Cancer Cell Specific Drug Targeting Quiz
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Questions and Answers

What is the function of mesna in decreasing the incidence of kidney and bladder toxicity from Cyclophosphamide?

  • Stimulate aldehyde dehydrogenase
  • React with electrophilic species (correct)
  • Inactivate glutathione
  • Increase DNA repair mechanisms
  • What is the harmless metabolite that results from the reaction of mesna with electrophilic species?

  • Sulfonate concentrate
  • Water (correct)
  • Chlorine
  • Sodium
  • Which enzymes are involved in the increased inactivation of Cyclophosphamide by resistance mechanisms?

  • Glutathione and oxidase enzymes
  • DNA polymerase enzymes
  • Cytochrome P450 enzymes
  • Aldehyde dehydrogenase and alcohol dehydrogenase (correct)
  • Which cancer types can be treated with Cyclophosphamide?

    <p>Breast cancer, non-Hodgkin’s lymphoma, chronic lymphocytic leukemia</p> Signup and view all the answers

    What is a mechanism of resistance to Cyclophosphamide similar to other alkylating agents?

    <p>Decreased uptake and activation</p> Signup and view all the answers

    How does mesna help prevent hemorrhagic cystitis caused by Cyclophosphamide?

    <p>Reacting with harmful electrophilic species</p> Signup and view all the answers

    What is the mechanism of action of Cyclophosphamide in treating cancers?

    <p>Alkylating agent causing DNA damage</p> Signup and view all the answers

    Which of the following is NOT a type of cancer treated by Cyclophosphamide?

    <p>Prostate cancer</p> Signup and view all the answers

    What are the common mechanisms of resistance to Cyclophosphamide?

    <p>Decreased uptake and activation</p> Signup and view all the answers

    What enzyme is involved in the increased inactivation of Cyclophosphamide in resistant cancers?

    <p>Aldehyde dehydrogenase</p> Signup and view all the answers

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