers

Which process accelerates the development of cervical cancer and colon cancer?

  • Independence from the environment (metastasizing)
  • Increased proliferation (correct)
  • Decreased cell death (apoptosis)
  • Consecutive cycles of mutations/selections

What is a key requirement for tumor cells in the process of metastasis?

  • Dependence on the environment
  • Vascular growth (angiogenesis) (correct)
  • Reduced proliferation
  • Decreased genetic instability

Which external factors are considered as cancer risk factors?

  • Mutagens like smoke and asbestos
  • Radiation-induced DNA damage from UV light
  • Human Papillomavirus (HPV)
  • All of the above (correct)

What is the purpose of the Ames test in relation to cancer research?

<p>Identify environmental mutagens (B)</p> Signup and view all the answers

How do consecutive cycles of mutations/selections impact cancer development?

<p>Promote the accumulation of genetic changes (C)</p> Signup and view all the answers

What role does decreased cell death (apoptosis) play in the progression of cancer?

<p>Promotes tumor growth (B)</p> Signup and view all the answers

Which process plays an important role in embryogenesis, removal of old epithelial cells, and activated immune cells?

<p>Decreased cell death (apoptosis) (B)</p> Signup and view all the answers

What is the main consequence of polyp formation in the gut?

<p>Increased proliferation in the intestinal epithelium (C)</p> Signup and view all the answers

Which factor contributes to the acceleration of the process in cervical cancer and colon cancer development?

<p>Increased proliferation (B)</p> Signup and view all the answers

What leads to disruption of homeostasis in abnormal cells?

<p>Increased cell division (A)</p> Signup and view all the answers

Which characteristic is a common feature in the accelerated development of cervical and colon cancers?

<p>Increased genetic instability (D)</p> Signup and view all the answers

What factor is responsible for decreased apoptosis in abnormal cells?

<p>Spontaneous mutations (A)</p> Signup and view all the answers

What is the role of HPV infection in the development of cervical cancer?

<p>Inhibition of tumor suppressor genes (B)</p> Signup and view all the answers

Which gene mutation is responsible for the initiation of the adenoma-carcinoma sequence in colon cancer?

<p>Inactivation of APC (C)</p> Signup and view all the answers

What is the consequence of inactivating p53 mutations in cancers?

<p>Apoptosis activation (D)</p> Signup and view all the answers

In the context of cancer development, what is the function of the transcription factor P53?

<p>Promotion of growth arrest (C)</p> Signup and view all the answers

How do oncogenic human papilloma viruses (HPV) contribute to cervical cancer development?

<p>Inhibiting p53 and RB (C)</p> Signup and view all the answers

What is the significance of loss of APC in the Wnt signaling pathway in colon cancer?

<p>Accumulation of beta-catenin (B)</p> Signup and view all the answers

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