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Cancer Cell Specific Drug Targeting Quiz

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Questions and Answers

What is the function of mesna in decreasing the incidence of kidney and bladder toxicity from Cyclophosphamide?

Stimulate aldehyde dehydrogenase
React with electrophilic species (correct)
Inactivate glutathione
Increase DNA repair mechanisms

What is the harmless metabolite that results from the reaction of mesna with electrophilic species?

Sulfonate concentrate
Water (correct)
Chlorine
Sodium

Which enzymes are involved in the increased inactivation of Cyclophosphamide by resistance mechanisms?

Glutathione and oxidase enzymes
DNA polymerase enzymes
Cytochrome P450 enzymes
Aldehyde dehydrogenase and alcohol dehydrogenase (correct)

Which cancer types can be treated with Cyclophosphamide?

Breast cancer, non-Hodgkin’s lymphoma, chronic lymphocytic leukemia (C) Signup and view all the answers

What is a mechanism of resistance to Cyclophosphamide similar to other alkylating agents?

Decreased uptake and activation (D) Signup and view all the answers

How does mesna help prevent hemorrhagic cystitis caused by Cyclophosphamide?

Reacting with harmful electrophilic species (A) Signup and view all the answers

What is the mechanism of action of Cyclophosphamide in treating cancers?

Alkylating agent causing DNA damage (D) Signup and view all the answers

Which of the following is NOT a type of cancer treated by Cyclophosphamide?

Prostate cancer (A) Signup and view all the answers

What are the common mechanisms of resistance to Cyclophosphamide?

Decreased uptake and activation (D) Signup and view all the answers

What enzyme is involved in the increased inactivation of Cyclophosphamide in resistant cancers?

Aldehyde dehydrogenase (A) Signup and view all the answers

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