Podcast
Questions and Answers
What type of mutations are responsible for progressing the growth of cancer?
What type of mutations are responsible for progressing the growth of cancer?
- Beneficial mutations
- Phenotypic mutations
- Driver mutations (correct)
- Passenger mutations
What creates genetic diversity within cancer cells?
What creates genetic diversity within cancer cells?
- Clonal evolution (correct)
- Phenotypic variations
- Driver mutations
- Differentiation process
According to the cancer stem cell model, which subset of cells has tumorigenic potential?
According to the cancer stem cell model, which subset of cells has tumorigenic potential?
- Cancer stem cells
- Cells in the dominant population
- Subset of cells (correct)
- All cells
In the context of cancer development, what is the key function of Cancer Stem Cells (CSCs)?
In the context of cancer development, what is the key function of Cancer Stem Cells (CSCs)?
What is the term for mutational events that do not benefit the cancer's growth?
What is the term for mutational events that do not benefit the cancer's growth?
What type of evolution leads to all cells in the dominant population(s) having tumorigenic potential?
What type of evolution leads to all cells in the dominant population(s) having tumorigenic potential?
What is the therapeutic mechanism of inhibiting self-renewal in acute myeloid leukemia?
What is the therapeutic mechanism of inhibiting self-renewal in acute myeloid leukemia?
Which pathway is targeted to inhibit self-renewal in tumors using Gamma-secretase inhibitors?
Which pathway is targeted to inhibit self-renewal in tumors using Gamma-secretase inhibitors?
In the context of genetic heterogeneity, what plays a significant role in immunotherapy against tumors?
In the context of genetic heterogeneity, what plays a significant role in immunotherapy against tumors?
How can drug resistance be reversed in tumors according to the text?
How can drug resistance be reversed in tumors according to the text?
Which factor is involved in niche targeting to inhibit self-renewal in tumors?
Which factor is involved in niche targeting to inhibit self-renewal in tumors?
What is the role of MUC1 on colorectal cancer stem cells according to the provided text?
What is the role of MUC1 on colorectal cancer stem cells according to the provided text?
What is one method mentioned in the text to target cancer stem cells residing next to vasculature?
What is one method mentioned in the text to target cancer stem cells residing next to vasculature?
In the context of cancer vaccines, which type of vaccine is Provenge specifically considered to be?
In the context of cancer vaccines, which type of vaccine is Provenge specifically considered to be?
Which characteristic is associated with Pancreatic CSCs according to the text?
Which characteristic is associated with Pancreatic CSCs according to the text?
What is the role of MT110, the bispecific antibody discussed in the text?
What is the role of MT110, the bispecific antibody discussed in the text?
What represents a method discussed in the text to improve the destruction of residual CSCs after debulking?
What represents a method discussed in the text to improve the destruction of residual CSCs after debulking?
In the context of cancer research mentioned in the text, what does H-TPDC stand for?
In the context of cancer research mentioned in the text, what does H-TPDC stand for?
What is a major limitation of the gold standard transplantation assay for identifying cancer stem cells?
What is a major limitation of the gold standard transplantation assay for identifying cancer stem cells?
What is the term used to describe the event where a huge amount of tumor mutations develops at early tumourigenesis?
What is the term used to describe the event where a huge amount of tumor mutations develops at early tumourigenesis?
What is a characteristic of the cancer stem cell hierarchy in acute myeloid leukemia?
What is a characteristic of the cancer stem cell hierarchy in acute myeloid leukemia?
What is a consequence of genetic heterogeneity in tumors?
What is a consequence of genetic heterogeneity in tumors?
What is a possible outcome of phenotypic heterogeneity in tumors?
What is a possible outcome of phenotypic heterogeneity in tumors?
What is a limitation of the transplantation assay in identifying cancer stem cells?
What is a limitation of the transplantation assay in identifying cancer stem cells?
What is the primary reason for the variability in cancer survival rates?
What is the primary reason for the variability in cancer survival rates?
Which of the following is a major problem in cancer treatment?
Which of the following is a major problem in cancer treatment?
What contributes to the heterogeneity of cancer cells?
What contributes to the heterogeneity of cancer cells?
What is a consequence of cancer heterogeneity?
What is a consequence of cancer heterogeneity?
What is the relationship between genetic and phenotypic heterogeneity?
What is the relationship between genetic and phenotypic heterogeneity?
What can be seen as a collection of rare genetic diseases?
What can be seen as a collection of rare genetic diseases?
