Cancer Genetics: Mutation Frequencies

Which type of gene has the highest mutation frequency among tumor suppressor genes in the most common cancers?

In which cancer type is the mutation frequency of phosphatases the lowest?

Among the transcription factors listed, which one has the highest mutation frequency in lung cancer?

Which gene shows the highest mutation frequency in breast cancer?

Which of the following gene types has the lowest overall mutation frequency across the provided cancers?

What is the mutation frequency of the KRAS gene in colorectal cancer?

Which gene has a higher mutation frequency in the liver than in the prostate?

What is the mutation frequency of the gene RB1 in cervical cancer?

Table 1: Frequency of Mutations in Driver Genes

Oncogenes: 89.4% mutated frequency
Tumor suppressor genes: 90.5% mutated frequency
Kinases: 61.8% mutated frequency
Phosphatases: 19.3% mutated frequency
Transcription factors: 72.2% mutated frequency

Table 2: Frequency of Altered Genes in Common Cancers

Oncogenes:
- Lung: 98.3%
- Breast: 92.9%
- Colorectal: 98.2%
- Prostate: 86.3%
- Stomach: 96.7%
- Liver: 92.6%
- Thyroid: 93.3%
- Cervix: 97.9%
- Bladder: 94.2%
Tumor suppressor genes:
- Lung: 98.85%
- Breast: 95.1%
- Colorectal: 99.3%
- Prostate: 93.7%
- Stomach: 99.5%
- Liver: 97.3%
- Cervix: 95.2%
- Bladder: 94.2%
Kinases:
- Lung: 87.3%
- Breast: 68.4%
- Colorectal: 79.4%
- Prostate: 55.6%
- Stomach: 75.2%
- Liver: 73.3%
- Thyroid: 71.9%
- Cervix: 79.2%
- Bladder: 79.2%
Phosphatases:
- Lung: 35.45%
- Breast: 11.5%
- Colorectal: 31.5%
- Prostate: 31.8%
- Stomach: 41.1%
- Liver: 16.6%
- Thyroid: 3.5%
- Cervix: 11.6%
- Bladder: 19.9%
Transcription factors:
- Lung: 92.3%
- Breast: 79.2%
- Colorectal: 94.6%
- Prostate: 72.3%
- Stomach: 92.6%
- Liver: 81.4%
- Thyroid: 21.4%
- Cervix: 76.7%
- Bladder: 86.9%

Table 3: Frequency of Mutations in Certain Genes in Different Cancer Types

This table shows the frequency of mutations in specific genes (CDK4, CDK6, TP53, KRAS, RB1) across different cancer types (Lung, Breast, Colorectal, etc.)
Data is presented as a percentage for each gene-cancer type combination.

Explore the frequencies of mutations in driver genes and their involvement in common cancers. This quiz covers oncogenes, tumor suppressor genes, kinases, and phosphatases across various types of cancer. Test your understanding of these critical genetic factors in cancer biology.