Podcast
Questions and Answers
What does the term 'metastasis' refer to in cancer biology?
What does the term 'metastasis' refer to in cancer biology?
- The initial formation of a tumor
- The presence of cancer in the bloodstream
- The spread of cancer cells to other parts of the body (correct)
- The removal of a tumor surgically
Which of the following correctly describes 'benign' tumors?
Which of the following correctly describes 'benign' tumors?
- They invade surrounding tissues aggressively.
- They have a high potential for metastasis.
- They are non-cancerous and do not spread. (correct)
- They are always fatal to the host.
Which gene categories are commonly mutated in oncogenesis?
Which gene categories are commonly mutated in oncogenesis?
- Only proto-oncogenes
- Oncogenes, tumor-suppressors, and genome maintenance genes (correct)
- Only genome maintenance genes
- Only tumor-suppressor genes
What is the ‘multi-hit’ model in relation to cancer?
What is the ‘multi-hit’ model in relation to cancer?
How do direct-acting carcinogens differ from indirect-acting carcinogens?
How do direct-acting carcinogens differ from indirect-acting carcinogens?
Which statement accurately describes the role of oncometabolites?
Which statement accurately describes the role of oncometabolites?
What is the primary distinction between carcinomas and sarcomas?
What is the primary distinction between carcinomas and sarcomas?
Which hallmark of cancer cells is characterized by their ability to evade apoptosis?
Which hallmark of cancer cells is characterized by their ability to evade apoptosis?
Flashcards
Aneuploidy
Aneuploidy
Having an abnormal number of chromosomes.
Oncometabolite
Oncometabolite
A metabolite that promotes cancer development.
Benign Tumor
Benign Tumor
A non-cancerous tumor that does not spread.
Malignant Tumor
Malignant Tumor
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Metastasis
Metastasis
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Direct-acting carcinogen
Direct-acting carcinogen
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Indirect-acting carcinogen
Indirect-acting carcinogen
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Multi-hit model
Multi-hit model
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Oncogene
Oncogene
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Proto-oncogene
Proto-oncogene
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Tumor Suppressor
Tumor Suppressor
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Genome Maintenance Genes
Genome Maintenance Genes
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Carcinoma
Carcinoma
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Sarcoma
Sarcoma
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Study Notes
Cancer Learning Objectives
- Define key terms: aneuploid, oncometabolite, benign, malignant, metastasis, indirect/direct-acting carcinogens, "multi-hit" model, oncogenes, protooncogenes, tumor suppressors, genome maintenance genes
- Describe cancer cell biological hallmarks
- Explain how genetics and mutations contribute to cancer predisposition/progression
- Classify malignant tumors (carcinomas or sarcomas)
- Detail the processes of cancer initiation, progression, and metastasis
- Identify gene categories mutated in oncogenesis
- Explain how deregulated cellular/molecular mechanisms contribute to cancer development
Cancer Text Excerpt
- Lodish et al. (2021), Chapter 25
- Verse (Matthew 5:29-30): Losing a body part is better than losing your whole body due to sin (NIV)
- Surgical removal of cancerous parts is sometimes necessary to save the rest of the body—a medical analogy
- Sin affects the entire body, not just specific parts
- Christ's death is a complete sacrifice to eliminate sin (Galatians 2:20)
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Description
Dive into the complex world of cancer biology and genetics with this quiz. Explore key terms, biological hallmarks, and the genetic factors that contribute to cancer development. Understand tumor classification and the processes of initiation, progression, and metastasis, as well as the implications of deregulated mechanisms in oncogenesis.
