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Cancer Biochemistry: Cancer-Related Cachexia

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Cancer Biochemistry: Cancer-Related Cachexia

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Questions and Answers

What is the role of TNF-a in cachexia?

Reducing basal metabolic rate

Promoting skeletal muscle growth

Suppressing appetite (correct)

Stimulating appetite

Which cells produce TNF-a?

Macrophages and some neoplastic cells (correct)

Neutrophils

Fibroblasts

Lymphocytes

What is the effect of TNF-a on basal metabolic rate?

Has no effect on it

Varies depending on the individual

Increases it (correct)

Decreases it

What is the result of ubiquitin-proteasome degradation of skeletal muscle?

Breakdown of skeletal muscle Signup and view all the answers

What is a common symptom of cancer-related cachexia?

Anorexia Signup and view all the answers

What is the primary mechanism by which TNF-a contributes to weight loss in cancer-related cachexia?

Inducing anorexia through hypothalamic influences Signup and view all the answers

Which of the following is a consequence of the hypermetabolic state in cancer-related cachexia?

Elevated basal metabolic rate Signup and view all the answers

What is the primary function of macrophages in relation to TNF-a production?

To respond to infection by producing TNF-a Signup and view all the answers

What is the result of the degradation of actin and myosin in skeletal muscle?

Muscle wasting Signup and view all the answers

Which of the following is a characteristic of neoplastic cells that contributes to cancer-related cachexia?

Their ability to produce TNF-a Signup and view all the answers

Study Notes

Cachexia is a hypermetabolic state driven by TNF-a and IL-6
Characterized by anorexia, malaise, weight loss, and anemia
TNF-a is produced by macrophages in response to infection and by some neoplastic cells
TNF-a influences the hypothalamus, leading to appetite suppression
TNF-a increases basal metabolic rate
Ubiquitin-proteasome degradation of skeletal muscle proteins, including actin and myosin, contributes to muscle wasting in cancer-related cachexia

Cachexia is a hypermetabolic state driven by TNF-a and IL-6
Characterized by anorexia, malaise, weight loss, and anemia
TNF-a is produced by macrophages in response to infection and by some neoplastic cells
TNF-a influences the hypothalamus, leading to appetite suppression
TNF-a increases basal metabolic rate
Ubiquitin-proteasome degradation of skeletal muscle proteins, including actin and myosin, contributes to muscle wasting in cancer-related cachexia

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Description

Explore the biochemistry of cancer-related cachexia, including the role of TNF-a, IL-6, and ubiquitin-proteasome degradation in skeletal muscle loss. Learn about the hypermetabolic state and its effects on the body.