Cancer Characteristics and Growth Factors
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Questions and Answers

What happens when two normal cells come into contact?

  • Cell death occurs
  • Cell division stops (correct)
  • Cell division accelerates
  • Cell growth becomes unregulated

How is a malignant cell characterized?

  • Uncontrolled multiplication (correct)
  • Crossing the basement membrane
  • Organized manner of growth
  • Division stops upon contact

What distinguishes a benign tumor from a malignant one?

  • Uncontrolled multiplication
  • Metastasizes to other organs
  • One layer of cells
  • Does not cross the basement membrane (correct)

What happens when growth factors are dysregulated?

<p>Cancer formation (D)</p> Signup and view all the answers

Why is the dysregulation of growth factors significant in cancer development?

<p>It leads to uncontrolled cell growth (C)</p> Signup and view all the answers

What is a common characteristic of cytotoxic compounds mentioned in the text?

<p>They are usually DNA intercalators (A)</p> Signup and view all the answers

How are cytotoxic compounds usually synthesized according to the text?

<p>From natural products (C)</p> Signup and view all the answers

Which type of compounds are commonly used as DNA intercalators?

<p>Cytotoxic compounds (B)</p> Signup and view all the answers

What is the primary source of the synthesis of cytotoxic compounds?

<p>Natural products (D)</p> Signup and view all the answers

Which characteristic distinguishes cytotoxic compounds from other types of compounds?

<p>Being DNA intercalators (D)</p> Signup and view all the answers

What is the main mechanism of action (MOA) of Bleomycin?

<p>Inhibition of DNA synthesis (D)</p> Signup and view all the answers

Which organism is Bleomycin derived from?

<p>Streptomyces verticillatus (C)</p> Signup and view all the answers

What is a notable adverse effect associated with Bleomycin?

<p>Pulmonary fibrosis (D)</p> Signup and view all the answers

Which of the following processes is NOT inhibited by Bleomycin?

<p>Cell membrane formation (D)</p> Signup and view all the answers

What type of breaks can Bleomycin cause in DNA?

<p>Both single-strand and double-strand breaks (B)</p> Signup and view all the answers

What is the primary function of the p53 gene?

<p>Act as a tumor suppressor (A)</p> Signup and view all the answers

Why is primary chemotherapy not considered curative in most cancer cases?

<p>Most cancers are discovered in advanced stages (C)</p> Signup and view all the answers

What happens when the p53 gene is mutated?

<p>It accelerates neoplastic phenotype (C)</p> Signup and view all the answers

In the context of cancer treatment, why is it important to detect cancers at an early stage?

<p>To increase the chance of curative treatment success (B)</p> Signup and view all the answers

What role does p53 gene play in the cell cycle?

<p>Removing deviant cells (B)</p> Signup and view all the answers

What may have high curative potential following surgical resection of the primary tumor?

<p>Chemotherapy regimens with clinical activity against advanced disease (C)</p> Signup and view all the answers

What is crucial for chemotherapy regimens to have high curative potential after surgical resection?

<p>Appropriate dose and schedule (C)</p> Signup and view all the answers

Which factor plays a significant role in determining the curative potential of chemotherapy regimens?

<p>Clinical activity against advanced disease (C)</p> Signup and view all the answers

What could potentially lead to high curative potential in chemotherapy regimens?

<p>Surgical resection of the primary tumor (D)</p> Signup and view all the answers

What is emphasized as essential for achieving curative outcomes with chemotherapy after surgery?

<p>Administering the correct dose and schedule (C)</p> Signup and view all the answers

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