Cancer Characteristics and Growth Factors
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Questions and Answers

What happens when two normal cells come into contact?

  • Cell death occurs
  • Cell division stops (correct)
  • Cell division accelerates
  • Cell growth becomes unregulated
  • How is a malignant cell characterized?

  • Uncontrolled multiplication (correct)
  • Crossing the basement membrane
  • Organized manner of growth
  • Division stops upon contact
  • What distinguishes a benign tumor from a malignant one?

  • Uncontrolled multiplication
  • Metastasizes to other organs
  • One layer of cells
  • Does not cross the basement membrane (correct)
  • What happens when growth factors are dysregulated?

    <p>Cancer formation</p> Signup and view all the answers

    Why is the dysregulation of growth factors significant in cancer development?

    <p>It leads to uncontrolled cell growth</p> Signup and view all the answers

    What is a common characteristic of cytotoxic compounds mentioned in the text?

    <p>They are usually DNA intercalators</p> Signup and view all the answers

    How are cytotoxic compounds usually synthesized according to the text?

    <p>From natural products</p> Signup and view all the answers

    Which type of compounds are commonly used as DNA intercalators?

    <p>Cytotoxic compounds</p> Signup and view all the answers

    What is the primary source of the synthesis of cytotoxic compounds?

    <p>Natural products</p> Signup and view all the answers

    Which characteristic distinguishes cytotoxic compounds from other types of compounds?

    <p>Being DNA intercalators</p> Signup and view all the answers

    What is the main mechanism of action (MOA) of Bleomycin?

    <p>Inhibition of DNA synthesis</p> Signup and view all the answers

    Which organism is Bleomycin derived from?

    <p>Streptomyces verticillatus</p> Signup and view all the answers

    What is a notable adverse effect associated with Bleomycin?

    <p>Pulmonary fibrosis</p> Signup and view all the answers

    Which of the following processes is NOT inhibited by Bleomycin?

    <p>Cell membrane formation</p> Signup and view all the answers

    What type of breaks can Bleomycin cause in DNA?

    <p>Both single-strand and double-strand breaks</p> Signup and view all the answers

    What is the primary function of the p53 gene?

    <p>Act as a tumor suppressor</p> Signup and view all the answers

    Why is primary chemotherapy not considered curative in most cancer cases?

    <p>Most cancers are discovered in advanced stages</p> Signup and view all the answers

    What happens when the p53 gene is mutated?

    <p>It accelerates neoplastic phenotype</p> Signup and view all the answers

    In the context of cancer treatment, why is it important to detect cancers at an early stage?

    <p>To increase the chance of curative treatment success</p> Signup and view all the answers

    What role does p53 gene play in the cell cycle?

    <p>Removing deviant cells</p> Signup and view all the answers

    What may have high curative potential following surgical resection of the primary tumor?

    <p>Chemotherapy regimens with clinical activity against advanced disease</p> Signup and view all the answers

    What is crucial for chemotherapy regimens to have high curative potential after surgical resection?

    <p>Appropriate dose and schedule</p> Signup and view all the answers

    Which factor plays a significant role in determining the curative potential of chemotherapy regimens?

    <p>Clinical activity against advanced disease</p> Signup and view all the answers

    What could potentially lead to high curative potential in chemotherapy regimens?

    <p>Surgical resection of the primary tumor</p> Signup and view all the answers

    What is emphasized as essential for achieving curative outcomes with chemotherapy after surgery?

    <p>Administering the correct dose and schedule</p> Signup and view all the answers

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