Podcast
Questions and Answers
Which enzyme isoform can be used to determine clonality?
Which enzyme isoform can be used to determine clonality?
What is the normal kappa to lambda light chain ratio in B cells?
What is the normal kappa to lambda light chain ratio in B cells?
What distinguishes neoplasia from hyperplasia and repair?
What distinguishes neoplasia from hyperplasia and repair?
Which of the following is true about p53?
Which of the following is true about p53?
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What is the consequence of p53 inducing apoptosis?
What is the consequence of p53 inducing apoptosis?
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What is the result of Rb mutation?
What is the result of Rb mutation?
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What is the function of Bcl2 in follicular lymphoma?
What is the function of Bcl2 in follicular lymphoma?
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What is the goal of cancer screening?
What is the goal of cancer screening?
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What are the categories of oncogenes involved in cancer?
What are the categories of oncogenes involved in cancer?
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What is the role of carcinogens in cancer development?
What is the role of carcinogens in cancer development?
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Study Notes
Cancer Overview and Carcinogenesis
- Tumor nomenclature is based on lineage of differentiation and whether the tumor is benign or malignant.
- Cancer is the 2nd leading cause of death in both adults and children.
- The most common cancers by incidence in adults are breast/prostate, lung, and colorectal.
- The leading causes of cancer mortality in adults are lung, breast/prostate, and colorectal.
- Cancer begins as a single mutated cell and approximately 30 divisions occur before the earliest clinical symptoms arise.
- The goal of screening is to catch dysplasia before it becomes carcinoma or carcinoma before clinical symptoms arise.
- Carcinogens are agents that damage DNA, increasing the risk for cancer.
- DNA mutations eventually disrupt key regulatory systems, allowing for tumor promotion and progression.
- Proto-oncogenes are essential for cell growth and differentiation; mutations of proto-oncogenes form oncogenes that lead to unregulated cellular growth.
- Categories of oncogenes include growth factors, growth factor receptors, signal transducers, nuclear regulators, and cell cycle regulators.
- Common carcinogenic agents include chemicals, oncogenic viruses, and radiation.
- Specific examples of carcinogenic agents and associated cancers are provided.
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Description
Test your knowledge of cancer overview and carcinogenesis with this informative quiz. Explore tumor nomenclature, common cancers, carcinogenic agents, and more.
