Podcast
Questions and Answers
Which type of gene has the highest mutation frequency among tumor suppressor genes in the most common cancers?
Which type of gene has the highest mutation frequency among tumor suppressor genes in the most common cancers?
- KRAS
- CDK4
- TP53 (correct)
- RB1
In which cancer type is the mutation frequency of phosphatases the lowest?
In which cancer type is the mutation frequency of phosphatases the lowest?
- Cervical cancer (correct)
- Thyroid cancer
- Bladder cancer
- Liver cancer
Among the transcription factors listed, which one has the highest mutation frequency in lung cancer?
Among the transcription factors listed, which one has the highest mutation frequency in lung cancer?
- NF-kB (correct)
- TP53
- CDK4
- c-Myc
Which gene shows the highest mutation frequency in breast cancer?
Which gene shows the highest mutation frequency in breast cancer?
Which of the following gene types has the lowest overall mutation frequency across the provided cancers?
Which of the following gene types has the lowest overall mutation frequency across the provided cancers?
What is the mutation frequency of the KRAS gene in colorectal cancer?
What is the mutation frequency of the KRAS gene in colorectal cancer?
Which gene has a higher mutation frequency in the liver than in the prostate?
Which gene has a higher mutation frequency in the liver than in the prostate?
What is the mutation frequency of the gene RB1 in cervical cancer?
What is the mutation frequency of the gene RB1 in cervical cancer?
Flashcards
Frequency of driver gene mutations in cancer
Frequency of driver gene mutations in cancer
The frequency of mutations in different driver genes across various cancer types. It shows the prevalence of mutations in oncogenes, tumor suppressor genes, kinases, phosphatases, and transcription factors.
Gene alteration analysis in cancer
Gene alteration analysis in cancer
The analysis of gene alterations, specifically mutations in oncogenes, tumor suppressor genes, kinases, phosphatases, and transcription factors, in different cancer types.
Mutation frequency in specific cancer genes
Mutation frequency in specific cancer genes
The frequency of mutations in specific driver genes like CDK4, CDK6, TP53, KRAS, and RB1 in different cancer types.
What is an oncogene?
What is an oncogene?
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What is a tumor suppressor gene?
What is a tumor suppressor gene?
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What is a kinase?
What is a kinase?
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What is a phosphatase?
What is a phosphatase?
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What is a transcription factor?
What is a transcription factor?
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Study Notes
Table 1: Frequency of Mutations in Driver Genes
- Oncogenes: 89.4% mutated frequency
- Tumor suppressor genes: 90.5% mutated frequency
- Kinases: 61.8% mutated frequency
- Phosphatases: 19.3% mutated frequency
- Transcription factors: 72.2% mutated frequency
Table 2: Frequency of Altered Genes in Common Cancers
-
Oncogenes:
- Lung: 98.3%
- Breast: 92.9%
- Colorectal: 98.2%
- Prostate: 86.3%
- Stomach: 96.7%
- Liver: 92.6%
- Thyroid: 93.3%
- Cervix: 97.9%
- Bladder: 94.2%
-
Tumor suppressor genes:
- Lung: 98.85%
- Breast: 95.1%
- Colorectal: 99.3%
- Prostate: 93.7%
- Stomach: 99.5%
- Liver: 97.3%
- Cervix: 95.2%
- Bladder: 94.2%
-
Kinases:
- Lung: 87.3%
- Breast: 68.4%
- Colorectal: 79.4%
- Prostate: 55.6%
- Stomach: 75.2%
- Liver: 73.3%
- Thyroid: 71.9%
- Cervix: 79.2%
- Bladder: 79.2%
-
Phosphatases:
- Lung: 35.45%
- Breast: 11.5%
- Colorectal: 31.5%
- Prostate: 31.8%
- Stomach: 41.1%
- Liver: 16.6%
- Thyroid: 3.5%
- Cervix: 11.6%
- Bladder: 19.9%
-
Transcription factors:
- Lung: 92.3%
- Breast: 79.2%
- Colorectal: 94.6%
- Prostate: 72.3%
- Stomach: 92.6%
- Liver: 81.4%
- Thyroid: 21.4%
- Cervix: 76.7%
- Bladder: 86.9%
Table 3: Frequency of Mutations in Certain Genes in Different Cancer Types
- This table shows the frequency of mutations in specific genes (CDK4, CDK6, TP53, KRAS, RB1) across different cancer types (Lung, Breast, Colorectal, etc.)
- Data is presented as a percentage for each gene-cancer type combination.
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